Nature Communications
Articles in this Issue
Cetacean evolution through the lens of ecospace modeling and disparity analyses
Subtype-dependent arrestin engagement of the metabotropic glutamate receptors
Condensin I but not Condensin II is crucial for mitotic chromosome mechanics
Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling
Abstract The estrogen receptor (ER) drives growth in most breast cancers. Endocrine therapy reduces recurrence, however around 30% of cancers relapse. Many recurrences occur years la...
Global patterns of urban heat shaped by climate and morphology
Systematic multi-omic deconvolution of the clinical heterogeneity of Down syndrome
How understanding planet Earth became science
Titan’s organic world
Sustained Direct Electro-epoxidation of Ethylene via a Strain-Gradient CuO–Ag Interface
SAASI: Sampling Aware Ancestral State Inference
Abstract In phylogeography, ancestral state inference methods are used to identify the geographic or host species origin of viral or bacterial lineages and reconstruct their transmis...
Continental-scale genomic surveillance of Plasmodium falciparum malaria across sub-Saharan Africa with rapid nanopore sequencing
Abstract In sub-Saharan Africa, continental-scale genomic surveillance of Plasmodium falciparum malaria is needed to trac...
Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination
Adolescent wellbeing is associated with positive outcomes in early adulthood in a sibling comparison study
Abstract Puberty through adulthood involves major psychological and social change. Prospective evidence on adolescent wellbeing and later outcomes remains limite...
Spatial characterization of skin lesions in discoid and systemic lupus erythematosus
Synthesis of sialylated human milk oligosaccharides by automated glycan assembly
Abstract Sialic acids cap the ends of many glycan chains and play pivotal roles in cell signaling, immunity, and pathogen interactions. However, the fast synthes...
Pharmacological markers of HIV prevention for oral pre-exposure prophylaxis in men who have sex with men
Abstract The human immunodeficiency virus (HIV) infected approximately 1.1 million individuals in 2024. There is no effective vaccine or cure, and funding cuts in resource-limited se...
Geometry of the cumulant series in diffusion MRI
CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
Abstract Menin inhibitors have entered clinical trials for histone lysine methyltransferase 2 A (KMT2A) -rearranged and...
Spin-state regulation of high-entropy Ruddlesden-Popper perovskite oxides for efficient seawater electrolysis
Inter-organ metabolic feedback via BCAA catabolism regulates glucagon-like hormone secretion in Drosophila
Abstract Metabolic homeostasis regulated by nutrient-responsive endocrine hormones is essential for organismal survival. In insects, lipid and carbohydrate mobil...
Asymmetric two-photon response of an incoherently driven quantum emitter
Abstract Quantum emitters promise to emit exactly one photon when pumped by a laser pulse. However, even in ideal systems, re-excitation during the laser pulse duration causes the co...
Short-term action is key for gigaton-scale Direct Air Capture by 2050
Abstract Direct Air Capture (DAC) is widely considered essential for achieving net-zero and net-negative emissions, yet its potential to scale to climate-relevant levels remains unce...