Browse Articles

Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, 18F-SPAL-T-06 and 18F-C05-05

Development and validation of a dynamic prognostic nomogram for conditional survival in hepatocellular carcinoma: an analysis from the Korea Liver Cancer Registry

Exploring the impact of self-efficacy social support and learning environment on clinical performance anxiety in student nurses

Author Correction: Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

Widefield ultra-high-density optical breast tomography system supplementing x-ray mammography

Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis

Disentangling the effects of various risk factors and trends in lung cancer mortality

Multi-interface licensing of protein import into a phage nucleus

Pervasive impact modification of pristine lunar clasts

Relationship between plasma atherogenic index and incidence of cardiovascular diseases in Chinese middle-aged and elderly people

An operating system for networked quantum computers is a huge practical step forward

Copper-catalysed dynamic kinetic asymmetric C−O cross-coupling to access chiral aryl oxime ethers and diaryl ethers

Author Correction: Protective effect of low-dose lactulose in dextran sulfate sodium induced ulcerative colitis model of rats

In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer

Abstract Recently, a conceptually new mass analyzer was introduced by pairing a quadrupole Orbitrap mass spectrometer with an asymmetric track lossless (Astral™) analyzer. This system provides >200 Hz MS/MS scanning speed, high resolving power, sensitivity, and mass accuracy. Due to its speed, the instrument allows for a narrow-window data-independent acquisition (nDIA) strategy, representing a new technical milestone in peptide-centric proteomics. However, this new system may also be applied to other complex and clinically important proteomes, such as the human plasma N-glycoproteome. Here, we evaluate the Orbitrap Astral mass spectrometer for the in-depth analysis of the plasma N-glycoproteome and pioneer a dedicated nDIA workflow, termed “nGlycoDIA”, on glycopeptide enriched and crude plasma. This strategy leads to the cumulative identification of over 3000 unique glycoPSMs derived from 181 glycoproteins in just 40 minutes and covers a dynamic range of 7 orders of magnitude for a glycopeptide enriched plasma sample. Notably, we detect several glycosylated cytokines that have reported plasma concentrations in the ng/L range. Furthermore, shortening the gradient to 10 min still allows for the detection of almost 1850 (95% CI [1840-1860]) unique glycoPSMs, indicating that high-throughput in-depth clinical plasma glycoproteomics may be within reach.

Evidence-Based Work Design — Bridging the Divide

Dielectric identification method and system design of coal gangue based on frequency shift characteristics

Author Correction: Unveiling mechanisms and onset threshold of humping in high-speed laser welding

Middle Meningeal Artery Embolization for Subdural Hematoma

Artificial intelligence-powered prediction of AIM-2 inflammasome sequences using transformers and graph attention networks in periodontal inflammation

Transient non-soluble noble metal transport in hydrothermal ore systems

Abstract The transport of noble metals (Au, Ag) by metal-rich melts in hydrothermal ore systems is now acknowledged as a complementary mechanism to complexing ligands in solution. However, it is unclear where/when both mechanisms coexist and whether metal-rich melts can be physically transported by hydrothermal fluids. Here we show evidence for a suspension-like transport of nano-to-micron-sized metal-rich sulfide-sulfosalt melts within epithermal fluids at <400 °C, forming irregular and bleb-like polymineral inclusions of Ag-Au-Cu-Pb(-Fe-Zn)-As-Sb-S-Se upon cooling. These polymineral inclusions, 5 nm to 40 µm in size, are cogenetic with fluid inclusions in quartz. Numerical modeling based on particle fluidization and settling theory shows hydrothermal fluids can mechanically transport metal-rich sulfide-sulfosalt nano-micromelts at fluid flow rates <10–1 m/s. The chemical similarity between nano- and micron-scale polymineral inclusions suggests the coalescence of nanomelt precursors during transient transport from their source(s) to deposition sites, playing a key role in noble metal mineralization.