Nature Communications
Articles in this Issue
Chromosome-level genomes of two Bracteacoccaceae highlight adaptations to biocrusts
Asymmetric small-molecule acceptor enables suppressed electron-vibration coupling and minimized driving force for organic solar cells
Abstract Minimizing the energy loss, particularly the non-radiative energy loss (ΔE nr), without sacrificing the charge collection efficiency, is the key to further improve the p...
A fire deficit persists across diverse North American forests despite recent increases in area burned
Resonant inelastic X-ray scattering tools to count 5 f electrons of actinides and probe bond covalency
Abstract The actinides possess a complex electronic structure, making their chemical and physical properties among the least understood in the periodic table. Ad...
A primary quantum current standard based on the Josephson and the quantum Hall effects
Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes
Abstract Barrier-to-autointegration factor (BAF) associates with mitotic chromosomes and promotes nuclear envelope assembly by recruiting proteins, such as Lamins, required for the reconstru...
Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression
Abstract The 26S proteasome is a multi-catalytic protease that serves as the endpoint for protein degradation via the ubiquitin-proteasome system. Proteasome fun...
Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility
Stepwise amplification of circularly polarized luminescence in indium-based metal halides by regulating their structural dimension
Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity
Abstract Oncogene amplification is a key driver of cancer pathogenesis. Both breakage fusion bridge (BFB) cycles and extrachromosomal DNA (ecDNA) can lead to high oncogene copy numbers, but...
Transferrable, wet-chemistry-derived high-k amorphous metal oxide dielectrics for two-dimensional electronic devices
Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle
Abstract Cyclin dependent kinase 2 (CDK2) regulates cell cycle and is an emerging target for cancer therapy. There are relatively small numbers of tumor models that exhibit strong dependence...
Segregation-dislocation self-organized structures ductilize a work-hardened medium entropy alloy
Synthetic transmembrane DNA receptors enable engineered sensing and actuation
Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification
Abstract Cell polarity involves the asymmetric distribution of cellular components such as signalling molecules and organelles within a cell, alterations in cell...
Prion protein promotes copper toxicity in Wilson disease
Abstract Copper (Cu) is a vitally important micronutrient, whose balance between essential and toxic levels requires a tightly regulated network of proteins. Dysfunction in key components of...
Self-driving lab for the photochemical synthesis of plasmonic nanoparticles with targeted structural and optical properties
Modeling and designing enhancers by introducing and harnessing transcription factor binding units
Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity
Iron-catalysed stereoselective NH transfer enables dynamic kinetic resolution of sulfoxides
R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania
Abstract Genomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartment...
Rising groundwater table due to restoration projects amplifies earthquake induced liquefaction risk in Beijing
An impermeable copper surface monolayer with high-temperature oxidation resistance
Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression
Abstract Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learning-based tool that allows disent...