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Sustainable decontamination of crude oil-contaminated soil using Sapindus mukorossi extract: A green intervention to synthetic surfactant treatment
Mechanistic insight into visible light photocatalytic removal of meropenem from wastewater utilizing nickel based LDH nanostructures with synergistic adsorption effects
Experimental and computational study of corrosion protection of carbon steel by Lavandula angustifolia extract–Zn(II) hybrid system in saline solution
Adapting to sea level rise and storms
Genotype-dependent sulfur depletion is linked to antioxidant dysfunction and growth responses to As, Cd, and Pb in Alnus glutinosa
Transcriptomic and proteomic evidence for noncanonical hydrogen sulfide metabolism and immune dysregulation in Down Syndrome
ANO1 stabilizes partial EMT to drive colorectal cancer metastasis through PI3K/AKT/mTOR and ERK signaling pathways
M-CSF priming enhances the efficiency and reproducibility of hiPSC-derived osteoclast differentiation and pharmacological responsiveness to anti-resorptive agents
Characterization of a temperate bacteriophage isolated from the ruminant-derived Streptococcus bovis/equinus complex
Abstract Although Streptococcus bovis/equinus complex (SBSEC) lysogens are prevalent in the rumen, studies on prophages experimentally induced from these strains are limited. Herein, we screened inducible prophages from ruminant-derived SBSEC strains, including the newly reported S. ruminicola , leading to the characterization of a representative temperate phage. We successfully induced a temperate phage (vB_SbS-proRumen) from S. ruminicola KCCM 90354, which has a broad host range, capable of lysing several SBSEC strains and other lactic acid bacteria. The vB_SbS-proRumen belongs to the Siphovirus, characterized by a short latent period, high burst size, and stability across pH and temperature conditions typical of subacute ruminal acidosis. The phage also demonstrates potent anti-biofilm activity. The vB_SbS-proRumen has a 38,092 bp double-stranded DNA genome with 58 predicted open reading frames, sharing high similarity and conserved genetic organization with other previously predicted SBSEC prophages. This study provides valuable insights into the diversity and plasticity of SBSEC phages.
Dapagliflozin attenuates cisplatin-induced nephrotoxicity in rats through modulation of ROS/NF-κB, BCL2/Bax and PINK1/Parkin signaling pathways
Abstract Dapagliflozin (DPG), an anti-diabetic drug, has gained attention for its renal protective effects through multiple molecular pathways, yet its impact on mitophagy in cisplatin (CIS) nephrotoxicity remains unclear. This study aimed to examine the impact of DPG against CIS-induced nephrotoxicity in rats, targeting mainly PINK1/Parkin-mediated mitophagy and inflammatory/apoptotic pathways. Male Sprague Dawley rats received DPG (10 mg/kg; p.o) daily for 14 consecutive days and AKI was induced by a single injection of CIS (7 mg/kg; i.p) on day 10. Blood glucose, serum levels of creatinine and urea nitrogen, oxidative stress, inflammatory, apoptotic, mitophagy markers, and histological changes were assessed. DPG reduced glomerular and tubular damage by alleviating NGAL and KIM-1 protein expression as well as MDA and NO accompanied by enhanced GSH expression. It mitigated gene expression of NF-κB, TNF-α and IL-6 along with downregulation of Bax and upregulation of BCL2 mRNA expression. DPG prevented apoptotic activity through reduction in cleaved caspase-3 immunoreactivity. Moreover, DPG restored CIS-mediated mitophagy inhibition evidenced by elevation of PINK1, Parkin and LC3II/LC3I ratio and reduction of TIMM23, TOMM20 and p62. In conclusion, DPG prevents CIS nephrotoxicity probably, via activating PINK1/Parkin, meanwhile attenuating oxidative stress and apoptotic activity.
Computational solutions for fractional-order modeling of Visceral Leishmaniasis using Caputo derivatives
A synergistic framework integrating CPO-VMD with BiLSTM-TimesNet for accurate prediction of nonlinear and nonstationary runoff time series
Gap-graded soil erosion modes predicted by µ-CT informed graded erosion model and multi-criteria assessment
Customer churn prediction in privacy-preserving HashCode-based security abstractions
Comparative assessment of five analytical methods for airborne microplastics highlights importance of identifying sub-$$10~\upmu \hbox {m}$$ methods
Integrative study of two invasive North American pine aphids (Cinara atlantica and C. watsoni) in South Korea
Abstract This study investigates the seasonal ecology, morphology, and invasion history of the aphids Cinara atlantica and C. watsoni (Hemiptera: Aphididae: Lachninae) in South Korea and assesses their potential ecological impacts. Historically, C. atlantica was recorded only on non-native pines, but we provide the first evidence of host expansion to the native pine Pinus densiflora . C. watsoni is recorded for the first time in South Korea on imported pines, indicating a potential risk of spread to native hosts. Field surveys conducted between 2020 and 2025, including monthly monitoring, showed that both species reproduce anholocyclically, with colony densities peaking in June and October–November. Honeydew accumulation promoted sooty mold development, and heavy infestations caused needle yellowing. Morphological redescriptions, DNA barcoding, and haplotype analyses confirmed species identities and revealed minimal genetic divergence between South Korean and Nearctic populations. Shared haplotypes with North American material suggest a recent introduction possibly mediated by international plant trade, although the precise source remains uncertain. These findings highlight the high invasion potential of Cinara species and emphasize the need for strengthened phytosanitary measures and continuous monitoring of conifer-associated aphids in East Asia.