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The impact of canine-assisted intervention on stress reduction among university students in Thailand
Stress negatively impacts university students, leading to adverse outcomes. While canine-assisted intervention (CAI) has been shown to reduce self-reported stress, no studies have investigated stress levels and associated biomarkers in dogs and students simultaneously. This study examined salivary cortisol, blood pressure, and pulse rate in 122 university students experiencing self-reported moderate to high stress before an encounter with a dog (T1), immediately before meeting a dog (T2), and after spending 15 minutes interacting with a dog (T3). Participants assessed their stress level using a visual analog scale, and blood pressure and pulse rate were measured at three time points. Salivary cortisol was also measured at T1 and T3. Six privately owned dogs, all in good health and comfortable with strangers, participated in the intervention sessions. Salivary and fecal cortisol samples from the dogs were collected in the morning before commencing activities, at noon, and in the evening after human interactions ended. The results showed that the expectation of interacting with dogs reduces self-reported stress, pulse rate, and salivary cortisol, which remained significantly lower after the interaction. Salivary cortisol concentrations in dogs did not differ throughout the day. By contrast, fecal glucocorticoid metabolite concentrations during the week dogs interacted with students were higher (P = 0.0012) than those during the week post-experiment, which, based on behavior, appeared to indicate positive stimulation. These findings highlight the potential of integrating CAI into university stress management programs. Future research could explore extending these benefits to community dogs, long-term effects, and enhancing accessibility to this form of stress relief.
The development of specific emotion comprehension components in 1285 preschool children
The impact of work-family conflict on job burnout among community social workers in China
In China, for community social workers, work-family conflict has become a common phenomenon that may harm their well-being. Based on the analysis of a survey of community social workers in four cities in China, this study demonstrated that community workers’ work-family conflict significantly affects burnout, role overload mediates the relation between work-family conflict and burnout, and cognitive crafting negatively moderates the relation between role overload and burnout. The conclusions validate the job crafting theory and enrich the research on job burnout under the JD-R model. The practical significance of the study is that on the one hand, community and individual workers can effectively alleviate burnout by clarifying their roles. On the other hand, it also reminds managers that they should pay attention to the physical and mental health of social workers to enable them to develop healthily.
LCD-AHP-TRIZ methodology enhances low-carbon principles in smart product design
Deciphering the structural consequences of R83 and R152 methylation on DNA polymerase β using molecular modeling
DNA polymerase β, a member of the X-family of DNA polymerases, undergoes complex regulations both in vitro and in vivo through various posttranslational modifications, including phosphorylation and methylation. The impact of these modifications varies depending on the specific amino acid undergoing alterations. In vitro, methylation of DNA polymerase β with the enzyme protein arginine methyltransferase 6 (PRMT6) at R83 and R152 enhances polymerase activity by improving DNA binding and processivity. Although these studies have shown that methylation improves DNA binding, the underlying mechanism of enhancement of polymerase activity in terms of structure and dynamics remains poorly understood. To address this gap, we modeled the methylated enzyme/DNA complex and conducted a microsecond-long simulation in the presence of Mg ions. Our results revealed significant structural changes induced by methylating both R83 and R152 sites in the enzyme. Specifically, these changes caused the DNA fragment to move closer to the C- and N-subdomains, forming additional hydrogen bonds. Furthermore, the cross-correlation map demonstrated that methylation enhanced long-range correlations within the domains/subdomains of DNA polymerase β, along with an increase in the linear mutual information value between the domains/subdomains and DNA fragments. The graph connectivity network also illustrated that methylation modulates the information pathway and identifies residues exhibiting long-distance coupling with the methylated sites. Our results provide an atomic-level understanding of the structural transition induced by methylation, shedding light on the mechanisms underlying the methylation-induced enhancement of activity in DNA polymerase β.
Comparative analysis of organoid, air-liquid interface, and direct infection models for studying pathogen–host interactions in endometrial tissue
Measuring real-time violence exposure and its impact on intimate partner violence perpetration among adolescents
Background Intimate partner violence (IPV) has dire health consequences. To intervene, it is critical we first understand why young men perpetrate IPV. One theory is that men who experience violence are more likely to perpetrate violence. We used real time data to examine how daily and repeat experiences of violence affect IPV behaviors. Methods We enrolled 498 males aged 15-19 years in Soweto, South Africa during 2020-2022. We collected data through weekly mobile phone surveys (n = 12,603) delivered over a year. Generalized linear mixed effect models were used to fit IPV perpetration as a function of past-24-hour violence victimization; models included indicators for between-person and within-person components of victimization. Findings In at least one survey submitted, 13% of boys reported perpetrating physical IPV and 5% perpetrating sexual IPV. Any victimization in the past 24-hours significantly increased the odds of physical (OR 4.00) and sexual violence perpetration (OR 2.45). When examined individually, sexual violence victimization had the strongest association (OR of 7.96 for physical and 4.88 sexual IPV perpetration). We also examined the between-person influence of victimization. Boys who experienced more violence on average (a higher person-centered mean exposure) were substantially more likely to perpetrate both physical IPV and sexual IPV as compared to boys with overall low levels of victimization. Conclusion Adolescent boys who experience violence are more likely to use violence against their partners that same day. To break this cycle, it will be critical to understand the mechanisms by which proximal victimization triggers onward violence perpetration. Both the current findings and the next steps highlight the importance of real-time, repeated data collection.
Illuminating ecology and distribution of the rare fungus Phellinidium pouzarii in the Bavarian Forest National Park
Abstract Due to their cryptic lifestyle, hidden diversity and a lack of ecological knowledge, conservation of wood-inhabiting fungi continues to be a niche interest. Molecular methods are able to provide deeper insights into the ecology of rare fungal species. We investigated the occurrence of the rare wood-inhabiting fungus Phellinidium pouzarii across the Bavarian Forest National Park in Germany using a fruit body survey, amplicon sequencing and qPCR. Additionally, we sequenced the genome of P. pouzarii and characterized the chemical substances responsible for its distinctive scent. Our approach gave matching results between amplicon sequencing and qPCRs, however, we found no evidence that P. pouzarii is more abundant in the National Park than we can assume based on fruit body inventories, underlining the species’ critically endangered status. Genomics revealed P. pouzarii’s repertoire of ligninolytic enzymes, pointing towards a white rot lifestyle. Two main components of P. pouzarii’s distinct odour we identified (2-phenylethanol, methyl p-anisate) are known to act as insect attractants and/or to possess antimicrobial properties.
Correction: Neuroprotective effect of Kaempferol Glycosides against brain injury and Neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke
Comparing ISO 4049 and Fourier-transform infrared spectroscopy for assessing ambient light sensitivity in dental resin composites
Impact of a three-week full leg cast immobilization on infant crawling kinetics and spatiotemporal parameters
Despite its importance in the development of mobility in infants, there is a general lack of quantified data on infant crawling, and a specific lack of understanding of crawling kinetics, which includes the relative weightbearing and force generation among the four limbs. Moreover, because of the difficulty of measurement and study design, there is no longitudinal quantification of the impact of a perturbation to typical development, such as limb immobilization. This study measured kinetic and spatiotemporal outcomes in a typically developing infant prior to a fracture that necessitated a long-leg cast that immobilized the left knee and ankle, while crawling with the cast, and again one day after cast removal, and two weeks post. The study utilized a pressure-sensing mat to generate outcomes. Crawling in the cast resulted in a 37% decrease in speed, a shift of weight toward the arms (toward the right arm in particular), and a shift from double and quadruple limb support toward triple limb support. Upon removal of the cast, the unweighting and limb support patterns persisted, while speed recovered and actually exceeded baseline. Triple limb support was 12% at baseline, 28% in the cast, and 32% immediately following cast removal. Two weeks later, the value had dropped back to 17%, while speed continued to increase following a linear trend vs. age. These data provide insight into an infant’s ability to reorganize crawling kinematics, and the persistence of that reorganization following remobilization.
Malagasy flea microbiota results from a combination of vertically transmitted and environmentally acquired microbes
Study on the failure of oil-contaminated wheel-rail conditions
The phenomenon of adhesion improvement during wheel-rail sliding has been experimentally verified under water conditions. However, the academic community is in agreement that, for oil that is also fluid, the adhesion characteristic curve under oil conditions exhibits a single peak, making adhesion improvement through wheel-rail sliding impossible. To investigate whether a similar adhesion improvement phenomenon exists under high-viscosity oil medium conditions as observed under water condition, this study conducted wheel-rail adhesion tests on oil-contaminated interfaces within a slip ratio up to 80%. The test results demonstrate that under higher wheel-rail slip, an adhesion improvement phenomenon also occurs on oil-contaminated rail surfaces, although it is more stringent compared to water conditions. The essence of this adhesion improvement is due to the lubrication failure of oil caused by temperature. Finally, this study analyzes the failure conditions of the oil-contaminated interface and its influencing factors, determining the thermal failure temperature range of the oil film.
Continuous spectroscopic monitoring of urinary catheter output: advancements and clinical implications
Abstract Urine diagnostics are crucial for identifying urological disorders and systemic diseases. Monitoring bladder catheters for urine output and early signs of urinary tract infections (UTIs) is essential but labor-intensive and prone to documentation errors. Recent advances in electronic monitoring and spectroscopy offer potential improvement in this process. This study introduces a novel smart sensor system for urinary catheters, enabling digital, continuous, automated real-time spectroscopic urine monitoring. A prototype consisting of a mini-spectrometer integrated with a custom lens array and hyperspectral illumination source was developed for urine analysis. It measures light intensity across 288 channels (340–850 nm) from multiple angles and exposure times, capturing detailed spectral data. Analyzing 401 urine samples from 168 patients, statistical models in R software were used to assess the dependency between spectral data and clinical laboratory values. The prototype accurately detected response variables like bilirubin, erythrocytes, pH, protein, specific gravity, and urobilinogen, with AUC values indicating good to very good discrimination. Response variables like glucose and nitrite, which do not absorb within the measured spectrum, showed minimal correlation. Our smart catheter system presents the potential for a significant advancement in urine monitoring, providing continuous, accurate analysis of parameters absorbing within the visible light spectrum.
Preschool children of parents who screen positive for mental health problems have an increased risk of subsequent mental disorders: Findings from a longitudinal follow-up study in Sweden
Research has shown associations between parental and child mental health problems. However, there is a paucity of Swedish studies on this topic. Investigating this link in a Swedish context could inform preventive interventions aimed at reducing mental health problems in affected families. This longitudinal cohort study aimed to explore the association between parental mental health problems and children’s subsequent mental disorders in Sweden. We used data on children, 3–5 years old, whose mothers (n = 6379) and fathers (n = 6218) had responded to the 12-item General Health Questionnaire for assessment of parental mental health problems using a cut-off of ≥12 points. The children were followed for approximately seven years with regard to subsequent mental disorders, collected from the Swedish National Patient Register. The associations between parental mental health problems and children’s mental disorders were explored through Cox-regression models. In unadjusted Cox regression models, mothers (HR: 1.63, 95% CI: 1.37–1.94) and fathers (HR: 1.36, 95% CI: 1.12–1.65) with mental health problems were more likely to have children diagnosed with a subsequent mental disorder than mothers and fathers with no mental health problems. In adjusted models controlling for children’s emotional and behavioral problems and parental sociodemographic factors, the associations remained significant for mothers’ mental health problems (AHR: 1.33, 95% CI: 1.12–1.59), but not for fathers’ (AHR: 1.14, 95% CI: 0.93–1.40). Children with emotional and behavioral problems, whose parents were single or living apart and whose parents had lower educational levels also had an elevated risk of being diagnosed with a mental disorder. Maternal mental health problems and child emotional and behavioral problems during the preschool years may serve as risk factors for subsequent child mental disorders. Assessment of these problems at child health services in Sweden could facilitate delivery of interventions to promote parental and child mental health.
Dynamic evaluation of winter wheat’s freezing resistance under different low-temperature periods and durations
Gamma activity concentration from building materials: Estimation of gamma absorption and indoor radon concentration in Katsina State, Nigeria
In this research, nineteen (19) samples were collected and analyzed with the following objectives: to evaluate the activity concentration of radionuclides, assess gamma absorption, determine indoor radon concentration, and evaluate the public health impact of building materials used in Katsina State, Nigeria. The study aimed to provide critical data that would inform safe construction practices and regulatory compliance. Samples were sourced locally from various quarry sites, while materials such as cement, paint, tiles, and ceiling materials were purchased from local markets. The methodology involved measuring radionuclide activity concentrations using gamma-ray spectroscopy with a Thallium-doped Sodium Iodide (NaI (Tl)) detector, a highly sensitive method suitable for detecting gamma emissions from radionuclides. Radon gas was identified as the primary radiation source. Results revealed varying activity concentrations of radionuclides across different building materials. Most samples, except for Gravel, Brown Clay (Zone A and C), Kaolin, and Fired Clay Bricks, were below the recommended limits for radionuclide. Similarly, for , except for Cement and Thatch, samples were generally below the average value of 35 Bq/kg. However, several samples including Gravel, Paint, Brown Clay (Zones A, B, C), Thatch, Mud Clay, Laterite, Neem tree, Limestone, Fired Clay Bricks, and Gypsum exceeded the average value of 30 Bq/kg for . The overall average activity concentrations across samples were : 232.421, : 11.791, and : 51.1858 all in Bq/kg. The average Radium equivalent and Gamma index was 113.8 Bq/kg and 0.22, respectively, with an alpha index of 0.11. The external and internal hazard indexes averaged 0.2292 and 0.3102, indicating that these materials pose no significant radiological health risk when used in construction, as all values are below international guidelines of 370 Bq/kg and 1 mSv/y. This study concludes with a recommendation for public awareness on the effects of radiation and the need for continued monitoring and regulation of radiation exposure. The significance of this study lies in its contribution to public health and safety, supporting regulatory compliance and helping to prevent potential health risks associated with construction materials.
Counterfactual explanations of tree based ensemble models for brain disease analysis with structure function coupling
Effects of mental fatigue on isometric mid-thigh pull performance and muscle activities
This study investigated the effects of mental fatigue on rate of force development (RFD) and peak force during an isometric mid-thigh pull (IMTP), as well as its impact on muscle activation measured by electromyography (EMG) median frequency. Sixteen healthy, resistance-trained males completed two sessions: a control condition and a mentally fatigued state induced by a 30-minute modified Stroop task. IMTP performance and muscle activation were assessed before and after the mental fatigue task. Mental fatigue significantly reduced RFD in the later phase of force generation, specifically within the 20%-80% of maximum force interval (RFD2080) (p = 0.022, d = 0.638). In contrast, no significant changes were observed in RFD within the initial 0-100 milliseconds (RFD100) or 0-200 milliseconds (RFD200) of contraction, nor in peak force. Additionally, mental fatigue led to a significant increase in EMG median frequency for the rectus femoris during the initial 0-1 second interval (p = 0.040, d = -0.609), with no significant changes in the medial gastrocnemius or other time intervals. These findings suggest that mental fatigue primarily impacts the later stages of force development, affecting the ability to sustain and develop force over time without compromising peak force. The increase in EMG median frequency for the rectus femoris indicates a possible compensatory response to mental fatigue, underscoring the complex influence of cognitive stress on neuromuscular function. This study highlights the importance of considering mental fatigue in activities requiring sustained or progressively increasing force production.