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Association between lifelong physical activity, physical fitness, and quality of life in older adults in Poland
FracDet-v11: a multi-scale attention and wavelet-enhanced network for real-time pediatric wrist fracture detection
Predictors of opportunistic infections among people living with HIV: a prospective cohort study from a tertiary care setting in India
Geophysical and multi-criteria decision methods for delineating groundwater potential in coastal terrains: a study from Port Sudan
Abstract Groundwater resources in arid, semi-arid, and coastal regions are of vital importance due to the scarcity or complete absence of reliable surface water sources. Port Sudan city is now serving as the administrative capital following the country’s political instability. As a result, the city has witnessed a massive influx of internally displaced people, placing pressure on its already fragile water resources. The region is underlain by Precambrian basement terrains, restricting groundwater occurrence to structurally controlled aquifers and alluvial deposits. This study integrates gravity data analysis with the analytical hierarchy process (AHP) to delineate potential groundwater zones in the area. Structural features were extracted from gravity data using edge detection techniques, including vertical and horizontal derivatives, tilt angle derivative, and analytical signal. A density map of the identified structures was generated and integrated with other groundwater recharge-controlling factors including geology, rainfall, land use, slope, and drainage density within an AHP framework. The multi-criteria evaluation resulted in a groundwater potential map delineating three distinct zones: low (41.5%), moderate (13%), and high potential (45.5%). These zones were validated using 2D gravity inverse modeling constrained by boreholes data along two profiles. This integrated approach provided a preliminary yet effective tool for groundwater exploration in complex basement terrains and supports decision-making for further detailed hydrogeological and geophysical investigations in Port Sudan and similar arid environments. Incorporating more detailed geophysical analyses could further enhance subsurface characterization and improve groundwater potential assessments.
Correction: Bioproduction, characterization, anticancer and antioxidant activities of extracellular melanin pigment produced by newly isolated microbial cell factories Streptomyces glaucescens NEAE-H
A system for invitro inhaled/exhaled aerosol testing of personal protective equipment
Harnessing the potential of selected Himalayan species for phyto-cosmeceutical formulations guided through biochemometric analysis
A sport inspired kabaddi game optimizer for accurate parameter estimation of solar photovoltaic models
Abstract This paper proposes a Kabaddi Game Optimizer (KGO), a sport-inspired metaheuristic for accurate solar photovoltaic (PV) modelling. KGO models Kabaddi strategies (Dubki and Akraman), adaptive weights and weak-player replacement to balance exploration and exploitation. Its performance is first validated on the CEC 2017 benchmark set against seven well-known optimizers, where KGO consistently attains the best average rank. KGO is then coupled with the Newton–Raphson method to estimate parameters of single, double, and triple diode PV models and a PWP-201 PV module. Using RTC France cell and module data, KGO achieves RMSE values of 7.729857E−04, 7.43146E−04, 7.3771E−04, and 2.0529E−03 for the single-, double-, and triple-diode models, and the PV module, respectively, demonstrating accurate, robust, and fast PV parameter estimation.
Efficient optimization of noise-reducing orifice plates in nature gas pressure regulators based on adaptive multi-scale sampling-kriging model
Improved circle-SCA-BSO optimized gas turbine speed PID controller for enhanced speed tracking and interference rejection
Towards understanding the applicability of runtime moving target defense for the internet of things and cyber physical systems
ASTRID-Net: SE-enhanced triple attention deep learning framework for IoT and IIoT security
SH3BGRL proteins are thioredoxin fold–containing actin filament pointed end capping proteins (TPECs)
Abstract Cellular actin dynamics are tightly regulated by actin-binding proteins with specialized domains. Here, we identify SH3BGRL proteins as modulators of actin dynamics, characterized by their thioredoxin (Trx) fold and the absence of the canonical enzymatic site. The Trx fold is generally associated with enzymatic activity; however, in this context, it functions non-enzymatically to enhance actin nucleation, inhibit depolymerization and cap the growing pointed end of the actin filament. Our results indicate that all SH3BGRL isoforms weakly promote actin nucleation in vitro by stabilizing energetically unstable actin dimers and trimers. Using molecular dynamics simulations and assays that directly probe the pointed end of the actin filament, we show that SH3BGRL proteins efficiently inhibit actin subunit addition at the pointed end by direct association with the terminal actin subunits. However, SH3BGRL proteins are less effective at preventing subunit loss from the pointed end, but they can cooperate with tropomodulin to enhance this activity in an isoform-specific manner, indicating that all isoforms are capable of forming a tripartite complex with actin and tropomodulin. Based on our results, we propose a new and more appropriate name that reflects the function of the SH3BGRL protein family: t hioredoxin fold–containing p ointed e nd c apping proteins (TPECs).
Leukocyte telomere attrition following radiotherapy in prostate cancer: a prospective study
Author Correction: Safety evaluation of extracellular vesicles derived from hypoxia primed mesenchymal stem cells of umbilical cord and adipose tissue
MCT1 as a critical regulator of insulin signaling, energy homeostasis and podocyte function
Abstract Podocytes are highly specialized epithelial cells that play a central role in maintaining integrity of the glomerular filtration barrier. Because of their complex architecture and dynamic actin-based cytoskeleton, podocytes have substantial energy requirements, which are predominantly supported by glycolysis. Insulin signaling and glucose uptake are key regulators of cytoskeletal dynamics in these cells. Recent evidence highlights the importance of lactate metabolism in maintaining podocyte metabolic homeostasis, supported by a well-developed system for controlling lactate levels. Monocarboxylate transporter 1 (MCT1), a principal mediator of lactate transport, has emerged as a critical regulator of cellular energy balance. The present study investigated the role of MCT1 in insulin-stimulated glucose metabolism and its impact on podocyte morphology and function. Our findings showed that MCT1 inhibition impaired glucose uptake and suppressed glycolytic flux. This metabolic disruption was accompanied by alterations of the localization of key insulin signaling proteins, disorganization of the actin cytoskeleton, and an increase in permeability of the podocyte layer. Interestingly, MCT1 inhibition also triggered a compensatory shift toward oxidative phosphorylation, potentially linked to an increase in mitochondrial biogenesis. These results underscore the pivotal role of MCT1 in regulating glucose metabolism and actin cytoskeleton organization in podocytes and suggest that lactate transport is essential for preserving their structure and function. Targeting MCT1 and lactate metabolism may offer a novel therapeutic strategy for glomerular diseases that are characterized by insulin resistance and metabolic dysregulation.