Browse Articles

Recovery of High-Voltage Oxygen Redox Activity by Eliminating Residual Oxygen Dimers

Tracking dynamic EEG connectivity in schizophrenia and bipolar disorder

Abstract Psychotic syndromes, such as schizophrenia (SCZ) and bipolar disorder (BD), significantly disrupt brain electrical activity, with functional connectivity (FC) being particularly affected. However, FC is often estimated as a static measure, overlooking the brain dynamic fluctuations that naturally occur, even at rest. In this study, we investigated alterations in dynamic FC (dFC) using resting-state electroencephalographic (EEG) data from SCZ patients, BD patients, and age-matched healthy control (HC) subjects. To achieve this, the instantaneous amplitude correlation (IAC) was computed for each EEG recording within the canonical frequency bands. We then analyzed the first- to fourth-order cumulants of the average strength (aS) time series derived from the IAC matrices. Statistically significant differences were obtained between the SCZ and HC groups in aS mean (first-order cumulant) and aS skewness (third-order cumulant) at the gamma band, while the BD group reported differences against the HC group in aS mean at the delta band. Additionally, both disorders exhibited altered aS skewness in the beta band; these findings suggest disruptions in interneuronal communication, manifesting as “pathologically Gaussian” aS distributions over time. Our results highlight the potential of dFC analysis to uncover brain function anomalies that remain undetected with conventional approaches.

Allosteric Modulation toward Nonionic Covalent Organic Framework Nanosheets

Investigation the adsorption mechanisms, chemical resistance and mechanical strength of the synthesized chitosan/activated carbon composite in methylene blue removal

Crystallization-Induced Diastereomer Transformations of Donor–Acceptor Cyclopropanes

Alginate formulations with high loads of zebularine and retinoic acid promote tissue growth and innervation and induce extensive epigenetic repatterning

Abstract The study presents the development of a small-molecule epigenetic regenerative therapy that combines a demethylating agent, zebularine, with retinoic acid, acting as a transcriptional activator, and an alginate carrier. Subcutaneously injected formulations based on 2% sodium alginate containing high loads of zebularine (240 mg/ml) and retinoic acid (0.8 mg/ml) promoted regenerative responses in a mouse model of ear pinna punch wound involving the restoration of tissue architecture, the growth of nerve and vessel networks, and extensive alterations in gene methylation and expression profiles with no adverse effects in the animals. Among the remarkable changes in global gene methylation are those in neurodevelopmental genes. In vitro studies showed rapid discharge of zebularine but not retinoic acid from the alginate formulations. Live ultrasound imaging demonstrated gradual absorption of the subcutaneously injected alginate formulations, which may explain the in vivo activity of retinoic acid following subcutaneous administration. Cell culture tests exhibited no significant cytotoxicity of the alginate formulations. The simplicity of composition, preparation, and administration of alginate-based drug formulations is a distinctive advantage. The effective induction of regenerative response, together with a high safety profile of subcutaneously administered pro-regenerative alginate formulations, opens the way to testing further regenerative therapies for hard-to-reach lesions.

Validity of a ramp protocol based on whole-body climbing-specific exercise for peak oxygen uptake in physically active adults

Multivalency Enables Signal Processing at Single Protein Level

Optimised reverse-phase chromatography for clinical detection of vitamins A and E in serum

Proton Reduction with a Cobalt-Doped Thiomolybdate Cluster: A Structural and Functional Model of Co-Doped MoS ₂

RETRACTED ARTICLE: Reinforcement learning-driven deep learning approaches for optimized robot trajectory planning

Total Synthesis of Annotinolide B via Sequential Quinoline Dearomatization

Top causes of visual impairment, satisfaction with eye care services, and associated factors among visually impaired patients attending an eye care center in Ethiopia

In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy

Computational investigation of CO2 hydrogenation and electrochemical reduction to formic acid and methanol using chalcogen-doped nitrogen-graphene nanoflake as a metal-free catalyst

Daily briefing: How the plastics-treaty breakdown could pave the way for something better

Precise Dual-Metal Pairs Enable Ultrafast Structural Response for CO ₂ -to-Ethylene Photoconversion

Dictyostelium exhibits PCB-induced impairment of proliferation, development and stress response, emerging as model for conserved environmental toxicity

Targeting of SKP2 to combat drug resistance in multiple myeloma

Why we should limit the autonomy of AI-enabled weapons