Background-free microwave-induced thermoacoustic imaging by magnetic field modulation

G Guojia Huang (Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University 1 , Guangzhou 510080,) Y Yu Wang S Shanxiang Zhang (MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University 2 , Guangzhou 510631,) F Famin Huang (MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University 1 , Guangzhou 510631,) H Huan Qin (Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy)

Abstract

Microwave-induced thermoacoustic (TA) imaging is a potential noninvasive method for high resolution detection of deep tissues. However, background signals from non-target areas can limit imaging contrast. Here, we proposed a reversible switch microwave-induced TA differential imaging using the ferromagnetic resonance effect to achieve high-contrast and background-free imaging. The ferromagnetic resonance of ferromagnetic materials under the combined action of alternating magnetic field and biased static magnetic field can enhance microwave absorption and further produce stronger TA signal. The results demonstrated that the conversion of strong and weak TA signals of ferromagnetic materials can be realized by controlling the switch of biased static magnetic field, so as to achieve high-contrast and background-free TA differential imaging. This technology provides a potential approach for high-contrast and background-free microwave-induced TA imaging in complex biological tissues.

Article Details

Volume / Issue Vol. 126, Issue 21
Published May 26, 2025
ISSN 0003-6951
Publisher American Institute of Physics

Journal Info

Applied Physics Letters

American Institute of Physics

ISSN: 0003-6951 Physical Sciences

Authors (5)

G

Guojia Huang

Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University 1 , Guangzhou 510080,

Y

Yu Wang

S

Shanxiang Zhang

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University 2 , Guangzhou 510631,

F

Famin Huang

MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University 1 , Guangzhou 510631,

H

Huan Qin

Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy