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In-silico study of the bioactive compounds of Blighia sapida koenig revealed a novel Plasmodium falciparum dihydroorotate dehydrogenase inhibitor for malaria
An integrated controller-estimator technique for vector control and speed estimation in PMSM drive
Bridge technique self-traction improves outcomes over conventional endoscopic submucosal dissection for semicircumferential gastric cardia neoplasms in a randomized controlled trial
Predictive analysis on mechanical properties, material flow and thermal analysis of friction stir welded dissimilar AA2014/AA7075 Al-alloy joints using machine learning
Maritime obstacle-aware formation control for USVs with an optimized artificial potential field
Acute physiological and perceptual responses in the FIT FIRST FOR ALL school-based physical activity program
Abstract This study examined acute physiological and perceptual responses to the FIT FIRST FOR ALL program, a structured school-based physical activity intervention designed to promote engagement. In a non-randomized cluster study conducted in the Faroe Islands, 179 pupils aged 7–16 participated in three weekly 40-minute sessions for 10 weeks as part of a school-wide program alongside physical education. Acute responses were assessed in a subsample ( n = 53) using heart rate, accelerations, perceived exertion, and enjoyment, with individualized thresholds and stratification based on baseline cardiorespiratory fitness assessed using a shuttle run test. Sessions consistently elicited moderate-to-vigorous intensity, with mean heart rate ranging from 67.2 ± 1.3 to 69.9 ± 1.4% of maximal heart rate. Pupils spent 57.9 ± 3.6 to 64.9 ± 3.3% of session time at moderate-to-vigorous intensity, including up to 31.8 ± 3.0% at vigorous intensity. Despite higher physiological and perceived exertion among pupils in the low fitness group, enjoyment was comparable across fitness groups. Cardiorespiratory fitness improved among the intervention sample ( n = 117), with a tendency for greater gains in the lowest fitness tertile, although differences were not statistically significant ( p = 0.063, ε² = 0.024). These findings suggest that FIT FIRST FOR ALL can elicit health-promoting intensity and high enjoyment across age and fitness groups when delivered school-wide through teacher-led sessions.
Theoretical analysis of low power synergistic sono-optogenetic control of calcium-dependent synaptic plasticity
Theoretical–experimental study of new synthesized hydrazine–hydrazone benzenesulfonamide inhibitors for carbon steel in a 1.0 M HCI DFT, QSAR
Abstract In this study, quantitative structure-activity relationship (QSAR) modeling using genetic function approximation was applied to predict the corrosion inhibition efficiency of three synthesized hydrazone derivatives, IHE, BHE, and AHE, on N80 carbon steel in 1.0 M HCl solution at various concentrations (50–400 ppm) and temperatures (298–358 K). The inhibitors’ performance was evaluated via electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP), weight loss (WL), and surface analysis techniques. Corrosion inhibition increased with concentration, reaching maximum efficiencies of 90.34% (IHE), 85.93% (BHE), and 67.97% (AHE) at 400 ppm. Adsorption followed the Langmuir isotherm, indicating monolayer formation. High adsorption equilibrium constants (K ads ) and negative free energy changes ( $$\:{{\Delta\:}\text{G}}_{\text{a}\text{d}\text{s}}^{\text{o}}$$ : − 36.00, − 32.78, − 30.05 kJ/mol) confirmed strong, spontaneous adsorption of the inhibitors onto the steel surface. Density functional theory (DFT) and molecular simulations further revealed favorable electronic properties and stable adsorption behavior, supporting the experimental results. The combined theoretical and experimental data highlight the efficiency of the hydrazone derivatives as promising corrosion inhibitors for carbon steel in acidic environments.
Ethnicity-specific molecular subtypes and a machine-learning risk model in Asian patients with non-muscle-invasive bladder cancer
Author Correction: Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors
Gold nanoparticles exhibit anticancer property through induction of oxidative stress and autophagy in MCF-7 breast cancer cells
Large-scale analysis of temporal gene expression variation in peripheral blood
Abstract Transcriptomic profiling of peripheral blood offers a promising, non-invasive approach for disease diagnosis and monitoring. However, its clinical translation is hindered by limited knowledge of the natural temporal variation. Here, we present a comprehensive reference map of longitudinal transcriptomic variability, based on RNA-sequencing of 333 healthy individuals sampled at three time points over six months. We find that 85% of genes and 99% of transcripts exhibit greater intra-individual than inter-individual variation, primarily driven by dynamic regulation of housekeeping pathways. In contrast, immune-related transcripts –particularly those linked to T and B cell activity– are strikingly stable over time. Gene expression levels drive inter-individual differences, while splicing variation contributes more to intra-individual fluctuation. In an independent twin cohort (148 monozygotic, 166 dizygotic), genes with high inter-individual variability show greater heritability, suggesting genetic control of steady-state expression. By integrating extensive clinical and environmental data, we trace temporal expression changes to genetic, compositional, and external factors, and identify robust seasonal and sex-specific signatures. These findings were validated in a third, cross-sectional cohort of 3,480 individuals. The observed temporal variation patterns have important implications for cohort-based transcriptomic analyses, as they may limit discovery and reproducibility of expression quantitative trait loci and increase the risk of spurious associations in cross-sectional studies. This resource provides a critical baseline for distinguishing disease-associated transcriptomic changes from normal physiological variation, advancing the reliability of blood-based biomarkers in clinical practice.
Discrepancies in reporting lifestyle and dietary habits by children and parents and their association with anthropometric parameters in 10–12-year-old Polish students: a cross-sectional study
Impact of air-ice CO2 fluxes on polar ocean carbon budgets from a bipolar data compilation
A hybrid transformer-PPO framework for multi-objective energy management in renewable-based microgrids
Mechanochemical Single-Carbon Insertion into (Iso)quinolines
Strain-engineered Ge-source double-gate TFET with Si/SiGe/Si channel for low-power and THz frequency applications
High-quality NiOx nanoparticles synthesized via low temperature chemical precipitation method for high-performance inverted perovskite photovoltaics
Hybrid immunity following SARS-CoV-2 infection and vaccination is associated with more sustained antibody levels, and lower reinfection risk
Abstract A decline in antibody levels against SARS-CoV-2 over time is expected and may lead to breakthrough infections (BTI; infection occurring after vaccination) and reinfections (infection occurring after recovery from a prior SARS-CoV-2 infection). This 12-month longitudinal study investigated the effects of antibody kinetics following SARS-CoV-2 vaccination and infection on the timing and likelihood of BTI or reinfection. Serum IgM, IgA, IgG, and neutralizing antibodies (NAb) against the ancestral SARS-CoV-2 variant were measured in a prospective cohort of 267 participants in Malaysia from March 2021 to May 2023, stratified by the order and timing of SARS-CoV-2 infection and vaccination relative to study enrollment. IgG levels following SARS-CoV-2 infection in individuals previously vaccinated with CoronaVac were higher up to Day 60 compared with those who received BNT162b2 or ChAdOX1 as their primary vaccination; however, antibody levels across vaccine platforms were not statistically different at six months and beyond post-vaccination. The risk of BTI was similar across vaccine platforms, whereas individuals with a history of SARS-CoV-2 infection prior to vaccination showed the lowest subsequent reinfection risk. Breakthrough infections in vaccinated individuals were associated with more sustained IgA, IgG, and NAb levels compared with vaccinated individuals without infection. Our results demonstrate that exposure sequence, rather than vaccine platform alone, is a key determinant of long-term antibody durability and reinfection risk, providing clinically interpretable evidence to inform vaccination strategies in the endemic phase of SARS-CoV-2.