Quantitative photoacoustic tomography of blood oxygenation enhanced by Monte Carlo modeling
Abstract
We present a Monte Carlo-enhanced photoacoustic tomography (MC-PAT) system for quantitative three-dimensional mapping of tissue optical properties and blood oxygenation. Combining Monte Carlo light transport with finite-element acoustic inversion, the system achieved accurate absorption coefficient quantification (0.44 ± 0.02 mm−1, 1.85% deviation) and high spatial resolution (250 μm). In vivo pilot studies (n = 3) demonstrated reliable measurements (0.42 ± 0.02 mm−1, 2.78% deviation) and clear arteriovenous differentiation (arterial: 97.8 ± 0.8% sO2; venous: 74.5 ± 1.3% sO2) with 0.8% error vs pulse oximetry. MC-PAT shows potential for functional vascular studies and future clinical translation.
Article Details
Journal Info
Applied Physics Letters
American Institute of Physics
Authors (7)
Linghui Gong
Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology and College of Photonic and Electronic Engineering, Fujian Normal University 1 , Fuzhou 350000,
Chao Cai
Hai Lin
School of Advanced Materials
Yidan Zhang
Zhaoyu Wang
Frontiers Science Center for New Organic Matter, Tianjin Key Lab for Rare Earth Materials and Applications, Renewable Energy Conversion and Storage Center (RECAST), School of Materials Science and Engineering, National Institute for Advanced Materials
Zequan Xu
Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology and College of Photonic and Electronic Engineering, Fujian Normal University 1 , Fuzhou 350000,
Yubin Liu