Browse Articles

Multipotential rhizobacteria simultaneously mitigate salinity stress and improve growth and physiological traits in black cumin (Nigella sativa L.)

The impact of health beliefs on treatment decision conflict through treatment expectations mediation in patients with lumbar disc herniation

Focal adhesion assembly and cell migration require myoferlin in PDAC cell lines

A scaled physical model approach to simulate nonpoint source pollution in sloping landscapes for designed ecology

Ultrasensitive electrochemical biosensor based on MXene quantum dots for prostate cancer biomarker detection

Tensile properties of the neutron irradiated HT-9 ACO-3 duct

Experimental investigation of heat transfer coefficient in pool boiling of hybrid nanofluid over grooved surfaces

Abstract Heat transfer in pool boiling is known as a complex and critical process in thermal systems. Considering the escalating need for higher efficiencies, using nanofluids as an efficient fluid in addition to modifications to surface geometry- particularly grooved surfaces- has been identified as an effective strategy for enhancing the heat transfer coefficient. This research seeks to explore the experimental effects of a hybrid graphene oxide-iron oxide/water nanofluid combined with grooved surfaces on the convective heat transfer coefficient during pool boiling. Tests were performed using a hybrid nanofluid with a 0.05% volumetric concentration on surfaces featuring diverse groove configurations. The findings demonstrated that the use of hybrid graphene oxide-iron oxide/water nanofluid alongside grooved surfaces substantially enhances the heat transfer coefficient. This enhancement stems from the synergistic influence of nanoparticles and surface geometry on the boiling process, coupled with increased turbulence in the liquid boundary layer. Among the tested configurations, the circular surface in the hybrid nanofluid exhibited the highest heat transfer coefficient improvement. Compared to a smooth surface with deionized water, the heat transfer coefficient increased by 67%. This study offers promising insights for advancing heat transfer technologies and designing advanced cooling systems. It also introduces the use of hybrid nanofluids along with engineered surfaces as a new approach to optimizing thermal processes.

ACPA prevents lung fibroblast-to-CAF transformation by reprogramming the tumor microenvironment through NSCLC-derived exosomes

Hybrid deep learning with attention fusion for enhanced colon cancer detection

Marine reef soundscape monitoring with fiber-optic distributed acoustic sensing

Mitigating crop modeling uncertainties through machine learning in drylands

Microbial associations and viruses on the risk of celiac disease (MAVRiC): a longitudinal post-hoc case-cohort study

Semi analytical solution strategy for fractional Fornberg Whitham equation using Temimi Ansari method

The role of theory of mind in how increasing preschoolers’ self-esteem affects their materialism: an experimental study

Abstract This study tested the hypothesis that enhancing preschoolers’ self-esteem in the domains of competence and social acceptance would reduce materialistic tendencies, especially in children with a developed Theory of Mind (ToM). A total of 239 children, 107 girls and 132 boys from Polish preschools participated in an experimental design. Before conducting the main study, a pilot study with 67 preschool children (36 girls and 31 boys) was carried out to validate the effectiveness of the self-esteem manipulation, confirming its success in enhancing children’s state self-esteem in the targeted domains. The results of the main study supported the preregistered hypothesis, showing that self-esteem enhancement reduced materialism but only among children with well-developed ToM. These findings provide insight into how self-perceptions and cognitive abilities, such as ToM, influence materialistic tendencies in young children, highlighting the value of early interventions to foster self-esteem. The results suggest that boosting self-esteem can be an effective strategy for reducing materialistic tendencies in preschoolers, particularly for those with developed Theory of Mind.

Classifying the tumor immune microenvironment in cervical cancer based on nuclear cytoplasmic consistent genes

Abstract Treatment options for advanced or recurrent cervical cancer (CC) remain limited, highlighting the urgent need for effective molecular biomarkers and therapeutic strategies. This study investigates nuclear-cytoplasmic consistent genes (NCCGs) in CC and other epithelial-derived malignancies, exploring their potential in molecular subtyping, prognosis evaluation, and therapeutic response prediction. NCCGs were identified using single-cell sequencing and single-nucleus RNA sequencing data. Through Cox regression and single-sample gene set enrichment analysis, TCGA-CESC cohort were stratified into high-risk (HRG) and low-risk (LRG) groups. Pan-cancer analysis of 14 TCGA epithelial-derived malignancies, including BLCA and BRCA, validated the classification capability and prognostic relevance of NCCGs. Clinical utility in predicting chemotherapy and immunotherapy responses was assessed using GSE168009 and IMvigor210CoreBiologies cohorts. NCCGs effectively stratified CC cohort into HRG and LRG. LRG demonstrated significantly better survival (HR = 3.24, 95% CI 1.57–6.7) and higher immune scores, including elevated CD8 + T and memory CD4 + T cell levels. Pan-cancer analysis confirmed NCCGs’ ability to differentiate HRG and LRG and associate with overall survival. LRG also showed greater sensitivity to PD-1/CTLA4 inhibitors and chemotherapeutic agents (e.g., Panobinostat and Doxorubicin). The NCCG-based risk score showed robust accuracy in predicting chemotherapy and immunotherapy efficacy. This study reveals the molecular mechanisms and clinical significance of NCCGs in CC and epithelial-origin cancers. NCCGs hold value in molecular classification, prognostic assessment, and predicting therapeutic responses, offering new markers and targets for precision medicine.

Deep neural networks and deep deterministic policy gradient for early ASD diagnosis and personalized intervention in children

Prevalence and associated risk factors of probable PTSD among internally displaced people in Southwest Ethiopia

Somatostatin regulates the clock sensitivity to evening light

Reassessing neolithic subsistence in Northern Italy through a critical review and new evidence from Molino Casarotto

Abstract This paper delves into the intricate nature of neolithic subsistence economies in northern Italy by providing a comprehensive overview of all previously edited data, quantitatively compared, including plant macroremains, faunal remains, and aquatic resources. Additionally, it introduces new findings from the site of Molino Casarotto, recently investigated as part of the ERC CoG GEODAP project, through an interdisciplinary approach that combines carpological analysis, phytolith analysis, and archaeozoological studies of both terrestrial and aquatic fauna. This wetland settlement, with material culture fully representative of the middle neolithic Square-Mouthed Pottery (SMP) culture, showcases an economy primarily based on hunting, fishing, gathering molluscs and wild fruits, with water chestnut serving as the staple food. The rare presence of bone remains from domestic animals and a few cereal grains indicates access to food from a agro-pastoral economy. However, the absence of chaff remains, confirmed by phytolith analysis, suggests that cereal cultivation and processing did not occur on site. These findings, within the broader context of the cultural and environmental diversity of the northern Italian Neolithic, challenge the rigidity of concepts often used to describe Neolithization processes. The emerging picture is non-linear and complex, both chronologically and geographically, with local peculiarities that push to abandon a dichotomous view of foraging versus agricultural economy.

Evaluating the morality of violence against robots