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Spectroscopic Characterization of the Charge-Separated Zwitterionic State Responsible for the Excimer-like Emission of a Luminescent Diradical
APOBEC3B enhances the efficacy of PARP inhibitors in elimination of ovarian cancer stem cell
Abstract Late detection and tumor recurrence are major factors driving the lethality of high-grade serous ovarian carcinoma (HGSOC). PARP inhibitors (PARPi) have achieved significant clinical efficacy by selectively targeting DNA repair deficiencies in HGSOC patients with BRCA mutations and homologous recombination deficiency (HRD). However, a subset of patients ultimately develops resistance to PARPi, necessitating alternative effective treatment options. The mutational signatures of APOBEC3 family of DNA deaminases are widespread across a broad array of cancer types. Here, we report that cancer stem cell (CSC)-like tumorspheres exhibit reduced A3B expression compared to non-CSC adherent counterparts. Importantly, inhibition of A3B leads to PARPi resistance, elevated frequency of CSCs, and enhanced expression of stemness factors. In addition, we found that high A3B-expressing cells are under strong replication stress and thus synergize efficiently with PARPi. These studies reveal the important role A3B plays in regulating PARPi response.
Decoding the Nested, Multicycle Mechanism of Ni-Catalyzed Redox-Neutral Cross-Coupling through Temperature Scanning Reaction Calorimetry
Hierarchical contextual information aggregation for polyp segmentation
How ageing harms the body’s response to raging infection
Light-Induced NH <sub>4</sub> <sup>+</sup> Deprotonation Drives NH <sub>4</sub> <sup>+</sup> /H <sup>+</sup> Hybrid Storage Toward Near-Theoretical Capacity in NH <sub>4</sub> V <sub>4</sub> O <sub>10</sub> Electrodes
A probabilistic assessment of dietary heavy metal exposure and its temporal trends in Chongqing China from 2012 to 2022
Defect-Assisted Recombination in Semiconductors and Photovoltaic Device Parameters from First Principles
Effect of ice cover roughness on local scour around bridge piers
Stereoselective Dihalogenation of Alkynes to Access Enantioenriched <i>Z</i> -Vicinal Dihaloalkene Atropisomers
Novel optical measurement technique for antimicrobial photodynamic therapy using Scattered Light Integrating Collector (SLIC)
Abstract Advancing new treatment modalities for microbial infections is a priority, given the threat of antimicrobial resistance. Current work includes the development of new non-traditional treatments, including antimicrobial photodynamic therapy (aPDT). Improvements in the field include innovative technologies that allow screening and optimization of the treatment. In this work it is shown how the Scattered Light Integrating Collector, a novel technology that optically measures bacterial growth in real time, can be used for rapid screening of aPDT using Organic Light Emitting Diodes (OLEDs) as the light source. This technology allows rapid screening of different concentrations of the photosensitizer and real-time observation of the effect of aPDT on Staphylococcus aureus . Evaluation of aPDT efficacy using methylene blue and OLEDs as the light source showed significant inhibition of the growth of S. aureus (3.06, 3.80, 4.24, 4.98 and 4.84 log 10 reduction for the concentrations of MB of 1, 2, 4, 8 and 16 µM, respectively). The application of SLIC as a novel technology for evaluation of aPDT is a promising advance that will allow rapid optimization of the treatment.