Nature Communications
Articles in this Issue
Current practices in the study of biomolecular condensates: a community comment
Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope
Apelin as a CNS-specific pathway for fenestrated capillary formation in the choroid plexus
Abstract The cerebral vasculature consists of a heterogenous network of blood vessels, including barrier-forming capillaries with blood-brain-barrier (BBB) properties and fenestrated capilla...
Speed modulations in grid cell information geometry
Abstract Grid cells, with hexagonal spatial firing patterns, are thought critical to the brain’s spatial representation. High-speed movement challenges accurate localization as self-...
Coordinated multi-level adaptations across neocortical areas during task learning
Abstract The coordinated changes of neural activity during learning, from single neurons to populations of neurons and their interactions across brain areas, remain poorly understood...
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Abstract DNA replication stress is a hallmark of cancer that is exploited by chemotherapies. Current assays for replication stress have low throughput and poor resolution whilst bein...
Genetic determinants of pOXA-48 plasmid maintenance and propagation in Escherichia coli
Abstract Conjugative plasmids are the main drivers of antibiotic resistance dissemination contributing to the emergence and extensive spread of multidrug resista...
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens
Direct observation of electrostatic charging in 3D printing
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury
Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma
Quantifying collective interactions in biomolecular phase separation
Abstract Biomolecular phase separation is an emerging theme for protein assembly and cellular organisation. The collective forces driving such condensation, howe...
Modular synthesis of CF2-containing compounds with PhSO2CF2H reagent through difluoromethylene radical anion synthon strategy
Integrative proteogenomic characterization of Wilms tumor
Temporal complexity of terrestrial ecosystem functioning and its drivers
On-chip, inverse-designed active wavelength division multiplexer at THz frequencies
Serological proteomic characterization for monitoring liver fibrosis regression in chronic hepatitis B patients on treatment
Reverse polarity of amide nitrogen enables expedient access to N-cyano amides
Data-driven organic solubility prediction at the limit of aleatoric uncertainty
Abstract Small molecule solubility is a critically important property which affects the efficiency, environmental impact, and phase behavior of synthetic processes. Experimental determinatio...
O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism
Hierarchically ordered porous transition metal compounds from one-pot type 3D printing approaches
TrimNN: characterizing cellular community motifs for studying multicellular topological organization in complex tissues
Abstract The spatial organization of cells plays a pivotal role in shaping tissue functions and phenotypes in various biological systems and diseased microenviro...
Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus
Abstract Corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator throughout the nervous system. The thalamic reticular nucleus (...
The three stages of religious decline around the world
Abstract Religiosity tends to decline across generations. However, religious decline is more pronounced in some countries and the diminishing aspects of religion vary by context. To explain...
The chronODE framework for modelling multi-omic time series with ordinary differential equations and machine learning
Abstract Many genome-wide studies capture isolated moments in cell differentiation or organismal development. Conversely, longitudinal studies provide a more dir...