Neural circuits for valence updating in social memory
Abstract
Social animals recognize familiar conspecifics and selectively avoid harmful ones. As social relationships shift, continuous updating of social valence is essential, yet the underlying neural mechanisms remain unclear. Here, by artificially transforming a previously neutral conspecific into an aggressive one, we show that valence updating depends on enhanced synaptic connectivity and physiological changes within the hippocampal ventral CA1 (vCA1)–basolateral amygdala (BLA)–nucleus accumbens (NAc) circuit. Following defeat, social memory engram neurons in the vCA1 strengthened their connections with BLA neurons carrying negative valence. The vCA1–BLA–NAc neural circuit flexibly regulates adaptive social behaviors.
Article Details
Journal Info
Science
American Association for the Advancement of Science
Authors (10)
Narutoshi Suto
Laboratory of Behavioral Neuroscience, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Tokyo, Japan.
Mu-Yun Wang
Laboratory of Behavioral Neuroscience, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Tokyo, Japan.
Shota Morikawa
Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Myung Chung
Laboratory of Behavioral Neuroscience, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Tokyo, Japan.
Kentaro Tao
Laboratory of Behavioral Neuroscience, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Tokyo, Japan.
Ziyan Huang
Laboratory of Behavioral Neuroscience, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Tokyo, Japan.
Yuji Ikegaya
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Haruki Takeuchi
Graduate School of Science, The University of Tokyo, Tokyo, Japan.
Shinichiro Kira
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Teruhiro Okuyama
Laboratory of Behavioral Neuroscience, Institute for Quantitative Biosciences (IQB), The University of Tokyo, Tokyo, Japan.