Browse Articles

Development and validation of predictive models for distant metastasis and prognosis of gastroenteropancreatic neuroendocrine neoplasms

Kinetics of Concurrent Seed Growth and Cation Exchange in Transforming Cu_2-xS Nanocrystals to CuGaS₂ Nanorods

The association between dietary acid load and indices of insulin resistance

Surface Chemical Coordination Stabilizes Ni-Rich Cathodes for High-Energy Li-Metal Batteries

Aptamer-Guided, Hydrolysis-Resistant Deoxyoxanosine Enables Epitope- and Moiety-Selective Conjugation to Nonengineered Proteins Even in Complex Environments

Bio-nanoparticles sensor couple with smartphone digital image colorimetry and dispersive liquid–liquid microextraction for aflatoxin B1 detection

Gout drives metabolic dysfunction-associated steatotic liver disease through gut microbiota and inflammatory mediators

Oral administration of antimicrobial peptide MPX can effectively regulate LPS-mediated testicular oxidative stress and blood‒testis barrier damage

Insights from rock bridge experiments about tensile fracture of the locked section in slopes with stepped joints

The impact of invasive Sinanodonta woodiana (Bivalvia, Unionidae) and mussel macroparasites on the egg distribution of parasitic bitterling fish in host mussels

Abstract Facilitative and competitive interactions among coexisting parasite species, as well as among alternative host species, produce considerable ecological and evolutionary responses to host-parasite relationships. Such effects can be illuminated by impacts of non-native species on relationships in local communities. We used the association between parasitic European bitterling fish (Rhodeus amarus) and unionid mussels (which host bitterling eggs in their gills) to test the effects of the invasive Chinese pond mussel (Sinanodonta woodiana) and the presence of non-bitterling mussel macroparasites on the pattern of host mussel use by the bitterling across 12 unionid mussel communities with the absence or presence of S. woodiana (and variation in duration of coexistence with local species). While all six European mussel species were used by the bitterling (with the prevalence of > 30% in Unio spp.), no S. woodiana individual was infected by the bitterling. The presence of S. woodiana did not affect bitterling eggs distribution in native mussels. Large native mussels hosted more bitterling. Infection by non-bitterling parasites, mostly water mites (prevalence 47%) and trematodes (25%), did not affect rates of bitterling parasitism. We discuss our results in the context of the rapid evolution of non-native species in their new range and its implication on mussel conservation.

Routine intracoronary imaging-guided left main coronary intervention

Impact and elastic modulus of coal mining on terrestrial ecosystems

Disentangling the Component Processes in Complex Planning Impairments Following Ventromedial Prefrontal Lesions

Damage to the ventromedial prefrontal cortex (vmPFC) in humans disrupts planning abilities in naturalistic settings. However, it is unknown which components of planning are affected in these patients, including selecting the relevant information, simulating future states, or evaluating between these states. To address this question, we leveraged computational paradigms to investigate the role of vmPFC in planning, using the board game task “Four-in-a-Row” (18 lesion patients, 9 female; 30 healthy control participants, 16 female) and the simpler “Two-Step” task measuring model-based reasoning (49 lesion patients, 27 female; 20 healthy control participants, 13 female). Damage to vmPFC disrupted performance in Four-in-a-Row compared with both control lesion patients and healthy age-matched controls. We leveraged a computational framework to assess different component processes of planning in Four-in-a-Row and found that impairments following vmPFC damage included shallower planning depth and a tendency to overlook game-relevant features. In the “Two-Step” task, which involves binary choices across a short future horizon, we found little evidence of planning in all groups and no behavioral differences between groups. Complex yet computationally tractable tasks such as “Four-in-a-Row” offer novel opportunities for characterizing neuropsychological planning impairments, which in vmPFC patients we find are associated with oversights and reduced planning depth.

A cross-sectional study on healthcare seeking behavior among Saudi women in Riyadh

Abnormal Local Cortical Functional Connectivity due to Interneuron Dysmaturation after Neonatal Intermittent Hypoxia

Prematurely born infants often experience frequent hypoxic episodes due to immaturity of respiratory control resulting in disturbances of cortical development and long-term cognitive and behavioral abnormalities. We hypothesize that neonatal intermittent hypoxia alters maturation of cortical excitatory and inhibitory circuits that can be detected early with functional MRI. C57BL/6 mouse male and female pups were exposed to an intermittent hypoxia (IH) regimen from P3 to P7, corresponding to preterm humans. Adult mice after neonatal IH exhibited motor hyperactivity and impaired motor learning in complex wheel tests. Patch-clamp and evoked field potential recordings revealed increased glutamatergic synaptic transmission. To investigate the role of GABAergic inhibition on glutamatergic transmission during the developmental, we applied a selective GABAA receptor inhibitor picrotoxin. A decreased synaptic inhibitory drive in the motor cortex was evidenced by miniature IPSC frequency on pyramidal cells, multi-unit activity recording in vivo with picrotoxin injection, and decreased interneuron density. There was also an increased tonic depolarizing effect of picrotoxin after IH on Betz cells’ membrane potential on patch-clamp and direct current potential in extracellular recordings. The amplitude of low-frequency fluctuation on resting-state fMRI was larger, with a larger increase in regional homogeneity index after picrotoxin injection in the IH group. The increased glutamatergic transmission, decreased numbers, and activity of inhibitory interneurons after neonatal IH may affect the maturation of connectivity in cortical networks, resulting in long-term cognitive and behavioral changes. Functional MRI reveals increased intrinsic connectivity in the sensorimotor cortex, suggesting neuronal dysfunction in cortical maturation after neonatal IH.

Design of a novel long-acting insulin analogs by acetylation modification and compared with insulin Icodec

Development and performance evaluation of alternative road construction material using clay and recycled concrete debris

Synthesis of Titania nanowires doped with Cd on the based Polycalix[4]resorcinarene for photocatalytic oxidation of aromatic alcohols under LED irradiation

Valence fragmentation dynamics of a promising low global warming etching gas CF3CHCF2

Abstract C3HF5 (CF3CHCF2, KSG14), a promising low global warming potential (GWP < 1) alternative to traditional perfluorocarbon etching gases for advanced integrated circuit manufacturing, particularly for high-aspect-ratio SiO2/SiN stacked layers in 3D flash memory. This study investigates the dissociative photoionization dynamics of C3HF5 across 10.0–26.0 eV. Ion yield curves and breakdown diagrams reveal that C3HF5 primarily fragments into C3HF5 +, C3F5 +, C3HF4 +, C3F4 +, C2F3 +, and CF3 + ions. Appearance Energies of these fragments, determined from the ion yield curves, indicate fragmentation pathways at low electronic transitions. These findings underscore C3HF5’s potential as an environmentally friendly etching gas with excellent performance characteristics.

Mapping Eye, Arm, and Reward Information in Frontal Motor Cortices Using Electrocorticography in Nonhuman Primates

Goal-directed reaches give rise to dynamic neural activity across the brain as we move our eyes and arms and process outcomes. High spatiotemporal resolution mapping of multiple cortical areas will improve our understanding of how these neural computations are spatially and temporally distributed across the brain. In this study, we used micro-electrocorticography (µECoG) recordings in two male monkeys performing visually guided reaches to map information related to eye movements, arm movements, and receiving rewards over primary motor cortex, premotor cortex, frontal eye field, and dorsolateral prefrontal cortex. Time–frequency and decoding analyses revealed that eye and arm movement information shifts across brain regions during a reach, likely reflecting shifts from planning to execution. Although eye and arm movement temporally overlapped, phase clustering analyses enabled us to resolve differences in eye and arm information across brain regions. This analysis revealed that eye and arm information spatially overlapped in motor cortex, which we further confirmed by demonstrating that arm movement decoding performance from motor cortex activity was impacted by task-irrelevant eye movements. Phase clustering analyses also identified reward-related activity in the prefrontal and premotor cortex. Our results demonstrate µECoG's strengths for functional mapping and provide further detail on the spatial distribution of eye, arm, and reward information processing distributed across frontal cortices during reaching. These insights advance our understanding of the overlapping neural computations underlying coordinated movements and reveal opportunities to leverage these signals to enhance future brain–computer interfaces.