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Bis-Cycloruthenated Complexes in Visible Light-Induced C–H Alkylation with Epoxides

CPT1A ameliorates microglia-induced neuroinflammation via facilitating VDR succinylation

Clinical value of predicting relapse within 3 months in alcohol-dependent patients using fNIRS in verbal fluency task

Investigation of quantum trajectories in photosynthetic light harvesting through a quantum stochastic approach

Adolescent Cerebellar Nuclei Manipulation Alters Reversal Learning and Perineuronal Net Intensity Independently in Male and Female Mice

The cerebellum, identified to be active during cognitive and social behavior, has multisynaptic connections through the cerebellar nuclei (CN) and thalamus to cortical regions, yet formation and modulation of these pathways are not fully understood. Perineuronal nets (PNNs) respond to changes in local cellular activity and emerge during development. PNNs are implicated in learning and neurodevelopmental disorders, but their role in the CN during development is unknown. Connectivity deficits, specifically between lateral CN (LCN) and cortical regions have been found in autism spectrum disorder with patients displaying reduced cognitive flexibility. To examine the role of LCN on cognition, neural activity was perturbed in both male and female mice using designer receptors exclusively activated by designer drugs (DREADDs) from postnatal day 21 to 35. We found that while an adolescent LCN disruption did not alter task acquisition, correct choice reversal performance was dependent on DREADD manipulation and sex. Inhibitory DREADDs improved reversal learning in males (5 d faster to criteria), and excitatory DREADDs improved female reversal learning (10 d faster to criteria) compared with controls. Interestingly, the DREADD manipulation in females regardless of direction reduced PNN intensity, whereas in males, only the inhibitory DREADDs reduced PNNs. This suggests a chronic adolescent LCN manipulation may have sex-specific compensatory changes in PNN structure and LCN output to improve reversal learning. This study provides new evidence for LCN in nonmotor functions and sex-dependent differences in behavior and CN plasticity.

Medical perspective on the systemic challenges involving indirect disaster-related deaths in Japan

Accuracy of capillary blood sampling for diagnosing syphilis infection

Multiple model visual feature embedding and selection method for an efficient ocular disease classification

Analysis of farmers’ perceptions on sustainable sweet orange farming in nigeria amid climate change

Microwave tomography for Lunar Penetrating Radar data processing in Chang’e 4 mission

Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging

An empirical analysis on webservice antipattern prediction in different variants of machine learning perspective

Deciphering the Role of Vinylene Carbonate in Shaping CO₂ Cluster Growth and Stability via Wavelet-Enhanced Microwave Spectroscopy

Evaluating the impact of built environment on shared electric bicycle connectivity in kunming’s public transport system

Stability Frontiers in the <i>AM</i>₆<i>X</i>₆ Kagome Metals: The <i>Ln</i>Nb₆Sn₆ (<i>Ln</i>:Ce–Lu,Y) Family and Density-Wave Transition in LuNb₆Sn₆

A machine learning-based investigation of integrin expression patterns in cancer and metastasis

Internalized oppression and deaf people’s mental health

Binary Phase Diagrams of Coordination Polymers with Eutectic Behaviors

Comprehensive analysis of LRRC42 as a potential biomarker and key cellular processes in cancer development

Entropy-Tailored Fast-Charging Sodium Layered Cathodes