Nature Communications
Articles in this Issue
Engineering unnatural cells with a 21st amino acid as a living epigenetic sensor
Organocatalytic enantioselective [2π + 2σ] cycloaddition reactions of bicyclo[1.1.0]butanes with α,β-unsaturated aldehydes
Abstract Bicyclo[2.1.1]hexanes (BCHs), three-dimensional benzene bioisosteres characterized by high sp 3 -carbon content,...
Temperature-dependent dynamic disproportionation in LiNiO2
Abstract Nickelate materials offer diverse functionalities for energy and computing applications. Lithium nickel oxide (LiNiO 2...
Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke
Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis
Silk-enabled conformal intraventricular interfaces for minimally invasive neural recordings
Abstract Flexible neural interfaces capable of monitoring subcortical neuronal activity facilitate the study of deep brain neural circuits and their interactions with the cortex. How...
DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes
A US case-control study to estimate infant group B streptococcal disease serological thresholds of risk-reduction
Abstract Maternal vaccines to prevent infant Group B Streptococcus (GBS) disease have progressed through phase II develop...
Photocatalytic non-oxidative dehydrogenation of ethane to ethene with near unit selectivity
AgentMD: Empowering language agents for risk prediction with large-scale clinical tool learning
Abstract Clinical calculators play a vital role in healthcare, but their utilization is often hindered by usability and dissemination challenges. We introduce AgentMD, a novel langua...
Water adlayers bridging metal spillover to boost catalytic activity
FAP+ fibroblasts orchestrate tumor microenvironment remodeling in renal cell carcinoma with tumor thrombus
Selecting fitted models under epistemic uncertainty using a stochastic process on quantile functions
Abstract Fitting models to data is an important part of the practice of science. Advances in machine learning have made it possible to fit more—and more complex—models, but have also...
Niche-associated Type IV collagen promotes GLP-1/Notch receptor activation in the C. elegans germline
Fundamental role of spatial positioning of Mycobacterium tuberculosis in mycobacterial survival in macrophages
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
Concurrent improvements in maize yield and drought resistance through breeding advances in the U.S.Corn Belt
Abstract Drought increasingly challenges rainfed maize ( Zea mays L.) production worldwide, with pressures expected to in...
Predicting hypotension, syncope, and fracture risk in patients indicated for antihypertensive treatment: the STRATIFY models
Abstract Antihypertensives are associated with increased risk of syncope, hypotension, and fractures, but the highest-risk individuals are unclear. This study ai...
Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface
Abstract Proton conductance across cell membranes serves many biological functions, ranging from the regulation of intracellular and extracellular pH to the generation of electrical...
Copper-catalyzed enantioselective synthesis of γ-butenolides via radical diversification of allenoic acid
Structural mechanisms of assembly, gating, and calmodulin modulation of human olfactory CNG channel
Abstract Mammalian cyclic nucleotide-gated (CNG) channels play crucial roles in visual and olfactory signal transduction. In olfactory sensory neurons, the nativ...
Formal pyridine meta-azidation and its application for the synthesis of diazepines, ring-fused δ-carbolines and 1,2,3-triazolylpyridines
Abstract The nitrogen atom serves as an important structural element in pharmacologic studies, highlighting the critical role of nitrogen-containing heterocycles in drug discovery. L...
A cortex-wide multimodal microscope for simultaneous Ca2+ and hemodynamic imaging in awake mice
Author Correction: AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 mice
Categorical and phenotypic image synthetic learning as an alternative to federated learning
Abstract Multi-center collaborations are crucial in developing robust and generalizable machine learning models in medical imaging. Traditional methods, such as centralized data shar...