Nature Communications
Articles in this Issue
Large Language Models lack essential metacognition for reliable medical reasoning
Recent changes in ENSO’s impacts on the summertime circumglobal teleconnection and mid-latitude extremes
Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation
Abstract The pathological deposition of tau and amyloid-beta into insoluble amyloid fibrils are pathological hallmarks of Alzheimer’s disease. Molecular chaperones are important cellular fac...
Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species
Potential plant extinctions with the loss of the Pleistocene mammoth steppe
Abstract During the Pleistocene-Holocene transition, the dominant mammoth steppe ecosystem across northern Eurasia vanished, in parallel with megafauna extinctions. However, plant extinction...
A multi-model study to inform the United States’ 2035 NDC
Deep neural networks have an inbuilt Occam’s razor
Abstract The remarkable performance of overparameterized deep neural networks (DNNs) must arise from an interplay between network architecture, training algorithms, and structure in the data...
Metagenome-guided culturomics for the targeted enrichment of gut microbes
Abstract The gut microbiome significantly impacts human health, yet cultivation challenges hinder its exploration. Here, we combine deep whole-metagenome sequencing with culturomics to selec...
Vialess heterogeneous skin patch for multimodal monitoring and stimulation
Abstract System-level wearable electronics require to be flexible to ensure conformal contact with the skin, but they also need to integrate rigid and bulky functional components to achieve...
Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT
Abstract Conjugation plays a major role in dissemination of antimicrobial resistance genes. Following transfer of IncF-like plasmids, recipients become refractor...
Early life microbial succession in the gut follows common patterns in humans across the globe
All-angle unidirectional flat-band acoustic metasurfaces
White light-emitting electrochemical cells based on metal-free TADF emitters
Abstract The attainment of white emission from a light-emitting electrochemical cell (LEC) is important, since it enables illumination and facile color conversio...
Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies
Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium
The small GTPase MRAS is a broken switch
Massively parallel homogeneous amplification of chip-scale DNA for DNA information storage (MPHAC-DIS)
Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways
Inhalable biohybrid microrobots: a non-invasive approach for lung treatment
Abstract Amidst the rising prevalence of respiratory diseases, the importance of effective lung treatment modalities is more critical than ever. However, current drug delivery systems face s...
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling
Abstract Investigating the genetic factors influencing human birth weight may lead to biological insights into fetal growth and long-term health. We report analy...
Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa
Abstract Endotypes are characterized by the immunological, inflammatory, metabolic, and remodelling pathways that explain the mechanisms underlying the clinical presentation (phenotype) of a...
Increased but not pristine soil organic carbon stocks in restored ecosystems
Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton
Coordinated representations for naturalistic memory encoding and retrieval in hippocampal neural subspaces
Principled neuromorphic reservoir computing
Abstract Reservoir computing advances the intriguing idea that a nonlinear recurrent neural circuit—the reservoir—can encode spatio-temporal input signals to enable efficient ways to perform...