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YouTube as an information source in deep margin elevation: Reliability, accuracy and quality analysis
The objective of this research was to assess the accuracy, quality, content, and demographics of videos on YouTube concerning deep margin elevation (DME). Initially, 100 videos for each of the three keywords were analyzed. The content categories of these videos were diverse, encompassing educational materials, teaching techniques, advertisements, and other types of content. The evaluation of the videos was carried out based on the Global Quality Scale (GQS), the Journal of the American Medical Association (JAMA) benchmark, and the modified-DISCERN questionnaire (m-DISCERN). Non-distributed data were analyzed using the Kruskal Wallis test and the Spearman correlation coefficient. The JAMA score was 1 for four videos, 2–3 for 38, and 4 for 14 videos; the GQS score was 1–2 for 18 videos, 3 for 11 videos, and 4–5 for 27 videos; and the m-DISCERN score was < 3 for 39 videos, 3 for four videos, and > 3 for 13 (for a total of 56 videos). Statistically significant differences were observed only for the JAMA scores when comparing the video source groups (p = 0.001). There were significant positive correlations between the GQS and m-DISCERN and m-DISCERN and JAMA scores (p < 0.001 and p = 0.049, respectively). The findings indicated that YouTube videos related to DME generally exhibited high-quality content but only moderate accuracy and poor reliability.
Metal oxides carbon xerogel nanocomposite for methanol oxidation fuel cell
Abstract The primary requirement for electrode materials in direct methanol fuel cells (DMFC) is efficient electrocatalyst that exhibit high tolerance to methanol oxidation, excellent stability, and reasonable cost. The combination of distinct active materials with distinctive architectures may facilitate the attainment of this objective. The present study included the preparation of a Carbon Xerogel Doped with various metal oxides derived from Banana peels. The nanocomposites were thoroughly examined utilizing several characterization modalities including XRD, FTIR, and SEM. The electrocatalytic performance of Carbon xerogel doped with Iron (Fe3O4/CX), carbon xerogel doped with magnesium (MgO/CX), and carbon xerogel doped with Copper (CuO/CX) about the Methanol Oxidation Reaction (MOR) was investigated using electrochemical methods such as cyclic voltammetry, impedance spectroscopy, and chronoamperometry. The results showed that the Fe3O4/CX, MgO/CX, and CuO/CX are effective electrocatalysts with an onset potential of around 1.00 V and current densities of approximately 42.98 mA cm − 2, 28.2784 mA.cm − 2, and 6.60698 mA.cm − 2, respectively, in the optimized electrolyte for methanol oxidation. The stability of Fe3O4/CX, MgO/CX, and CuO/CX electrodes was examined using chronoamperometry and the Cyclic Stability method. The results revealed that the (Fe3O4/CX) electrode exhibited outstanding stability throughout the whole 60-minute chronoamperometry Technique and demonstrated great stability for 100 cycles in the Cyclic Stability technique. The remarkable electrochemical activity and stability may be attributed to the synergistic effect of Fe3O4/CX, which provided sufficient active sites for methanol electro-oxidation and reduced the equivalent series resistance, as shown by the electrochemical impedance spectroscopy analysis. This work used environmentally friendly materials, which presents a novel opportunity to enhance the efficiency of methanol oxidation via the utilization of affordable catalysts. This study of the theoretical technique methods for establishing the route of methanol decomposition, and systematizes their confirmation with experimental data, within the methodological framework.
Optimized fertilization patterns increase foxtail millet biomass on the distribution and transformation in Loess Plateau of China
Organic manure or microbial fertilizers are essential sources of plant nutrients to supplement farmland soil, and organic and inorganic fertilizers are considered an effective way to achieve sustainable agriculture by improving the soil and increasing crop yields. This experimental material was used foxtail millet (Setaria italica) “Changsheng 07”and started in the growing season of 2017–2018 in a dry farming area of northern Shaanxi Province, with five different fertilizing patterns, and each four repetitions, including T1(N,45kg·hm-2),T2(N,60kg·hm-2; P2O5 30kg·hm-2),T3(N,90kg·hm-2;P2O5 45kg·hm-2),T4(N,60kg·hm-2;P2O5 40kg·hm-2,Organic matter 2000kg·hm-2),T5(N,60kg·hm-2;P2O5 40kg·hm-2; microbial fertilizer 5kg·hm-2). The results showed that: (1) the above-ground dry matter accumulation with T4 and T5 increased by 15.04% and 33.68% during the flowering and pustulation stages, and the root/shoot ratio of T4 increased by 9.32% and 12.46% over two experimental years, respectively. (2) the leaf water use efficiency (WUEL) of T4 increased by 15.61%, 0.51% in two stages, respectively, (3) the yields and water use efficiency (WUE) of T3 exhibited a significantly increased by 11.06% and 37.61%, 9.50% and 37.51%, and increased stably by 9.23%-35.17% and 8.73%-35.11% in T4 and T5 respectively, over two seasons. In summary, applying organic and inorganic manure could effectively regulate the accumulation and distribution of above-ground biomass of foxtail millet, and ensure the high and stable grain yield.
A comprehensive scoping review and meta-analysis of upper limb strength asymmetry
Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment
Glioblastoma (GBM) tumors exhibit extensive genomic, epigenomic, and transcriptional diversity, with significant intratumoral heterogeneity, complicating standard treatment approaches involving radiation (RT) and the DNA-alkylating agent temozolomide (TMZ). In this study, we employed an integrative multi-omics approach, including targeted proteomics, transcriptomics, genomics, and DNA methylation profiling, to investigate the response of a representative panel of GBM patient-derived cancer stem cells (CSCs) to astrocytic differentiation and RT and TMZ treatments. Differentiated CSC progenies retained the expression of key stemness genes and survival pathways, while activating the BMP-Smad signaling pathway and upregulating extracellular matrix components. This was associated with increased resistance to TMZ, though not to RT, across all models. We identified TP53 status as a critical determinant of transcriptional response to both RT and TMZ, which was also modulated by the differentiation state and treatment modality in wildtype (wt) p53 GBM cells. Both mutant and wt p53 models exhibited significant activation of the DNA-damage associated interferon (IFN) response in CSCs and differentiated cells, implicating this pathway in the GBM response to therapy. We observed that activation of NF-κB was positively correlated with the levels of O-6-methylguanine-DNA methyltransferase (MGMT) protein, a direct DNA repair enzyme leading to TMZ resistance, regardless of MGMT promoter methylation status, further supporting the clinical potential for inhibition of NF-kB signaling in GBM treatment. Our integrative analysis of the impact of GBM cell developmental states, in the context of genomic and molecular diversity of patient-derived models, provides valuable insights for pre-clinical studies aimed at optimizing treatment strategies.
In vivo regulation of the monocyte phenotype by Mycobacterium marinum and the ESX-1 type VII secretion system
Abstract Pathogenic mycobacteria require the conserved ESX-1 type VII secretion system to cause disease. In a murine Mycobacterium marinum infection model we previously demonstrated that infiltrating monocytes and neutrophils represent the major bacteria-harbouring cell populations in infected tissue. In the current study we use this model, in combination with scRNA sequencing, to assess the impact of M. marinum infection on the transcriptional profile of infiltrating Ly6C⁺MHCII⁺ monocytes in vivo. Our findings demonstrate that infection of infiltrating monocytes with M. marinum alters their cytokine expression profile, induces glycolytic metabolism, hypoxia-mediated signaling, nitric oxide synthesis, tissue remodeling, and suppresses responsiveness to IFNγ. We further show that the transcriptional response of bystander monocytes is influenced by ESX-1-dependent mechanisms, including a reduced responsiveness to IFNγ. These findings suggest that mycobacterial infection has pleiotropic effects on monocyte phenotype, with potential implications in bacterial growth restriction and granuloma formation.
Comparison of frailty instruments for predicting mortality and prolon ged hospitalization in acute coronary syndrome patients
Objective To evaluate the relative strengths of 3 frailty assessment instruments for predicting mortality and prolonged hospitalization in acute coronary syndrome patients. Design Prospective cohort study. Setting Acute cardiac care units in New Zealand. Participants 1174 patients >70 years of age hospitalized with an acute coronary syndrome. Interventions The Clinical Frailty Scale (CFS), Edmonton Frail Scale (EFS) and Fried Criteria (Fried), were completed during hospital admission following an acute coronary syndrome when the patient was clinically stable. Primary and secondary outcome measures All-cause mortality over the next ~5 years and hospitalization for >10 days in the next year determined from national administrative data. Results During median follow-up of 5.1 years there were 353 deaths. Harrell’s C-statistic for mortality for EFS was 0.663, Fried 0.648 and CFS 0.640 (p<0.001 for all). C-statistics for hospitalization >10 days (n = 267, 22%) were EFS 0.649, Fried 0.628, and CFS 0.584 (p<0.001 for all). Associations between increase in frailty scores and mortality were graded including in patients not classified as frail. The hazard ratio (HR) for mortality, adjusted for age and sex, for patients with an EFS score ≥9 (n = 197) compared to ≤2 (n = 331) was 5.0 (95% CI: 3.4–7.4). In models which included the Euroscore II or GRACE risk scores the EFS improved risk discrimination for both mortality and prolonged hospitalization more than the CFS and Fried. Conclusion In older patients assessed following an acute coronary syndrome the EFS discriminated the risk of all cause mortality and prolonged hospitalization better than the CFS and Fried tests, and improved risk discrimination when added to clinical risk scores.
Small fishing boat classification and recognition method based on GASF temporal graph coding and EMPViT model
Multi-dimensional perceptual recognition of tourist destination using deep learning model and geographic information system
Perceptual recognition of tourist destinations is vital in representing the destination image, supporting destination management decision-making, and promoting tourism recommendations. However, previous studies on tourist destination perception have limitations regarding accuracy and completeness related to research methods. This study addresses these limitations by proposing an efficient strategy to achieve precise perceptual recognition of tourist destinations while ensuring the integrity of user-generated content (UGC) data and the completeness of perception dimensions. We integrated various types of UGC data, including images, texts, and spatiotemporal information, to create a comprehensive UGC dataset. Then, we adopted the improved Inception V3 model, the bidirectional long short-term memory network (BiLSTM) model with multi-head attention, and geographic information system (GIS) technology to recognize basic tourist feature information from the UGC dataset, such as the content, sentiment, and spatiotemporal perceptual dimensions of the data, achieving a recognition accuracy of over 97%. Finally, a progressive dimension combination method was proposed to visualize and analyze multiple perceptions. An experimental case study demonstrated the strategy’s effectiveness, focusing on tourists’ perceptions of Datong, China. Experimental results show that the approach is feasible for studying tourist destination perception. Content perception, sentiment perception, and the perception of Datong’s spatial and temporal characteristics were recognized and analyzed efficiently. This study offers valuable guidance and a reference framework for selecting methods and technical routes in tourist destination perception.
Influence of Artocarpus hirsutus (AH) cellulose micro fiber, bamboo fiber in thermoplastic biocomposites
Abstract In this experiment Artocarpus hirsutus (AH) fiber was utilized as the filler material for bamboo fiber (NF)/polyethylene (PE) biocomposites. This was a waste to wealth approach by utilising biomaterial and also can reduce the use of PE plastics. The crystallinity index (Crl) of 45.1%, 56.4%, 67% was observed in AH, alkali treated (NaOH) and cellulose AH fiber respectively. The combination with 20 wt% NF/3 wt% cellulose AH filler observed better tensile and flexural strength. Agglomeration at 4, 5 wt% affects the flexural properties by lesser interfacial adhesion with filler/matrix phase, having properties reducing up to 20.3 MPa. Comparing to cellulose AH filler, both alkali treated and untreated AH filler combinations possess lesser flexural strength. The addition of natural fibers increases the tensile and flexural modulus property with better properties at 30 wt% NF/5 wt% cellulose AH filler combination. The Impact strength doesn’t observe high influence with filler incorporation. This AH fiber hasn’t been explored in detail for mechanical and hydrophilic properties with incorporation with PE matrix. This fabricated composite is suited for bioengineering applications.
Simulation of the electrolyte imbalance in vanadium redox flow batteries
The stack is the core component of large-scale flow battery system. Based on the leakage circuit, mass and energy conservation, electrochemicals reaction in porous electrode, and also the effect of electric field on vanadium ion cross permeation in membrane, a model of kilowatt vanadium flow battery stack was established. The electro chemical reaction parameters, ion concentration and temperature of each single cell in the stack were calculated respectively. The imbalance of vanadium ion concentration and the effects of current density and electrolyte temperature on the electrolyte imbalance in the stack were studied.
No closure of the linea alba cervicalis reduces complications in endoscopic thyroidectomy
The effect of SGLT2 inhibitor in patients with type 2 diabetes and atrial fibrillation
Background Sodium glucose cotransporter 2 (SGLT2) inhibitors improve clinical outcomes in several populations including type 2 diabetes (T2D), chronic renal insufficiency, and heart failure (HF). However, limited data exist on their effects on atrial fibrillation (AF). Methods We conducted a retrospective cohort study using the National Health Insurance Service database. A total of 4,771 patients with T2D and AF who were newly prescribed SGLT2 inhibitors or DPP4 inhibitors were selected and matched in a 1:2 ratio by propensity score with 37 confounding variables. We assessed the effect of SGLT2 inhibitors on the composite outcome of either HF hospitalization or death. Results Over a median follow-up of 31 months, patients on SGLT2 inhibitors were associated with a lower risk of hospitalizations for HF or mortality compared to those on DPP4 inhibitors (HR 0.61; 95% CI 0.44–0.85; P = 0.004). SGLT2 inhibitor use was also associated with a lower risk of mortality (HR 0.61; 95% CI 0.39–0.94; P = 0.025) and CV mortality (HR 0.43; 95% CI 0.21–0.86; P = 0.018), but not of MI (HR 1.22 [95% CI 0.72–2.09]; P = 0.461) or stroke (HR 1.00 [95% CI 0.75–1.33]; P = 0.980). The incidence of hospitalizations for HF, although statistically insignificant, tended to be lower in the SGLT2 inhibitor group (HR 0.63 [95% CI 0.39–1.02]; P = 0.062). Conclusion In a nationwide cohort of patients with T2D and AF, SGLT2 inhibitor was associated with a lower risk of mortality, which may suggest that SGLT2 inhibitors may be considered as the first-line antidiabetic medication in patients with T2D and AF.
Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin
Abstract This study explored the impact of hydrolyzed gelatin (HG) concentration on the retention and therapeutic efficacy of human iPS cell-derived cardiomyocytes (hiPSC-CMs) when injected into the myocardium. The solubility of HG allows precise control over its concentration, influencing the distribution and leakage of injected solutions, which may affect therapeutic outcomes. Using both ex vivo and in vivo rat models, we investigated how varying HG concentrations affect the retention of solution and diffusion within the myocardium. In ex vivo static rat hearts, 10% HG minimized leakage but allowed significant diffusion. However, in pulsating in vivo hearts, 20% HG provided the best retention. In a rat myocardial infarction model, hiPSC-CMs suspended in 20% HG resulted in the highest cell retention. Echocardiogram showed a significant increase in the ejection fraction two weeks after transplantation compared to before transplantation. Additionally, cardiac magnetic resonance imaging (MRI) revealed that the ejection fraction was significantly higher than that of the sham group four weeks after transplantation. These findings suggest that optimizing HG concentration is crucial for enhancing the retention and therapeutic efficacy of hiPSC-CM transplants in treating heart disease.
Bruxism repercussions in muscular activation: Ultrasound differences in abdominal wall between women with and without bruxism. A cross-sectional study
Introduction Bruxism, often triggered by stress, induces temporomandibular alterations, increasing muscle activity and affecting dental occlusion. Prevalence of musculoskeletal conditions related to stress is higher in women, with craneo-cervical affectation being frequently reported. Moreover, some authors explore the relationship between temporomandibular disorders and postural alteration, affecting the trunk complex. This study aims to evaluate differences in abdominal muscle morphology between women with and without bruxism in Spain, and, secondarily, the effects of voluntary teeth grinding in abdominal muscle activation. Methodology An observational analytical cross-sectional study was conducted with 44 Spanish women (diagnosed with bruxism = 22, non-bruxism = 22). To ensure and corroborate the absence of bruxism from the control group, the Clinical Based Assesment questionnaire was used. Ultrasound measures of Transverse Abdominal, External Oblique and Internal oblique were recorded during rest and voluntary grinding. Results Grinding was associated with changes in abdominal muscle thickness in both groups, with statistically significant higher thickness values for all studied muscles. Moreover, the Bruxism group showed statistically significant higher values for all muscles in grinding conditions compared to the Non-Bruxism group. Significant differences in left transverse abdominal thickness were found between groups in resting condition. Further analysis using linear regression indicated that both Bruxism (t = -2.03, p = 0.049) and BMI (t = 3.13, p = 0.003) were significantly associated with muscle thickness, with BMI acting as a confounding factor. Age was not a significant predictor (p = 0.506), suggesting its limited role in this context. Conclusion The results of this study support the existence of an association between bruxism and the abdominal wall muscles structure and activation. This emphasizes the importance of considering bruxism in the evaluation of abdominal muscle function.
Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial
Expression of Concern: Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture
Older adults do not consistently overestimate their action opportunities across different settings
Abstract Am I still able to climb the ladder? Aging accompanies changes in physical constitution and a higher risk of injuries. At the same time, the judgment of action opportunities needs to be highly adaptive to the given task setting. We examined older adults’ (n = 40) judgment tendencies in four different tasks by use of a detection theory approach. The tasks’ setting differed in their boundaries’ proximity to the actor with either proximal (e.g., judging one’s hand fit into an opening) or distal boundaries (e.g., judging the reachability of a distant object). The older participants showed significantly more liberal judgments in tasks with distal boundaries. Body awareness and alertness were associated with the extent of judgment disparity between setting types. Subsequently, we compared a gender- and education-matched subsample of the group (n = 24) to a younger sample (n = 24). Older participants’ judgment tendencies were significantly more extreme, with stronger under- or overestimations depending on the type of setting. We discuss potential links between more extreme judgments in older adults and higher reliance on learned patterns. Future research is needed to further unravel these setting-dependent behavioral differences and the factors contributing to more extreme judgment tendencies with growing age.