Browse Articles

Interaction between ELMO1 DNA methylation and Med31 promotes H. pylori-induced gastric cancer EMT and intestinal metaplasia via M2 polarization

Catalyst-Free Radical Reaction Driven by Interfacial Electric Fields in Organic Microdroplets under Ambient Conditions

Non-reassuring fetal heart rate and associated factors among laboring mothers at southern public hospitals in Ethiopia: a poisson regression model

Optimizing Stability in Dynamic Small-Molecule Binding Proteins

A method for magnetic resonance splenomegaly image segmentation based on large-kernel multi-scale attention mechanism

Monomer Isolation from Oligomeric Proteins within Coordination Cages to Study Interface Ligand Binding

In situ growth rates of cold-water corals fouling oceanographic moorings in the Central Mediterranean Sea

Mechanochemical Acceptor Engineering for NIR-I and NIR-II Fluorophores Enabling Orthogonal Ureter-Vascular Image-Guided Surgery

FA-DeepMSM: a few-shot adapted interpretable multimodal survival model for improved prognostic prediction in glioblastoma

Fast Discharging Stabilizes Electrochemical Interfaces: Achieving Close-to-Unity Reversibility in “Dendrite-Forming” Battery Electrodes

Research on coupling coordination of new quality productive forces and innovation resource allocation based on MLP neural networks

Abstract The synergistic development of new quality productive forces (NQPF) and innovation resource allocation is critical for achieving sustainable and high-quality economic growth. Using provincial data from 2012 to 2022 in China, this study constructs the evaluation framework for NQPF and innovation resource allocation, and employs an unsupervised dual-tower multilayer perceptron (MLP) neural network model to measure the coupling coordination degree. And the spatial differentiation and dynamic evolution of the coordinated degree are further explored. The results demonstrate that the MLP approach offers superior performance in identifying long-term trends while remaining robust to short-term fluctuations. Despite remaining at a primary stage, the overall coordination degree exhibits a distinct upward trajectory. Spatial disparities are primarily driven by interregional differences, with the eastern region exhibiting short-term positive development cycles, the central region showing steady catch-up progress, and the western region facing challenges of marginalization. Moreover, significant spatial spillover effects highlight the influence of geographical proximity, underscoring the importance of cross-regional cooperation and innovation resource sharing.

Expedient Modular Assembling of Chiral η ⁶ -Benzene Ligands: Empowering Ruthenium-Catalyzed Asymmetric C–H Activation

Zinc and hydroxyapatite co-localize during in vitro E. coli biofilms mineralization

Abstract Biofilms are biological materials that form as bacteria protect themselves from environmental challenges secreting extracellular matrix and accumulating minerals under specific conditions. To understand biofilm formation and mineralization, we grew Escherichia coli on agar plates containing a nutritive and mineralizing medium. Previous studies showed that the alkaline phosphatase (ALP) present in E. coli biofilms leads to hydroxyapatite precipitation in such conditions. Here, we introduced X-ray fluorescence techniques as powerful tools to analyze the composition of mineralized biofilms in two and three dimensions. In addition to calcium and phosphate, we found that the traces of zinc introduced via the nutrients and bacteria, also accumulates in the mineralized regions. Wide-angle X-ray scattering performed on dry mineralized biofilm powder also revealed a shortening of the hydroxyapatite crystal lattice, which could indicate partial substitution of calcium by zinc. Using an abiotic model, we reproduced enzymatic hydroxyapatite mineralization with pure ALP, without bacteria nor extracellular matrix. In this model, hydroxyapatite distortion increased with zinc concentration, whereas crystal size decreased. Since zinc is a ubiquitous element that is essential to bacteria metabolism but also antibacterial, these results are fundamental for biofilm research and call for further studies on zinc management in biofilms.

Unlocking Plasmonic Hot Electron Utilization on Palladium Nanoparticles via Modulation of the Bimetallic Interface for Enhanced Photocatalysis

Putative long range mossy fiber sprouting and regional cytochrome c oxidase alteration in the hippocampus of patients with mesial temporal lobe epilepsy

Erratum: Koloski et al., “Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task”

Three tips for scientific writing: a guide for graduate students

Ultrafast Mass Spectrometry Imaging via Laser-Based Mass Spectrometry Microscopy

Deglycosylation induces a novel distal conformation in the mannose receptor CD206

Spatiotemporal Cascade Targeting from the Cell Membrane to the Endoplasmic Reticulum for Chemoimmunotherapy via the Cyclometalated Iridium-Fatty Acid Scaffold