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Controlling effects of depositional microfacies on reservoir development in the Es3s formation, Jin9 Block, Jinjia oil field

Genetic structure of Rattus rattus populations in an endemic plague focus in Madagascar: Implications for rodent surveillance and management

Background Plague remains a major public health concern in Madagascar. In the Central Highlands, where the disease is still endemic, the black rat ( Rattus rattus ) is the main reservoir of the causative agent Yersinia pestis . Understanding its population dynamics and structure is therefore crucial to inform control strategies, as dispersal may greatly limit the effectiveness of local interventions during outbreaks. In this context, our study investigates the genetic structure of R. rattus populations at a fine geographical scale and across two different years. Methodology/Principal findings Sampling was conducted in six villages of the Azobenzene district, both inside houses and in habitat outside villages. A total of 480 individuals, captured in March – May 2019 and 2020, were genotyped at 18 microsatellite loci. Our results showed that genetic diversity levels were relatively similar among villages and years. However, subpopulations living outside villages displayed significantly higher genetic diversity and lower genetic differentiation levels than those from inside houses, indicating larger effective population sizes outside villages in the cultivated habitats. These findings suggest more restricted movement among rat subpopulations from the houses, and greater connectivity among subpopulations living outside villages. However, overall genetic differentiation was rather low, suggesting extensive dispersal of rats at the scale of the district, facilitating rapid recolonization after local control efforts. Conclusion Because of the recolonization problem, an integrated approach combining flea control inside houses together with measures to reduce human-rodent contact would thus appear more appropriate than rodent control only to limit plague transmission.

Health related self efficacy and associated factors among patients with chronic diseases at university of Gondar comprehensive specialize hospital

Abstract Chronic diseases result from the interaction of genetic, physiological, environmental, and behavioral factors. The death rate from chronic diseases has been increasing, and they are the leading cause of disability and preventable deaths. Behavioral risk factors are central to the progression of chronic diseases, and strong Health-related self-efficacy (HRSE) is crucial for reducing burdens through effective measures of self-management. This study aimed to assess HRSE and associated factors among patients with chronic disease at the University of Gondar Comprehensive Specialized Hospital (UOGCSH). A cross-sectional study was conducted at the UOGCSH chronic outpatient department from October 24 to December 30, 2024, among patients with chronic disease who had regular follow-up. Data were collected using the health-related self-efficacy tool and an interviewer-administered method. Adjusted Odds Ratios with 95% confidence intervals were used to report the strength of associations. Significance was set at P -value < 0.05. The Hosmer–Lemeshow goodness-of-fit test was used to assess the model’s fit. A total of 410 patients (response rate 97.16%) participated in this study, with a mean ± SD age of 49.7 ± 13.77 years. Of all participants, 105 (25.6%, 95% CI: 21.2–30) had a good HRSE. Participants reported higher confidence in resisting alcohol. The multivariable binary logistic regression indicated that higher educational levels and comorbidities (AOR = 0.524, 95% CI: 0.309–0.88) are associated with higher odds of good HRSE. However, patients diagnosed with epilepsy (AOR = 0.081, 95% CI: 0.01–0.659) have lower HRSE than diabetes patients. Only one-quarter of patients with chronic diseases have good HRSE. Educational level, type of diagnosed disease, and comorbidities were associated with HRSE. Healthcare services should strengthen their strategies to improve HRSE through patient education and counseling, which might improves the management of behavioral risk factors among patients with chronic diseases.

Dietary patterns and their associations with obesity among 4–9-year-old children in the United Arab Emirates: A cross-sectional study

Dietary patterns constitute a modifiable lifestyle exposure, affecting obesity among children. This study aimed to identify and characterize dietary patterns amongst young school-aged children in the UAE and investigate their association with obesity. A cross-sectional survey of 4–9-year-old children (n = 426) was conducted in the 3 major Emirates of the UAE. Socio-demographic characteristics and anthropometric measurements were obtained. Dietary assessment was performed using the 24-hour recall method. Derivation of dietary patterns was carried out using factor analysis. Of the study sample, 19.5% were overweight/at risk of overweight, and 5% were obese. Two main dietary patterns were derived: “Healthy Pattern”, marked by higher consumption of fruits and vegetables, olive oil, and whole grains, and “Western Pattern,” characterized by higher intakes of fast food, salty snacks, sweets, and sugar-sweetened beverages. The Healthy Pattern demonstrated negative correlations with total energy, saturated and trans-fat intake, and a positive correlation with dietary fiber intake. The Western Pattern was positively correlated with proteins, cholesterol, saturated and trans-fat intake, and negatively correlated with dietary fiber intake. Higher scores of the Healthy Pattern were associated with lower BMI-for-age Z scores. These findings provide evidence for the development of culture-specific nutrition programs for curbing the obesity epidemic amongst children in the UAE.

Synergistic reproductive toxicity of lambda-cyhalothrin and thiamethoxam via oxidative stress and blood–testis barrier dysfunction in rats

Abstract Excessive pesticide use regularly pollutes the environment and endangers both human and animal health. The current study aimed to examine the main mechanism by which the combined action of pyrethroids, such as lambda-cyhalothrin (LC), and neonicotinoids, such as thiamethoxam, induced testicular toxicity and oxidative stress. Four groups of adult male rats were formed: control, Lambda-cyhalothrin (LC; 8 mg/kg B.W.), Thiamethoxam (TMX; 156 mg/kg B.W.), and LC + TMX groups. For 21 days, the rats received their doses orally. Results showed that LC and/or TMX caused significant alterations in body weight, gonadosomatic index, sperm quality, hormones, lipid peroxidation, DNA toxicity, and enzymatic and non-enzymatic antioxidants. Furthermore, testicular tissue showed biochemical, genes expression (steroid-forming acute regulatory protein (StAR), Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17a), luteinizing hormone receptor (LHR), cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc), scavenger receptor class B type I (SR-B1), 3β-hydroxysteroid dehydrogenase (3β-HSD), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), Claudin-11, Occludin and ZO-1), and ultrastructural abnormalities. In conclusion, rats given both LC plus TMX had strong adverse effects, suggesting oxidative stress and reproductive toxicity.

Why do Canadians host refugees? A sequential explanatory mixed-methods study protocol

Refugee homestay hosting, in which private citizens or permanent residents provide temporary accommodation and informal support to refugees and displaced persons, is increasingly used as a community-based response to housing insecurity, social isolation, and settlement barriers. Although prior scholarship has examined refugee experiences within hosting arrangements, comparatively little is known about the motivations, readiness, attitudes, empathy, satisfaction, and advocacy behaviours of hosts, or about the organizational supports required to sustain hosting in Canada. The study is informed by hospitality studies and collective action perspectives. This protocol describes a 36-month sequential explanatory mixed-methods study of three phases designed to examine why Canadians host refugees and how refugee homestay hosting can be strengthened through evidence-informed and co-designed strategies. Phase 1 will include the administration of a national survey to current and former Canadian refugee homestay hosts to examine relationships among hospitableness, attitudes toward refugees, empathy, readiness to assist, satisfaction, and advocacy for refugee hosting. Quantitative data will be analyzed using descriptive and inferential statistics. Open-ended survey responses will be thematically analyzed. Phase 2 will use qualitative descriptive methods to conduct semi-structured interviews with 20–25 Canadian hosts and service providers to explore motivations, practices, needs, challenges, trauma- and gender-responsive considerations, and recommendations for service and policy improvement. Phase 3 will use group concept mapping and co-design sessions with 20–25 hosts and service providers to prioritize needs and develop multi-level action-oriented recommendations, including a host support toolkit, service provider guidelines, and policy strategies. Findings are expected to inform refugee-serving organizations hosting practices and programs to sustain safe, inclusive, and effective refugee homestay hosting in Canada.

Sex differences in metabolic remodeling and skeletal muscle regeneration following cardiotoxin-induced injury

Abstract Skeletal muscle regeneration is a dynamic biological process that requires metabolic remodeling, satellite cell activation, inflammatory responses, and tissue remodeling. Although biological sex is recognized as an important determinant of skeletal muscle regeneration, whether males and females utilize distinct metabolic programs during regeneration remains poorly understood. In the present study, we investigated sex-dependent differences in metabolic remodeling and regenerative responses following cardiotoxin (CTX)-induced skeletal muscle injury in mice. Targeted metabolomic analysis performed at 7 days post-injury (DPI) revealed clear sex-dependent metabolic remodeling. Principal component analysis and pathway enrichment analysis identified glycolysis/gluconeogenesis as the most significantly altered metabolic pathway following injury. Male mice exhibited higher levels of several glycolytic, tricarboxylic acid (TCA) cycle, and amino acid metabolites than female mice. In contrast, female mice showed greater expression of Pax7, Myf5, and Myod1, together with increased Pax7-positive cells, greater Cyclin D1 staining, and higher expression of Ccne1, Cdc2, and Cdk4. Local inflammatory responses also differed between sexes, with distinct temporal patterns of MCP-1, IL-6, TNF-α, and CD45 during regeneration. Histological analyses demonstrated greater lipid accumulation in female muscle at 7 DPI, whereas both sexes exhibited comparable percentages of centrally nucleated fibers and similar restoration of muscle architecture by 21 DPI. Together, these findings indicate that biological sex is associated with differences in metabolism, satellite cell-associated responses, inflammatory responses, and tissue remodeling during skeletal muscle regeneration. Although males and females ultimately achieved comparable structural recovery, the regenerative process differed substantially during the early phase after injury. These findings provide additional insight into the biological processes underlying sex-dependent skeletal muscle regeneration and establish a foundation for future studies investigating the mechanisms linking metabolism to regeneration.

Identification of risk profiles among persons attending a sexually transmitted infection clinic in Estonia

Background While generalized STI prevention guidelines exist, individuals present with diverse interconnecting risk behaviors and needs. This cross-sectional study used latent class analysis to identify distinct behavioural profiles among men and women undergoing STI testing and to examine their potential implications for STI prevention. Methods Data was collected by questionnaire from 1171 individuals seeking STI testing at the North Estonia Medical Centre between August 2022 and October 2023. Latent class analysis was applied to identify subgroups based on eight relevant STI risk variables. Separate models were fitted to men and women. Results We propose three latent classes for both sexes. Among men, three classes were identified: “multiple partners; elevated behavioural risk” (62.4%); “predominantly monogamous; fewer behavioural risk indicators” (21.9%); and, “multiple partners; previous STI history; concentrated co-occurring risk” (15.7%). Women were categorised as follows: “new sexual partners; inconsistent condom use” (41.6%); “multiple partners; previous STI history; concentrated behavioural risk” (30.2%); and, “predominantly monogamous; possible partner-related exposure” (28.2%). The identified profiles demonstrated heterogeneity in sexual behaviour, condom use, prior STI history, and substance use across STI clinic attendees. Conclusions The identified behavioural profiles highlight how co-occurring risk factors cluster within STI clinic populations and may help contextualise prevention discussions alongside individualized clinical assessment. These findings may support prevention discussions addressing partner communication, condom use, substance use, IPV awareness, and partner notification.

Efficiency-fairness tradeoff in distributed satellite scheduling

Prevalence and risk factors for colorectal neoplasia in a self-selected Vietnamese screening cohort undergoing self-funded colonoscopy

Objective Several studies have investigated colorectal neoplasia (CRN) in Vietnamese patients who present with lower gastrointestinal symptoms. However, data on subjects without symptoms is limited. This study aimed to determine the prevalence and risk factors for CRN in asymptomatic Vietnamese adults. Methods This was a prospective, cross-sectional, single-center study. Participants were consecutively recruited from asymptomatic individuals who were self-selected to undergo self-funded screening colonoscopy. CRN was defined as the presence of adenoma, sessile serrated lesions, or colorectal cancer. Advanced CRN included adenoma ≥ 1 cm, with villous features or high-grade dysplasia; sessile serrated lesion ≥ 1 cm or with dysplasia; traditional serrated adenoma; or colorectal cancer. Multivariable logistic regression was performed to identify independent risk factors for CRN, adjusting for age, sex, BMI, family history of colorectal cancer, smoking status, and alcohol consumption. Results There were 714 patients, with a median age of 51 (18–79 years) and a female-to-male ratio of 1:1.46. In this screening-attending cohort, the prevalence of overall CRN and advanced CRN were 26.2% and 9.0%, respectively. In the multivariate analysis, factors significantly associated with CRN included increasing age per 10-year increment (odds ratio [OR]: 1.76; 95% confidence interval [CI]: 1.47–2.11; p < 0.001), body mass index ≥ 23 kg/m 2 (OR: 1.70; 95% CI: 1.16–2.50; p = 0.006), alcohol consumption (OR: 1.83, 95% CI: 1.10–3.04, p = 0.020), and family history of colorectal cancer (OR: 2.43; 95% CI: 1.36–4.37; p  = 0.003). Conclusions CRN was prevalent in this self-selected screening-attending cohort in a private clinical setting. Increasing age, overweight, and family history of colorectal cancer were independent factors associated with CRN.

A conventional content analysis of clinicians’ perspectives on patient-based factors that influence surgical prioritization of abdominal trauma

Abstract Operative triage of abdominal trauma, whether blunt or penetrating, remains a major challenge in emergency care. Although quantitative decision-support tools, such as Pediatric Emergency Care Applied Research Network (PECARN) rule, Focused Assessment with Sonography in Trauma (FAST), Shock Index, Pediatric Age-Adjusted (SIPA), and Blunt Abdominal Trauma Scoring System (BATSS), are widely used, they do not fully capture the complex clinical reasoning and experiential judgment required for real-world decision-making. This limitation is particularly important because blunt and penetrating abdominal trauma differ substantially in their pathophysiology, injury patterns, and management priorities. This qualitative study explored the patient-related factors influencing surgical prioritization (operative triage) of abdominal trauma from the perspectives of clinicians involved in trauma care. This qualitative study used a conventional content analysis approach. Ten clinicians with direct experience in abdominal trauma triage were purposively recruited from teaching hospitals affiliated with Dezful University of Medical Sciences, Iran. Participants included five specialist physicians (two anesthesiologists, one general surgeon, and two emergency medicine physicians) and five nursing and allied health professionals (two nurses with PhDs in Nursing, one nurse with a Master’s degree, one surgical technologist with a Master’s degree, and one Master’s-level anesthesia professional). Data were collected through ten in-depth, semi-structured interviews and analyzed manually using the five-step content analysis method proposed by Graneheim and Lundman. Trustworthiness was established according to Lincoln and Guba’s criteria. Analysis identified three main categories and ten subcategories influencing operative triage of abdominal trauma: physiological status (vital signs, respiratory distress, indicators of shock, level of consciousness, and associated neurological injury), individual and contextual characteristics (age, pregnancy, and comorbidities), and injury severity and pattern (limb injuries, extra-abdominal trauma, and head injury). Clinicians consistently distinguished between blunt and penetrating abdominal trauma during surgical prioritization. In blunt trauma, concealed hemorrhage, hemodynamic instability, and imaging findings suggestive of solid organ injury were the primary determinants of urgency. In penetrating trauma, injury trajectory, peritoneal violation, and the need for immediate surgical exploration were prioritized. Participants described operative triage as a dynamic process that integrates multiple clinical cues, contextual information, and professional experience rather than relying solely on algorithm-based protocols. Operative triage of abdominal trauma is a multidimensional clinical decision-making process that extends beyond standardized scoring systems and fixed numerical thresholds. Surgical prioritization requires the simultaneous integration of injury mechanism, physiological status, patient characteristics, and contextual clinical information. These findings underscore the importance of combining evidence-based protocols with experienced clinical judgment, particularly when managing patients with multisystem trauma, complex injuries, or atypical presentations. Incorporating these factors into trauma education, clinical training, and future decision-support systems may improve the accuracy, consistency, and timeliness of operative triage for patients with abdominal trauma.

Retraction: Kallikrein Gene-Modified EPCs Induce Angiogenesis in Rats with Ischemic Hindlimb and Correlate with Integrin αvβ3 Expression

Multi-scale investigation of hybrid fiber-reinforced concrete for mitigating early-age shrinkage cracking in bridge deck pavements

Abstract Early-age shrinkage cracking in concrete bridge deck pavements is a pervasive infrastructure challenge, with approximately 42% of decks developing cracks within the first week after construction. These defects raise long-term maintenance costs and weaken structural durability. This study assesses hybrid fiber-reinforced concrete, or HFRC, as an alternative to conventional reinforced concrete, using material property tests, two-dimensional digital image correlation (2D-DIC), and restrained shrinkage tests to compare crack resistance. Key findings show HFRC outperforms conventional concrete. Full-field 2D-DIC analysis revealed significant strain concentrations along the steel bars in traditional pavement layers. This suggests that the stiffness mismatch between the high-modulus steel reinforcement and the concrete matrix, coupled with internal restraint effects, may induce localized stress concentrations that guide the development of macro-cracks. Restrained shrinkage tests found traditional pavements formed more than 50% of their cracks within three days, while HFRC reduced total crack area by over 93% after 14 days, bringing it to less than 1/16 of conventional levels with notably smaller crack widths. This research identifies HFRC as a material-efficient alternative with potential durability benefits for effectively mitigating early-age cracking in bridge deck pavements. Its enhanced performance is attributed to the improved compatibility between material-scale deformation demands and system-level boundary restraints, which is interpreted to prevent restraint-induced stress concentrations from reaching the macroscopic cracking threshold.

A scoping review on emerging biomarkers in inflammatory bowel disease: Towards precision medicine in diagnosis and therapeutic management

Background Inflammatory Bowel Diseases (IBD) are chronic conditions presenting significant diagnostic and management challenges. Current invasive methods and traditional biomarkers often lack sufficient accuracy and fail to address the disease’s heterogeneity and unpredictable therapeutic responses. This necessitates more precise, personalized clinical tools. Methods This scoping review synthesized recent findings on emerging biomarkers for IBD. We focused on technological advances in omics platforms (genomics, transcriptomics, proteomics, metabolomics, microbiomics), artificial intelligence, biosensors, and imaging techniques. Analysis identified biomarker potential for early diagnosis, disease activity monitoring, progression prognosis, and therapeutic response prediction. The review adhered to PRISMA-ScR guidelines and was registered with the Open Science Framework (OSF). The search encompassed five major databases: PubMed/MEDLINE, Scopus, Web of Science, Embase, and Google Scholar. Results Studies demonstrate vast potential in non-invasive biomarkers for refined early diagnosis, optimized disease monitoring, and treatment response prediction. Key findings include metabolomic and gut microbiota profiles, genetic and epigenetic markers, and AI integration of complex data. These approaches promise to overcome conventional indicator limitations. From 784 initial records, 27 articles were included, published between 2021 and 2025. Conclusion Emerging biomarkers are fundamental for the transition to precision medicine in IBD. Their implementation aims to enhance pathogenesis understanding, personalize therapies, and improve patient quality of life, establishing pathways for more effective, individualized management approaches.

CuO/ZnO nanocomposites synthesized using Ensete ventricosum extract: antibacterial and antioxidant activity

Abstract Most infection-causing pathogens have developed resistance to conventional antibiotic treatments, while free radicals can also induce cellular damage by disrupting essential biomolecules and cellular structures. Binary metal oxide nanocomposites have attracted increasing attention due to their unique physicochemical properties, enhanced stability, and superior biological and catalytic performance compared to single metal oxides. In this study, CuO/ZnO nanocomposites were successfully synthesized via a green, eco-friendly approach using Ensete ventricosum leaf extract, yielding well-defined heterostructures with enhanced biological performance relative to the individual oxides. The UV-Vis spectrum showed an absorption peak at 421 nm with a band gap energy of 3.25 eV, which is slightly lower than that of pure ZnO, indicating a strong interaction between CuO and ZnO phases. The crystallite size was found to be 24.5 nm from XRD analysis, confirming the nanocrystalline nature of the material. FT-IR analysis confirmed the presence of Zn–O and Cu–O stretching vibrations at 545 and 560 cm⁻¹, respectively. SEM analysis revealed slightly agglomerated particles, while EDS confirmed the presence of Zn, Cu, and O elements. The synthesized CuO/ZnO nanocomposites exhibited significant antibacterial activity against Staphylococcus aureus (22.64 mm) and Escherichia coli (19.21 mm), along with strong antioxidant activity (IC₅₀ ≈ 107.18 µg/mL), compared with CuO NPs (~ 150 µg/mL) and ZnO NPs (~ 180 µg/mL) in DPPH radical scavenging assays. These results demonstrate that the CuO/ZnO heterojunction enhances biological activity. This work provides a scalable green synthesis strategy for CuO/ZnO NCs with promising antimicrobial and antioxidant applications, highlighting the potential of plant-mediated routes for environmentally friendly nanomaterial synthesis.

Self-compassion, adverse childhood experiences and perceived stress on college students’ mental health: The role of resilience

Background The college environment presents various academic and life pressures that affect students’ mental health. Previous studies have examined self-compassion, perceived stress, and adverse childhood experiences separately, but few have integrated them within a unified resilience framework. Drawing on the stress-buffering theory, this study aims to examine the relationships among self-compassion, ACEs, perceived stress, and mental health, and to investigate the mediating role of resilience. The study develops an integrative framework that simultaneously considers risk and protective psychological mechanisms, thereby extending previous research by examining the mediating role of resilience in the associations of early adversity, stress perception, and self-compassion with mental health among university students. Methods This cross-sectional study employed an online self-report survey conducted via the Questionnaire Star platform ( www.Sojump.com ). Using a convenience sampling method, college students from two universities in China completed the Self-Compassion Scale, Adverse Childhood Experiences Scale, Perceived Stress Scale, Resilience Scale, and Mental Health Scale. A total of 657 valid questionnaires were obtained. Correlations among variables were analyzed using SPSS Statistics 26, and mediation effects were tested with Model 4 of the PROCESS 4.0 macro. Results Self-compassion was positively associated with mental health, while adverse childhood experiences and perceived stress were negatively associated with mental health. Resilience played a mediating role, linking these factors to mental health outcomes. Conclusion This study underscores the importance of resilience in mental health and provides a theoretical basis for interventions in higher education, emphasizing resilience enhancement to support student well-being.

Tri-Net: unified deep learning for skin lesion and symptom-based monkeypox detection

Retraction: Advanced machine learning-guided optimization platform for high-yield soluble expression of Pseudomonas aeruginosa exotoxin A in engineered Escherichia coli strains

Human cardiac innervation-on-a-chip platform recapitulates neurocardiac interactions and supports future disease modeling

Abstract The cardiac autonomic nervous system regulates cardiac function through innervation, and dysfunction of the neuronal and cardiovascular crosstalk has been linked to various pathologies. Here, we present a cardiac innervation-on-a-chip model by combining human induced pluripotent stem cell (hiPSC)-derived cortical neurons, postganglionic sympathetic neurons, and ventricular cardiomyocytes in a compartmentalized microfluidic device called a 3D3C chip to generate physiologically relevant in vitro brain-heart axis model. The 3D3C chip allowed successful multiculturing of the cell types in distinct compartments and formation of axonal connections between them. Using integrated microelectrode arrays (MEA), we demonstrated the progressive development of spontaneous electrophysiological activity in both neurons and cardiomyocytes over time. This subsequently allowed for the pharmacological stimulation of neuronal activity followed by axon-mediated cardiac responses and increased neurotransmitter release. Moreover, innervated cardiomyocytes exhibited both enhanced structural maturation and electrophysiological functionality in the multiculture. This advanced cardiac innervation-on-a-chip provides a powerful in vitro platform for examining disease-related mechanisms of the brain–heart axis.

Research priorities for back pain: Results from an adapted James Lind Alliance priority setting partnership

Background Knowledge gaps remain in the field of back pain research, with few systematic efforts undertaken to identify research priorities that reflect the preferences of individuals affected by the condition. The objective of this study was to identify the top 10 research priorities for back pain, as defined by individuals with lived experience of back pain and healthcare professionals. Method A James Lind Alliance Priority Setting Partnership approach was conducted in Norway. This involved (1) establishing a Steering Committee; (2) defining a scope; (3) gathering stakeholders’ evidence uncertainties about back pain using focus group interviews; (4) summarising evidence uncertainties and verifying uncertainties by checking existing evidence; (5) shortlisting evidence uncertainties using an online survey; and (6) determining the top 10 research priorities through a priority-setting workshop. Results In total, 230 questions were generated through three focus group interviews involving 12 individuals with lived experience of back pain and seven healthcare professionals. Generated questions were summarised into 37 core questions. None of the core questions had been sufficiently addressed by existing evidence (prioritising high-quality evidence, preferably systematic reviews). The shortlisting survey was completed by 284 respondents (263 individuals with lived experience of back pain (93%), and 40 healthcare professionals (14%), with some respondents identifying as both). The top 25 core questions were brought forward to the priority-setting workshop involving five healthcare professionals and four individuals with lived experience of back pain. The top research priority was “How can implementation of evidence-based treatment recommendations for back pain be ensured in the Norwegian healthcare system?”. Conclusion Adopting the JLA approach, this study has identified the top 10 research priorities for back pain from the perspectives of both individuals with lived experience of back pain and healthcare professionals. These findings should be considered a guide to research areas that are meaningful to end-users.