Nature Communications
Articles in this Issue
Neurons exploit stochastic growth to rapidly and economically build dense dendritic arbors
Abstract Dendrites grow by stochastic branching, elongation, and retraction. A key question is whether such a mechanism is sufficient to form highly branched dendritic morphologies. Alternat...
α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex
Abstract Prenatal nicotine exposure impairs fetal cortical grey matter volume, but the precise cellular mechanisms remain poorly understood. This study elucidates the role of nicotinic acety...
SE(3)-equivariant ternary complex prediction towards target protein degradation
Abstract Targeted protein degradation (TPD) has rapidly emerged as a powerful modality for drugging previously “undruggable” proteins. TPD employs small molecules like PROTACs and molecular...
Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation
Abstract Mitochondrial dysfunction contributes to aging and diseases like neurodegeneration and cardiovascular disorders. Mitochondria transfer and transplantation (MTT) represent promising...
Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responses
Abstract Macrophages initiate pathogen-appropriate immune responses with the activation dynamics of transcription factor NFκB mediating specificity. Live-cell imaging revealed the stimulus-r...
PI3Kγ signaling controls trafficking of CD8+ T cells between lymphoid and non-lymphoid organs and drives hypertension in a murine model
A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins
Abstract More than a half of plasma proteins are N-glycosylated. Most of them are synthesized, glycosylated, and secreted to the bloodstream by liver and lymphoi...
Connecting metal-organic framework synthesis to applications using multimodal machine learning
Abstract Every year, researchers create hundreds of thousands of new materials, each with unique structures and properties. For example, over 5000 new metal-organic frameworks (MOFs) were re...
A generalized platform for artificial intelligence-powered autonomous enzyme engineering
Biomimetic synthesis of vesicular covalent organic frameworks by gemini surfactants for in-situ enzyme cascade immobilization
Cavity-magnon polaritons strongly coupled to phonons
DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation
Visualization of a multi-turnover Cas9 after product release
Abstract While the most widely used CRISPR-Cas enzyme is the Cas9 endonuclease from Streptococcus pyogenes (Cas9), it exh...
Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models
Direct observations of airflow separation over ocean surface waves
Abstract A large portion of the kinetic energy found within the ocean originates from the growth of ocean surface waves under the action of wind. However our understanding of wind wave dynam...
Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma
Abstract While immunotherapeutic targeting of cell surface proteins is an increasingly effective cancer therapy, identification of new surface proteins, particul...
Loss of CFHR5 function reduces the risk for age-related macular degeneration
Abstract Age-related macular degeneration (AMD) is a prevalent cause of vision loss in the elderly with limited therapeutic options. A single chromosomal region around the complement factor...
Natural nanoparticle complexes at water-water interfaces
Rhodopsin charge diffusion computations disclose contrasting color-tuning mechanisms
Olivine’s high radiative conductivity increases slab temperature by up to 200K
Abstract The thermal evolution of slabs governs their subduction dynamics and the transport of water into Earth’s interior. However, current slab subduction models often neglect the contribu...
A global map of travel time to access veterinarians
Molecular architecture and catalytic mechanism of human glycogen debranching enzyme
A multicenter longitudinal study of cholinergic subgroups in Parkinson disease
Abstract Parkinson disease (PD) is a heterogeneous syndrome. There is a need for biology-driven subtyping to inform specific therapeutic strategies. In a two-center study with de novo and es...
Zero-field chiral edge transport in an intrinsic magnetic topological insulator MnBi2Te4
Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy
Abstract From molecules to organelles, cells exhibit recurring structural motifs across multiple scales. Understanding these structures provides insights into their functional roles....