Browse Articles
Discover research articles across all indexed journals
Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy
Parallel attention recursive generalization transformer for image super-resolution
Observing time-dependent energy level renormalisation in an ultrastrongly coupled open system
Abstract Understanding how strong coupling and memory effects influence energy levels in open quantum systems is a fundamental challenge. Here, we experimentally probe these effects in a two-level open system coupled to a single-mode quantum environment, using Ramsey interferometry in a trapped ion. Operating in the strong coupling regime, we observe both dissipative effects and time-dependent energy shifts of up to 15% of the bare system frequency, with the total system effectively isolated from external environments. These dynamic shifts, likely ubiquitous across quantum platforms, arise solely from ultra-strong system-mode interactions and correlation build-up and are accurately predicted by the minimal-dissipation Ansatz. Our approach identifies these as generalised Lamb shifts, matching conventional predictions on time-average. We provide experimental fingerprints supporting the Ansatz of minimal-dissipation, thereby suggesting it as a testable quantum thermodynamics framework and establishing a foundation for future benchmarks in strong-coupling quantum thermodynamics and related technologies.
Thin Skin in Cushing’s Syndrome
Phenylacetylcarbinol biotransformation by disrupted yeast cells using ultrasonic treatment in conjunction with a dipropylene glycol mediated biphasic emulsion system
Wafer-scale platform for on-chip 3D radio frequency lumped passive components using metal self-rolled-up membrane technique
Eight Days a Week — BALANCING Duration and Efficacy
Development and validation of machine learning-based prediction model for outcome of cardiac arrest in intensive care units
HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1
Outcomes of a Program to Reduce Birth-Related Mortality in Tanzania
Identification biomarkers and therapeutic targets of disulfidptosis-related in rheumatoid arthritis via bioinformatics, molecular dynamics simulation, and experimental validation
Self-assembly, interlocking, interconversion and anion-binding catalysis in phenoxazine-based Pd2L4 and Pd4L8 coordination cages
Axillary Surgery in Breast Cancer — Primary Results of the INSEMA Trial
Identification and validation of biomarkers related to ferroptosis in idiopathic pulmonary fibrosis
Abstract Idiopathic pulmonary fibrosis (IPF) is a kind of interstitial lung disease (ILD). It has a high incidence rate and mortality. Its pathogenesis remains unclear. So far, no effective methods have been found for the early diagnosis of IPF. Ferroptosis has been reported to be critical in the initiation and progression of IPF. Therefore, our aim was to identify the hub gene related to ferroptosis co-expressed in the peripheral blood and pulmonary tissue of patients with IPF. Sequencing data were obtained from the Gene Expression Omnibus database. A comprehensive analysis was conducted on the differentially expressed genes (DEGs) to extract ferroptosis-related differentially expressed genes (FRDEGs). The results showed that ferroptosis-related signal paths were highly enriched in IPF, and 10 FRDEGs were identified.The hub gene was predicted through protein-protein interactions (PPI) and Cytoscape. The diagnostic utility of the hub gene was proven by enzyme-linked immunosorbent assay (ELISA) in serum and by immunohistochemistry (IHC) in pulmonary tissues. The results of ELISA indicated that the levels of ATM in the serum of patients with IPF were significantly lower than the normal levels. In contrast, the results of IHC showed that the expression of ATM in the pulmonary tissues of IPF patients exhibited a notably elevated trend. The immune status was assessed by the CIBERSORT method and so was the relevance between ATM and immune cells. These findings unveiled significant differences in various immune cell types in peripheral blood and pulmonary tissue between the IPF group and the control group. Furthermore, ATM was associated with various immune cells. This study suggests that as a ferroptosis-related gene, ATM assumes a pivotal role in the diagnosis and treatment of IPF. This discovery presents a novel approach for the clinical diagnosis and therapy of IPF.
Functionally constrained human proteins are less prone to mutational instability from single amino acid substitutions
Abstract Missense mutations that disrupt protein structural stability are a common pathogenic mechanism in human genetic disease. Here, we quantify potential disruption of protein stability due to amino acid substitution and show that functionally constrained proteins are less susceptible to large mutational changes in stability. Mechanistically, this relates to greater intrinsic disorder among constrained proteins and to increased B-factors in the ordered regions of constrained proteins. This phenomenon means that constrained proteins exhibit smaller stability effects due to missense mutations, and partly explains why overtransmission of pathogenic missense variation is less prevalent in genetic disorders characterised by protein truncations. We show that the most functionally constrained proteins are depleted of both destabilising and overly-stabilising amino acid variation in disease-free populations. Despite this, amino acid substitutions with large stability effects in functionally constrained proteins are still highly prevalent among pathogenic human genetic variation. Importantly, we observe that there are approximately five times more missense variants with large stability effects than there are unambiguous loss-of-function mutations. Missense variants with disruption of stability effects recapitulate the per-gene patterns of functional constraint observed with protein truncating loss-of-function variation, yet their relative abundance abrogates difficulties encountered when estimating functional constraint for the shortest human genes.
Case 8-2025: A 72-Year-Old Woman with Altered Mental Status and Acidemia
A two phase differential evolution algorithm with perturbation and covariance matrix for PEMFC parameter estimation challenges
Programmable mRNA therapeutics for controlled epigenomic modulation of single and multiplexed gene expression in diverse diseases
Disparities in use of physical restraint and chemical sedation in the emergency department by patient housing status
Background A growing body of research has found there to be disproportionate physical restraint and chemical sedation use for historically marginalized populations in the emergency department (ED). This association has been examined with regard to patient race, ethnicity, sex, and age. Preliminary research has highlighted the ways in which unhoused status may also relate to the use of physical restraint and chemical sedation in the ED. Given the adverse health outcomes associated with these methods in the ED, further research is needed to explore the relationship between patient housing status and physical restraint/chemical sedation use in more depth. Methods We conducted a cross-sectional study of all ED visits among patients aged 18 years of age and older presenting to eight hospitals within a regional healthcare network in New England between January 1, 2013, and December 31, 2021. Descriptive statistics and mixed effects logistic regression models nesting by patient were used to characterize the relationship between housing status and likelihood of restraint and/or sedation use. Findings Restraint orders were found in 3,160 (5.7%) visits by unhoused patients, compared to 44,155 (1.5%) for housed patients. Unhoused status was significantly associated with restraint/sedation use (adjusted odds ratio = 1.45, 95% CI 1.36-1.54). Conclusion Our study identified a significant association between housing status and ED restraint and sedation use after adjusting for demographic factors and chief complaints. This finding has important implications pertaining to the care of unhoused patients in the ED and for examination of structural factors like housing status and their impact on psychiatric emergency care.