Black phosphorene-enhanced Raman spectroscopy for sensitive detection of DNA nucleotides
Abstract
In this study, we propose black phosphorene (BP) for surface-enhanced Raman spectroscopy of DNA nucleotides. BP-enhanced Raman spectroscopy provides superior enhancement compared to other 2D materials, such as graphene and molybdenum disulfide, for biomolecular detection. We show that BP significantly amplifies the Raman signals of DNA nucleotides, enabling more sensitive and accurate detection of individual nucleotides. This enhancement may be attributed to the strong charge transfer with biomolecules and anisotropic structure, which increases molecular dipole moments when positioned on its surface. These factors lead to stronger molecular interactions and improved Raman signal sensitivity. Our findings highlight BP as a promising platform for biosensor applications, paving the way for more precise biomolecular sensing and advanced diagnostics.
Article Details
Journal Info
Applied Physics Letters
American Institute of Physics
Authors (10)
Ferdinand Nouaye
School of Applied and Engineering Physics, Mohammed VI Polytechnic University 1 , Ben Guerir 43150,
Mohammed Amlieh
School of Applied and Engineering Physics, Mohammed VI Polytechnic University 1 , Ben Guerir 43150,
Soukayna Boulaassafre
Faculty of Medical Sciences, UM6P Hospitals, Mohammed VI Polytechnic University 3 , Ben Guerir 43150,
Younes Akabli
School of Applied and Engineering Physics, Mohammed VI Polytechnic University 1 , Ben Guerir 43150,
Sidi Abdelmajid Ait Abdelkader
School of Applied and Engineering Physics, Mohammed VI Polytechnic University 1 , Ben Guerir 43150,
Afaf Yaden
School of Applied and Engineering Physics, Mohammed VI Polytechnic University 1 , Ben Guerir 43150,
Vivek Chaudhary
School of Applied and Engineering Physics, Mohammed VI Polytechnic University 1 , Ben Guerir 43150,
Reda Ben Mrid
Faculty of Medical Sciences, UM6P Hospitals, Mohammed VI Polytechnic University 3 , Ben Guerir 43150,
Rachid El Fatimy
Faculty of Medical Sciences, UM6P Hospitals, Mohammed VI Polytechnic University 3 , Ben Guerir 43150,
Abdelouahad El Fatimy