In Situ PROTAC Synthesis Enabled by Pathologically Activated Bioorthogonal Catalysis for Precision Cancer Therapy

D Dilan Ouyang (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry) R Rongjin Yang (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry) Y Yuhang Yao (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry) F Fang Jiang (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry) S Sijie Song (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry) Y Yuheng Yang (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry) E Edikan A. Ogunnaike (Department of Biomedical Engineering, Emory University, 1760 Haygood Drive, NE, Atlanta, Georgia 30322, United States) Z Zhitong Chen (Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology) Z Zhaowei Chen (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry) H Huanghao Yang (New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry)

Article Details

Volume / Issue Vol. 147, Issue 43
Published October 29, 2025
Pages 39987-39998
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (10)

D

Dilan Ouyang

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry

R

Rongjin Yang

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry

Y

Yuhang Yao

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry

F

Fang Jiang

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry

S

Sijie Song

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry

Y

Yuheng Yang

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry

E

Edikan A. Ogunnaike

Department of Biomedical Engineering, Emory University, 1760 Haygood Drive, NE, Atlanta, Georgia 30322, United States

Z

Zhitong Chen

Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology

Z

Zhaowei Chen

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry

H

Huanghao Yang

New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry