Browse Articles

Investigating Fe and Cr doping effects on thermoelectric efficiency in Mg3Sb2 through first-principles calculations for sustainable energy solutions

Enhancing T-Cell Infiltration and Immunity in Solid Tumors via DNA Nanolinker-Mediated Monocyte Hitchhiking

Self-supervised VICReg pre-training for Brugada ECG detection

Mass Transport-Dependent C–C Bond Formation for CO Electroreduction with Alkali Cations

The association between body mass index and asthma in children: a cross‑sectional study from NHANES 1999 to 2020

Coherent Vibrational Dynamics in an Isolated Peptide Captured with Two-Dimensional Infrared Spectroscopy

Comprehensive analysis of senescence-related genes identifies prognostic clusters with distinct characteristics in glioma

C–C Cleavage/Cross-Coupling Approach for the Modular Synthesis of Medium-to-Large Sized Rings: Total Synthesis of Resorcylic Acid Lactone Natural Products

Leaf rust resistance in wheat and interpretation of the antifungal activity of silver and copper nanoparticles

Abstract Wheat production is jeopardized by Puccinia triticina, the pathogen responsible for wheat leaf rust. This study assessed the impact of silver (Ag) and copper (Cu) nanoparticles (NPs) on the control of wheat leaf rust disease and the underlying mechanisms of disease resistance. The application of the two nanoparticles resulted in a reduction of spore germination and an extension of both incubation and latent periods. A common type of infection resulted in a reduction in both the length and width of pustules. It reduced receptivity value (number of pustule cm2) compared to untreated wheat plants by altering the physiological and biochemical responses of wheat plants and cell walls’ physical and mechanical strength. The application of Ag + Cu NPs stimulates the biosynthesis of defense-related molecules crucial for P. triticina inoculation and latent periods. Furthermore, molecular docking studies were conducted to assess the effects of Cu-chitosan nanoparticles (Ag & CuNp) and their mechanisms in disease management.

Less-Dominant Resonance Configuration of Propargyl Radical Leads to a Growth Mechanism for Polycyclic Aromatic Hydrocarbons that Preserves the Cyclopenta Ring

Assessment of surface sediment properties and heavy metal contamination in typical urban areas of the Yellow River, China

Structure and pH Dependence of Membranolytic Mechanisms by Truncated Oxidized Phospholipids

Investigation of risk-aware dynamic accident monitoring and early warning technologies for chemical production processes

Off-Equilibrium Hydrothermal Synthesis of High-Entropy Alloy Nanoparticles

Author Correction: Complete chloroplast genomes of 13 species of the Impatiens genus for genomic features and phylogenetic relationships studies

Solution Synthesis of Single Crystalline Zinc Nanowires

Dynamic sealing simulation and performance optimization of conical rubber core in rotary blowout preventer

Impact of Reaction Environment on Photogenerated Charge Transfer Demonstrated by Sequential Imaging

Insights into GLP-1 and insulin secretion mechanisms in pasireotide-induced hyperglycemia highlight effectiveness of Gs-targeting diabetes treatment

Stimulus-Dependent Expression of <i>Bdnf</i> Is Mediated by ATF2, MYT1L, and EGR1 Transcription Factors

Neurotrophins like BDNF have a key role in the proper functioning of the central nervous system, influencing numerous processes like memory formation and behavior. An imbalance in BDNF levels can lead to a wide range of diseases, including depression and neurodevelopmental disorders. While the potential therapeutic effects of BDNF are well-recognized, there is a knowledge gap in understanding the mechanisms governing BDNF expression levels. Here, we focused on the regulation of Bdnf gene expression in response to different stimuli, specifically studying the effects of neuronal activity and BDNF-TrkB signaling on Bdnf transcription in cultured neurons from rats of either sex. We used in vitro DNA pulldown combined with mass spectrometry to determine transcription factors that interact with the Bdnf promoters upon different stimuli and validated numerous known regulators, such as USF and AP1 family, and novel candidate regulators using reporter assays. We show that the USF family of transcription factors is specifically recruited after membrane depolarization, whereas the AP1 family participates in Bdnf regulation only after BDNF-TrkB signaling. We further describe ATF2, MYT1L, and EGR family as novel regulators of Bdnf expression by demonstrating their direct binding to Bdnf promoters using chromatin immunoprecipitation assays both in vitro and in vivo, showing their functional role in Bdnf gene expression and ultimately identifying their regulatory cis -elements in Bdnf promoters. Furthermore, our results show competition between ATF2, CREB, and AP1 family in regulating Bdnf levels. Collectively, our results provide insight into the regulation of Bdnf expression upon different stimuli.