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Experimental and statistical analysis of the block orientation effect on the mechanical behaviour of bimrocks
A Thermally and Photochemically Stable Fluorescent Radical-type Mechanophore for Durable Mechanoresponsive Polymers
Repurposing SARS CoV 2 ligands identifies salvianolic acid C as potential antiviral candidate against human metapneumovirus through computational study
Tracking mangrove restoration using a biogeochemical soil health index and ecosystem service indicators
Discovery of a Copper-Binding Carbohydrate-Binding Module Regulating the Activity of Lytic Polysaccharide Monooxygenases
Development and validation of a nomogram incorporating YpT stage for predicting ypN0 using multicenter data in clinically node-positive breast cancer
Abstract Recent studies have demonstrated that breast pathological complete response (pCR) can be accurately diagnosed preoperatively using image-guided needle biopsy after neoadjuvant chemotherapy (NAC), underscoring the value of incorporating ypT stage into prediction models for axillary response (ypN0). Based on this evidence, we developed and externally validated a nomogram to predict ypN0 in patients with clinically node-positive (cN+) breast cancer treated with NAC. This retrospective, multicenter study included 609 patients with cN + breast cancer who underwent NAC followed by surgery. A nomogram was developed using a training cohort (n = 330) and validated in an independent cohort (n = 279). Diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration plots, decision curve analysis (DCA), and positive predictive value (PPV). The nomogram incorporated five predictors: ypT stage, cN stage, hormone receptor status, HER2 status, and post-NAC cN stage. It showed strong discriminative ability, with bias-corrected AUCs of 0.858 in the training cohort and 0.855 in the validation cohort. Calibration and DCA confirmed good model performance. PPV exceeded 0.90 when the nomogram-predicted probability was ≥ 0.7 in both cohorts. This nomogram demonstrated high diagnostic accuracy for predicting ypN0 and may support the selection of candidates for axillary surgery de-escalation based on post-NAC biopsy findings. Prospective validation using biopsy-confirmed pCR is warranted.
COSMO-RS prediction and validation of gingerol and shogaol extraction from Zingiber officinale var. rubrum using natural deep eutectic solvents
Decomposition of socioeconomic inequalities in zero-dose children aged 12–23 months in India
Enhanced real-time 6d pose estimation for automatic recovery of in-flight UAVs using distance-aware keypoint heatmaps
Dihydroxy Terpene Synthase: Spatiotemporally Precise Manipulation of Water-Mediated Dihydroxylation via Stepwise Quenching of Carbocations
Periplaneta americana glycoprotein alleviates fatigue through modulation of oxidative stress and gut microbiota
Oxoaporphine-Metformin Rhodium(III) Mixed Complex Achieving Dual Antidiabetes and Anticancer Effects by Interfering with Glucose Metabolism Reprogramming
Mechanical properties and energy dissipation mechanism of sandstone with cross-cutting joints under uniaxial loading
Dynamically Chiral Expanded Helicenes
Control of non-volatile magnetic properties of Fe/CoO grown on a piezoelectric substrate
Abstract In this study, we investigate the piezoelectric modulation of magnetic properties in an Fe/CoO bilayer grown on a Cr-buffered PMN-PT(001) substrate. An initial application of an electric field across the substrate has induced a non-volatile change in the coercive field of Fe/CoO. Subsequent voltage applications further modified the coercive field of Fe/CoO, maintaining the non-volatile effect below the blocking temperature of CoO. In contrast, no piezoelectric influence on the magnetic properties was observed in the Fe single layer grown on Cr/PMN-PT. X-ray magnetic linear dichroism measurements confirmed that the piezoelectric-driven modulation of magnetic behavior in Fe/CoO bilayer is primarily governed by changes in the magnetic state of the CoO film.