Nature Communications
Articles in this Issue
Cu single-atom embedded g-C3N4 nanosheets rehabilitate multidrug-resistant bacteria infected diabetic wounds via photoswitchable cascade reaction
Abstract To tackle elevated blood glucose, multidrug-resistant (MDR) bacterial infections, and persistent inflammation in diabetic wounds, we present a therapeut...
Enhanced erosion by continental arc volcanism as a driver of the Cambrian Explosion
Coordination-tailored atomic interfaces for selective CH4-to-C2 conversion in aqueous solution
Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance
Abstract The insulin receptor entrains tissue growth and metabolism to nutritional conditions. Complete loss of function in humans leads to extreme insulin resistance and infantile mortality...
Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles
The association between childhood exposure to local wealth inequality and intergenerational income mobility in the United States
Southern Ocean evidence for recurring West Antarctic Ice Sheet destabilization during Marine Isotope Stage 11
Abstract Millennial-scale deoxygenation of Antarctic Bottom Water (AABW) in the Atlantic Southern Ocean during past interglacials was linked to West Antarctic Ice Sheet (WAIS) melt-driven su...
Genome-wide CRISPR Screen Identifies Sec31A as a Key Regulator of Alpha Cell Survival
Changes in continental weathering regimes inhibited global marine deoxygenation during the Paleocene-Eocene thermal maximum
Dual roles of DEAD-box RNA helicase Brr2 in genome stability regulation
Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
The geroprotective potential of chalcones
Abstract Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies...
Frictional healing and induced earthquakes on conventionally stable faults
Abstract Conventional studies suggest that faults in the shallow subsurface resist earthquake nucleation, because their frictional strength increases as slip accelerates (i.e., veloc...
Distinct hydrologic response patterns and trends worldwide revealed by physics-embedded learning
Nuclear entry of AS160 as a transcriptional regulator of satellite cells for muscle regeneration
Of condensates and coats - reciprocal regulation of clathrin assembly and the growth of protein networks
scTFBridge: a disentangled deep generative model informed by TF-motif binding for gene regulation inference in single-cell multi-omics
Semi-crystalline and amorphous materials via multi-temperature 3D printing from one formulation
Abstract Multi-material 3D printing concerns the use of two or more 3D printable materials within a single printed part. The result is a composite that benefits from the combined pro...
Collectivity effect in cluster catalysis under operational conditions
Spin density wave rather than tetragonal structure is prerequisite for superconductivity in La3Ni2O7-δ
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity
Abstract Mechanosensitive ion channels such as Piezo1 have fundamental roles in sensing the mechanical properties of the extracellular matrix. However, whether and how Piezo1 senses...
A motif preferred adenine base editor with minimal bystander and off-targets editing
Rapid adaptive optics enabling near noninvasive high-resolution brain imaging in awake behaving mice
The formation of the ‘footprint of death’ as a mechanism for generating large substrate-bound extracellular vesicles that mark the site of cell death
Abstract Apoptotic cells communicate to phagocytic cells through releasing soluble factors and apoptotic cell-derived extracellular vesicles. However, whether there are additional factors th...
Subcellular mass spectrometry imaging of lipids and nucleotides using transmission geometry ambient laser desorption and plasma ionisation
Abstract Demand for mass spectrometry imaging (MSI) technologies offering subcellular resolution for tissues and cell imaging is rapidly increasing. To accomplish this, efficient analyte ion...