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Widespread occurrence and relevance of phosphate storage in foraminifera

Nature Nicolaas Glock, Julien Richirt, Christian Woehle et al. Feb 27, 2025 DOI: 10.1038/s41586-024-08431-8

Abstract Foraminifera are ubiquitous marine protists that intracellularly accumulate phosphate1, an important macronutrient in marine ecosystems and in fertilizer potentially leaked into the ocean. Intracellular phosphate concentrations can be 100–1,000 times higher than in the surrounding water1. Here we show that phosphate storage in foraminifera is widespread, from tidal flats to the deep sea. The total amount of intracellular phosphate stored in the benthic foraminifer Ammonia confertitesta in the Wadden Sea during a bloom is as high as around 5% of the annual consumption of phosphorus (P) fertilizer in Germany. Budget calculations for the Southern North Sea and the Peruvian Oxygen Minimum Zone indicate that benthic foraminifera may buffer riverine P runoff for approximately 37 days at the Southern North Sea and for about 21 days at the Peruvian margin. This indicates that these organisms are probably relevant for marine P cycling—they potentially buffer anthropogenic eutrophication in coastal environments. Phosphate is stored as polyphosphate in cell organelles that are potentially acidocalcisomes. Their metabolic functions can range from regulation of osmotic pressure and intracellular pH to calcium and energy storage. In addition, storage of energetic P compounds, such as creatine phosphate and polyphosphate, is probably an adaptation of foraminifera to O2 depletion.

Tropical forest’s last old growth is being toppled — illegally

Nature Feb 27, 2025 DOI: 10.1038/d41586-025-00506-4

Superkiller complex problems expose a cancer-cell vulnerability

Nature Christopher U. T. Hellen, Tatyana V. Pestova Feb 27, 2025 DOI: 10.1038/d41586-025-00086-3

Rare genetic disorder treated in womb for the first time

Nature Smriti Mallapaty Feb 27, 2025 DOI: 10.1038/d41586-025-00534-0

Author Correction: Virus-induced senescence is a driver and therapeutic target in COVID-19

Nature Soyoung Lee, Yong Yu, Jakob Trimpert et al. Feb 27, 2025 DOI: 10.1038/s41586-025-08718-4

Trump’s siege of science: how the first 30 days unfolded and what’s next

Nature Jeff Tollefson, Max Kozlov, Alexandra Witze et al. Feb 27, 2025 DOI: 10.1038/d41586-025-00525-1

Ensemble reactivations during brief rest drive fast learning of sequences

Nature Sandon Griffin, Preeya Khanna, Hoseok Choi et al. Feb 27, 2025 DOI: 10.1038/s41586-024-08414-9

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order

Nature Max Kozlov Feb 27, 2025 DOI: 10.1038/d41586-025-00540-2

Modulated ringdown comb interferometry for sensing of highly complex gases

Nature Qizhong Liang, Apoorva Bisht, Andrew Scheck et al. Feb 27, 2025 DOI: 10.1038/s41586-024-08534-2

Newfound bat virus that uses notorious receptor poses ‘spillover’ risk

Nature Feb 27, 2025 DOI: 10.1038/d41586-025-00503-7

Author Correction: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases

Nature Feng Lan, Jizhou Li, Wenxuan Miao et al. Feb 27, 2025 DOI: 10.1038/s41586-025-08712-w

Ancient DNA reveals reproductive barrier despite shared Avar-period culture

Nature Ke Wang, Bendeguz Tobias, Doris Pany-Kucera et al. Feb 27, 2025 DOI: 10.1038/s41586-024-08418-5

Abstract After a long-distance migration, Avars with Eastern Asian ancestry arrived in Eastern Central Europe in 567 to 568 ce and encountered groups with very different European ancestry1,2. We used ancient genome-wide data of 722 individuals and fine-grained interdisciplinary analysis of large seventh- to eighth-century ce neighbouring cemeteries south of Vienna (Austria) to address the centuries-long impact of this encounter1,2. We found that even 200 years after immigration, the ancestry at one site (Leobersdorf) remained dominantly East Asian-like, whereas the other site (Mödling) shows local, European-like ancestry. These two nearby sites show little biological relatedness, despite sharing a distinctive late-Avar culture3,4. We reconstructed six-generation pedigrees at both sites including up to 450 closely related individuals, allowing per-generation demographic profiling of the communities. Despite different ancestry, these pedigrees together with large networks of distant relatedness show absence of consanguinity, patrilineal pattern with female exogamy, multiple reproductive partnerships (for example, levirate) and direct correlation of biological connectivity with archaeological markers of social status. The generation-long genetic barrier was maintained by systematically choosing partners with similar ancestry from other sites in the Avar realm. Leobersdorf had more biological connections with the Avar heartlands than with Mödling, which is instead linked to another site from the Vienna Basin with European-like ancestry. Mobility between sites was mostly due to female exogamy pointing to different marriage networks as the main driver of the maintenance of the genetic barrier.

Perovskite heteroepitaxy for high-efficiency and stable pure-red LEDs

Nature Keyu Wei, Tong Zhou, Yuanzhi Jiang et al. Feb 27, 2025 DOI: 10.1038/s41586-024-08503-9

Biggest-ever AI biology model writes DNA on demand

Nature Ewen Callaway Feb 27, 2025 DOI: 10.1038/d41586-025-00531-3

Thermal Ca2+/Mg2+ exchange reactions to synthesize CO2 removal materials

Nature Yuxuan Chen, Matthew W. Kanan Feb 27, 2025 DOI: 10.1038/s41586-024-08499-2

A Swell Diagnosis

New England Journal of Medicine Ann Cheung, Christos P. Kotanidis, Abigail Schubach et al. Feb 27, 2025 DOI: 10.1056/nejmp2414534

Nationwide, Couple-Based Genetic Carrier Screening

New England Journal of Medicine Feb 27, 2025 DOI: 10.1056/nejmc2500317

The Moral Injury of Inhaler Prescribing

New England Journal of Medicine William B. Feldman, Gregg Furie Feb 27, 2025 DOI: 10.1056/nejmp2412383

Case 7-2025: A 65-Year-Old Woman with Weakness, Back Pain, and Pancytopenia

New England Journal of Medicine Rebecca K. Leaf, Brandon H. Messick, Catherine B. Meador et al. Feb 27, 2025 DOI: 10.1056/nejmcpc2412515

The Emerging Threat of H5N1 to Human Health

New England Journal of Medicine Michael G. Ison, Jeanne Marrazzo Feb 27, 2025 DOI: 10.1056/nejme2416323