Parallel independent voltage computing along dendrites of CA3 pyramidal neurons
Abstract
Dendritic computation contributes to information processing in cortical circuits. Hippocampal CA3 plays a central role in navigation, but how the dendrites of CA3 pyramidal neurons process information in vivo remains largely unknown. Using voltage imaging across dendrites and somata of CA3 pyramidal neurons during virtual reality–guided navigation in mice, we found that the dendritic arbor comprises multiple independent computational units that can dynamically couple to or dissociate from somatic activity, depending on behavioral conditions. Dendritic activity shapes subcellular representations of space, reward, and context through conditional coupling to the somatic output. Furthermore, spatially cotuned dendrites retain their coordination during sharp-wave ripples. These findings demonstrate that past, present, and future representations coexist within the dendritic arbor of CA3 pyramidal neurons, collectively shaping behaviorally relevant neuronal coding.
Article Details
Journal Info
Science
American Association for the Advancement of Science
Authors (9)
Asako Noguchi
Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Satoshi Terada
Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
George N. Zakka
Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY, USA.
Cliodhna O’Toole
Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY, USA.
Luke Reynolds
Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY, USA.
Michelle Ann Land
Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Balázs J. Rózsa
BrainVisionCenter, Budapest, Hungary.
François St-Pierre
Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Attila Losonczy
Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.