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STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS OF ZIDOVUDINE AND LAMIVUDINE FROM THEIR COMBINATION DRUG PRODUCT

A simple and precise chromatographic stability indicating reverse phased HPLC method for estimation zidovudine (ZDV) and lamivudine (LMV) from their combination product has been developed and validated using different validation parameters. In the developed RP HPLC method, YMC, Pack ODS A, (250 mm X 4.6 mm), 5 μm column is used. The mobile phase consisting of Acetate Buffer pH 4.0 and methanol in the proportion of 80:20 (v/v). The detection was done using photodiode array detector at 270 nm. The combination drug product of ZDV and LMV was exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were analysed by the designed method. The data of peak homogeneity in stressed sample chromatograms of ZDV and LMV peaks, illustrated the specificity of the method for their estimation in presence of degradants. The described method was linear over a range of 0.025 ppm to 0.75 ppm for Zidovudine and 0.05 ppmto 1.50 ppm for lamivudine. The mean recoveries were 101.24and 97.63% for Zidovudine and Lamivudine, respectively.

HERD IMMUNITY AND COVID-19 VACCINES: AN OVERVIEW

COVID-19 is a very contagious disease. Vaccines are essential tool to protect from COVID-19 virus Therefore; a vaccine will make a critical addition to immunity system against COVID-19. The World Health Organization estimates that 65 to 70 percent of a given population must be vaccinated to halt the spread of COVID-19 virus. Natural immunity occurs when people become immune to a specific disease after contracting it so immune system makes the antibodies against the germ causing the infection. However, herd immunity occurs when a sufficient percentage of a population is immune to an infectious disease through vaccination or prior illness that it stops the spreading of disease. Currently, social distancing, wearing mask and frequent hand washing are tools that help to prevent the spreading of COVID-19 virus. Here, we review the available COVID-19 vaccines, herd immunity and vaccination towards the safe immunization of the world’s population against COVID-19 virus.

FREE DRUG DISTRIBUTION IN RAJASTHAN

Rajasthan Mukhyamantri  Nishulk Dava Yojana was launched on 2nd October 2011, by the Chief Minister of Rajasthan Shri Ashok Gehlot. Formally called the Mukhyamantri Nishulk Dava Yojana (MNDY), the Chief Minister’s Free Medicine Scheme, this Scheme provides quality, generic drugs at no expense to all and helps to ease the significant out of pocket expenditures on health care that the current national health system demands. The Rajasthan Medical Services Corporation (RMSC) was created and given the responsibility for centralized purchasing, quality control and providing medicines to all health facilities in the state.  The Rajasthan government ensured that people get free medicines for 104 serious diseases. In this review, we have seen how free drug distribution is done in Rajasthan and how it is handled and how this system is going to be done in the future.

AUTONOMOUS VEHICLE OF WEEDING ROBOT FOR MORE ECOLOGICAL AND ECONOMICAL WEEDING

Agricultural productivity is something on which our economy highly depends. This is the one of the reasons that disease detection in plants plays an important role in agriculture field. Insect pests are dangerous for the overall growth of the crops. Several Integrated Pest Management strategies have been tailored for the effective management of insect pests under filed condition. But, a prime method to protect the crop may be the regular monitoring of the crop for the occurrence of the insect pests to understand the health of the crop. Early detection of insect pest infestation to evolve suitable management techniques, therefore, would be an important step towards successful implementation of pest control strategies at appropriate time targeting the most vulnerable stage of the insect pest. Further, if the insect pests are detected at their early stage, appropriate measures can be taken to protect the crop from future damage that can be caused by the insect thereby immense crop loss can be minimized. This paper presents an algorithm for image segmentation technique which is used for automatic detection and classification of plant leaf diseases. It also covers survey on different diseases classification techniques that can be used for plant leaf disease detection. The diagnosis of plant disease by computer vision using image processing methodology is a key for timely intervention and treatment of healthy agricultural procedure and to increase the yield by natural means. Digital image processing has three basic steps: processing, analysis and understanding. Image processing contains the pre-processing of the plant leaf as segmentation, color extraction, diseases specific data extraction and filtration of images. Image analysis generally deals with the classification of diseases

MODEL IDENTIFICATION CONTROL FOR REFINERY PROCESS

Study of refinery process model identification

INTEGRATED WATER RESOURCE MANAGEMENT FOR KOVILPATTI – A FUTURISTIC APPROACH

Today, sustainable utilisation of water is becoming more complicated due to dwindling water resources. Hence water is so important but now a day there is insufficiency and scarcity of water in some places. Hence to solve the problem we need to conserve water. Water conservation includes all the policies, strategies and activities to sustainably manage the natural resource of fresh water, to protect the hydrosphere and to meet the current and future human demand. This paper focuses on the study of the prevailing water scarcity and demands in the southern part of Tamil Nadu, India by analysis the existing water resources available , population , quality of water and the quantity of water . Finally this paper makes appropriate suggestions to establish sustainable water management without compromising the quality of water. Population, household size, growth and affluence all affect how much water is used. Factors such as climate change have increased pressures on natural water resources especially in manufacturing and agricultural irrigation. Water resource management is the activity of planning, developing, distributing and managing the optimum use of water resources. The field of water resources management will have to continue to adapt to the current and future issues facing the allocation of water. With the growing uncertainties of global climate change and the long term impacts of management actions, the decision-making will be even more difficult. As a result, IWRM would be a better solution with alternative management strategies are sought for in order to avoid setbacks in the allocation of water resources. In this work, we are trying to implement our IWRM technique in our region. Ideally, water resource management planning regard to all the competing demands for water and seeks to allocate water on an equitable basis to satisfy all uses and demands. Integrated Water Resource Management (IWRM) will create a pavement for solving the water scarcity by means of managing water resources. By collecting all water supply data in a particular region (kovilpatti) and we came to know that all 36 wards of kovilpatti town are safe from scarcity but it is known that the scarcity was faced by the kovilpatti panchayat people, Our solution for that people is by treating the water from natural tanks and thus IWRM is performed in kovilpatti region. The characteristic study is performed for these natural tanks.

ANDROID BASED COLLEGE APPLICATION FOR STUDENTS

OPTIMIZATION OF ETHYLENE PLANT FRACTIONATION PROCESS

Research and Study of Ethylene Plant Fractionation Process

ANALYSIS OF OPERATION PERFORMANCE AND MAINTENANCE OF IRRIGATION NETWORK IN NORTH MOROWALI DISTRICT

Tambayoli Irrigation Area (Provincial Authority) located in North Morowali Regency has an area of 1,210 hectares, functional area 904 hectares, the realization of planting area I (MT. I) = 622 Ha, Planting Period II (MT. II) = 634 Ha. The Mamosalato Irrigation Area (Regency Authority) is also located in North Morowali Regency which has an area of 374 Ha, 152 Ha Functional Area, the realization of planting area I (MT. I) = 90 Ha, Planting Period II (MT. II) = 123 Ha. The irrigation area in these 2 (two) locations utilizes river water flow as a source of water, but there are several Irrigation Areas which are irrigation areas that can be classified as technical irrigation networks because they have permanent tapping structures and structures for those who are able to regulate and measure water flow. In irrigated areas, irrigation network operations and maintenance are rarely carried out. Therefore, it is necessary to evaluate the operation performance and maintenance of irrigation networks to determine the extent of the irrigation system's performance. The purpose of this study is to determine the performance of the authority of the Province D.I irrigation OP. Tambayoli and D.I. Mamosalato. Methods of data analysis were carried out by means of surveys and direct interviews in the field. The results showed that based on the overall index assessment the performance of the D.I. irrigation system. Tambayoli is 71.31%, which means that the performance is good (70% - 79%) while the performance of the irrigation system is D.I. Mamosalato is 44.55%, which means poor performance and needs attention (<55%), this is because D.I. Mamosalato received very little attention from the local government and the central government.

ANALYSIS OF FACTORS AFFECTING THE IMPLEMENTATION OF THE PROGRAM SWADAYA HOUSING STIMULANT ASSISTANCE IN THE DISTRICT BANGGAI ISLANDS

Home as a basic human need. To increase welfare, housing needs must be met. The State should improve the welfare of its citizens to help low-income people meet their housing needs. One of the things that the Indonesian government has done is the establishment of the Self-Help Housing Stimulant Assistance Program (SHHS). The research objective is to determine the dominant factors affecting the mismatch in the implementation of the Technical Guidance for Self-Help Housing Stimulants in Banggai Islands Regency. The research location was conducted in the Banggai Islands Regency. The sampling technique was carried out by simple random sampling of 61 respondents who received Self-Help Housing Stimulants in 2019. The analysis method used is factor analysis. The results of the study obtained 4 new factors consisting of 10 variables that affect the mismatch in the implementation of the Technical Guidelines for Self-Help Housing Stimulant (SHHS) assistance in Banggai Islands Regency from 8 initial factors and 32 initial variables. These factors are the factor of completeness of the specifications of the house and area facilities which consists of 6 variables, the labor factor which consists of 2 variables, the human resource factor, and the material factor which each consists of 1 variable.

EDUCATION FOR LIBERATION: A NEED–BASED LEADERSHIP AND LEARNING

This study aims to analyze education for liberation; need-based leadership and learning in Qaryah Thayyibah Salatiga education. The research method that was used in this research was qualitative. The data source was the head of Qaryah Thayyibah Salatiga, a companion, and students. Data collection techniques were observation, interview, and document study. The data validity technique by using triangulation, the data analysis technique used the interactive model of Miles and Huberman. The results of the study are found that there is the exploration of potential as a basis for leadership participation and empowerment in Qaryah Thayyibah; the development and performance evaluation as the basis for leadership and learning in Qaryah Thayyibah. Conclusion: Leadership rests on exploring potential, developing, and evaluating performance. Suggestion, to the head of Qaryah Thayyibah Salatiga to keep the educational chain as the basis of learning by maintaining the principles that are owned both in learning and in management.

AN ANALYSIS TO EFFECT OF DISTANCE AND FLUORO-TIME ON THE WORKER DOSE IN CARDIOVASCULAR INTERVENTION TREATMENTS

This study aims to analyze the effect of distance and fluoro time on increasing workers radiation dose inside Cath Lab room. Also to analyze the differences results of TLD and Pocket dosimeter in determining workers radiation dose. There are 254 data is needed for statistical analysis, 206 data for analyzing the relation of distance and Fluoro-time against dose, and 276 data from Pocket dosimeter plus 6 data from TLD measurements for analysing the differences of dose on Pocket dosimeters and TLDs. From statistical analysis showed that each exposure factor had no effect on worker dose, but simultaneously exposure factor impacted to dose 14,9 % for Operator and 15,5% for Radiographer . In addition, long-time of fluoro-time does not relate to the dose. The trend shows a decreasing of dose along the Fluoro time axis for both distances. Meanwhile, Radiographer tends to receive dose more stable than Operators due to their distance from exposure area. Moreover, Dose recorded on TLD are consistently higher than on Pocket Dosimeter.

IMAGE RECONSTRUCTION ON COMPUTED TOMOGRAPHY USING PYTHON PROGRAMMING LANGUAGE

This study aims to create an image reconstruction program using the Python programming language from the synogram of scanning perfume bottles on a computed tomography system simulator. Sinogram data retrieval was obtained from the collection of perfume bottle scanning results. The synogram will then be reconstructed in Python to get the reconstructed image. The test was performed visually and numerically which included reconstruction speed, spatial resolution and signal to noise ratio (SNR). In the research that has been done, using Python an image reconstruction program can be made. This program can be used to reconstruct the results of the scanning process synograms on the Computed Tomography system simulator so that an image is generated. The image quality reconstructed using Python is better than the reconstructed image quality using Matlab. However, judging from the time required for the reconstruction process, the reconstruction process using Python requires a longer time than the reconstruction process using Matlab.

ROLE OF MACHINE LEARNING AND DEEP LEARNING APPROACH FOR HUMAN DISEASES

Insights and software engineering, for instance, are required for the wellbeing related piece of looking since this acknowledgment is frequently troublesome. These fields need to stretch out from their ordinary practices and take on new methodologies. Since there are so many novel methodologies, a rundown can be given without meticulously describing every single one of them. We recommend an exhaustive investigation of human circumstances related with machine learning to accomplish this objective. In this examination, well known machine learning techniques are dissected. Foreseeing the course of a sickness at the hour of determination depends vigorously on the capacity to perceive designs. Our frameworks should have the option to gain from recently diagnosed diseases and be sufficiently adaptable to oblige novel procedures, subsequently we want a sickness expectation framework that can precisely recognize the condition by examining a few boundaries/side effects. To help the clinical local area in their assessment of patient disorders, a graphical client union will be improved. The graphical UI is intended for usability by clinical experts

SYNTHESIS AND EVALUATION OF ANTIFUNGAL ACTIVITY OF 4, 6-DIPHENYL-3, 4- DIHYDROPYRIMIDINE-2-(1H)-ONE DERIVATIVES

In the present work was designed to synthesize and evaluate the antifungal activity of    4, 6-diphenyl-3, 4- dihydropyrimidine-2-(1H)-one derivatives. The 3, 4- dihydropyrimidin 2 (1H)-one was used as nucleus for the synthesis of N-mannich bases of pyrimidine derivatives. All synthesized intermediates and products were identified on the basis of melting point range, Rf value, Elemental analysis, and IR spectral analysis. The synthesized compounds were screened for their antifungal activity against Candida albicans (MTCC 227) and Aspergillus niger (MTCC 282) in Sabouraud’s dextrose agar medium using fluconazole as a standard drug.

TARGETING NOVEL APPROACH OF CORONAVIRUS -2019: BROAD VIEW IN PREDICTION OF POSSIBLE POTENTIAL DRUGS ETIOLOGY, INFLAMMATION INDICATORS OF SARS-COV-2

Currently the world is facing the pandemic crisis due to COVID-19 (SARS-CoV-2).since the mutation of the spike protein in this virus occurs frequently; the pharmacy as well as biotech sector is facing lot of issues in the invention of its treatment. This study works on the finding of potential drug through broad view in the broad spectrum antiviral agents as well as in the various virus groups preferably those causing respiratory and gastric ailments.

WOODEN MASK MAKING TECHNIQUES WITH 3 AXIS CNC ROUTER MACHINE

This study aims to determine the technique of making wooden masks with a 3-axis CNC Router machine and to compare the time and quality of the results of making masks manually. This research method uses cangkring wood, mahoni wood and pule wood. The design process with the help of the CorelDraw software, Aspire vectric. Manufacturing process with the mach-3 software. The machining process of a 3 Axis CNC Router with a variety of machining roughing and finishing with a variety of tool paths, step over, step down, spindle rotation, plugrate, feederate, and machining time. The results showed making wooden masks with a CNC Router machine has a faster time, uniform shape and size than manual making. Pule wood material provides a faster yield, smoother surface, and machineable than cangkring wood and mahoni wood. The machining time of the CNC router for making one wooden mask is 2 hours-20 minutes for cangkring wood, 3 hours-06 minutes for mahogany wood, and 2 hours-07 minutes for pule wood.

THE USE OF RADON TRANSFORMATION AS A SARONG MOTIF

In this paper I will present the use of Radon transformation to design sarong motifs. The sarong is a large piece of cloth sewn at both ends to form a tube. Sarongs are made of a variety of materials: cotton, polyester, or silk. There are various kinds of sarong motifs, namely geometric, non geometric and a combination of geometric and non geometric. The concept of Radon transformation has spread across all fields of science, medicine and geophysics. This paper aims to provide an algorithm for making non-geometric patterns that can be used as sarong motifs. Algorithm consists of base, transformation and coloring. To help readers better understand the algorithm, I will present a computer program using Matlab. I describe an algorithm based on the Radon transformation that can fill a spatial region based on the Radon transformation of a base image with a random sampling area. With this algorithm, we can generate thousands of beautiful variations of patterns, of which I will show some examples.

AWS SERVERLESS MESSAGING USING SQS

In the dynamic and rapidly evolving realm of cloud computing, messaging stands as a pivotal element in constructing resilient and high-performing serverless applications. AWS offers a range of services facilitating seamless communication among various application components, including AWS Lambda, Simple Queue Service (SQS), and event-driven architectures. Within this detailed guide, we will delve into the diverse facets of messaging within AWS serverless environments, showcasing its capacity to empower developers in crafting scalable and robust applications.

APPLICATION OF THREADS

The motive behind the selection of this topic is the wide range of application and usage of threads in today’s technology. It’s become essential to cut back the time for execution of various processes. So, developing solutions to problems using threads helps us solve multiple tasks in a very time economical manner. To accomplish this, a deep understanding of the concept of multi-threading is crucial. Our motive is to get thorough knowledge concerning this concept to enable us to use this concept ourselves towards a real-life problem. We will be using this concept to solve the subsequent problem: A man needs to cross a river. He possesses a tiger, a goat and a basket containing grass. There is a ship on the river. The utmost capacity of the boat is to hold two entities at a time. The man has to cross the river with his tiger, goat and basket of grass. If he goes with the basket at the opposite side of the river the tiger can eat the goat, if he takes the tiger with him to the opposite side then the goat can eat the grass from the basket. Here processes require resources which can be made available once the other process gets completed, these condition results in deadlock. The problem is how to design a discipline of behaviour (a concurrent algorithm) to seek out the sequence of the four will cross the stream safely.