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GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma
Electrochemically Assisted Synthesis of Covalent Organic Frameworks via In Situ Oxidation of Alcohol Monomers
A queen odour mediates reproductive suppression in a eusocial mammal
Abstract Eusociality is exceptionally rare in mammals, and its proximate mechanisms remain poorly understood. Naked mole-rats provide a striking example, with reproduction restricted to a single queen, while all other females remain infertile 1 . Here we identify a chemical signal in queens that can regulate this reproductive hierarchy. Isopropyl myristate is a low-volatility ester that is enriched in queens and nearly absent from non-breeding animals. Isopropyl myristate is detected by peripheral and central olfactory neurons and elicits avoidance in high-ranking animals. Exposure alters levels of prolactin and progesterone in non-breeders to suppress reproduction. Daily addition of isopropyl myristate to a queenless colony prevented queen succession, whereas withdrawal triggered aggression and reproductive competition. Isopropyl myristate was also detected in breeding females of several Fukomys mole-rat species, but reaches higher levels in naked mole-rats, paralleling their extreme reproductive skew. These findings reveal a chemical cue that can mediate reproductive suppression in a mammal, linking insect and mammalian eusociality.
Correction to “Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membranes Imaging”
A Bayesian framework for longitudinal EHR and genetic discovery
Silicon-Xanthenium Scaffold for pH- and Far-Red Light Dual-Responsive Photocage
Relapse
Interplay between Slow Chirality Inversion and Slow Guest Uptake in a Triple-Helical Closed-Cage Metallocryptand
Lysing with Light: Trackable On Demand Molecular Delivery
A high-fat, low-carbohydrate diet can feed intestinal tumours
A Ferrocene Metal–Ligand Triplet Diradical with a Terminal Iminyl Group Discovered by Time-Resolved Mid-Infrared Spectroscopy
Food systems transformation would reshape global agriculture
Abstract Food systems are a major contributor to exceeding planetary boundaries 1–3 and poor quality diets are a key mortality risk globally 4 . Projected population and income growth could exacerbate these challenges 5 . In response, there are calls for transformation towards healthy and sustainable food systems 6–8 . However, the scale and distribution of the impacts of this transformation on agriculture are underexplored. Here we show that, by 2050, the transformation of food systems towards healthy diets (adoption of the EAT– Lancet reference diet), improved productivity and halving of food waste results in a fundamental restructuring of global agriculture, aspects of which break with historical trends. Scenario simulations using a multimodel ensemble of ten global economic models show a 6% median decrease in agricultural land (+1% to −26%) compared with 2020 levels. By 2050, agricultural production would be 17% lower than business-as-usual projections (−2% to −32%) and, economically, the value of this production is US$1.6 trillion (26%) lower (+8% to −58%). Within this, the value of livestock production would be substantially lower than current 2050 projections (−49% to −83%), while vegetable, fruit, nut and legume production value would increase by 23% (−33% to +106%). Results are dependent on the assumed policies to achieve the transformation scenario. We highlight a more active role for food policy to consider the benefits of such a transformation (improved population health and reduced environmental pressures) and navigate the political economy of its impacts.