Nature Communications
Articles in this Issue
Warming-driven shifts in global building energy use reshape climate mitigation planning
Coupled Hg isotope dynamics reveal eruption pulses across the Permian–Triassic mass extinction
Natural killer cell-mediated immunosurveillance modulates liver cancer evolution through cancer stemness enhancement and lipid metabolism reprogramming
Low-hygroscopic solvents enable ambient blade coating of efficient perovskite solar cells
Layer-by-layer shear densification for multiscale hierarchical alignment in bulk hydrogels
Current-induced creation and dynamics of embedded magnetic skyrmion bags
Abstract Magnetic skyrmion bags—vortex-like structures hosting multiple skyrmions with tunable topological charge ( Q )—h...
Bone-derived Osterix+ osteolineage cells are a source of tumor-promoting myofibroblastic cancer-associated fibroblasts in breast cancer
Abstract Cancer-associated fibroblasts (CAFs) are major regulators of breast cancer (BC) progression and therapeutic resistance, yet the extent to which CAF hete...
Tumor-resident T cells and dendritic cells form an in situ archetype during immunotherapy response in melanoma
Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer
Abstract Breast cancer remains a leading cause of death worldwide. Although chemotherapy reduces primary and metastatic tumour burden, persisting drug-tolerant tumour cell population...
Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats
Abstract Cocaine use disorder (CUD) is a major public health crisis. The specific genes mediating CUD remain largely unknown. We conducted a genome-wide associat...
Isolation of genome-predicted Caldatribacterium (Atribacterota) reveals pervasive microbial cultivation problem due to folate precipitation
Investigating and inhibiting cathode-side gas generation for practical low-temperature and fast Li-ion batteries
Thermal-decoupled selenization enables kesterite solar cells with 15.3% certified efficiency
Targeting SMC3 deacetylation synergizes with XPO1 inhibition to reprogram the epigenetic landscape and suppress NPM1-mutated acute myeloid leukemia
Light-triggered oxygen redox activity at the edge of cobalt oxyhydroxide for superior water oxidation
Abstract Introducing oxygen redox chemistry into cobalt oxyhydroxide effectively enhances catalytic activity by enabling direct O-O coupling, thereby bypassing t...
TRNAU1AP and PRPF39 establish integrated control over processing of most abundant human non-coding RNAs
Oligoclonal expansion of atypical Vδ2− γδ T cells in Good’s Syndrome
Abstract Good’s syndrome is a rare adult-onset immunodeficiency characterized by thymoma, hypogammaglobulinemia, B-cell lymphopenia, and T-cell dysfunction. Despite well-characterize...
Benchmarking large language models for cell-free RNA diagnostic biomarker discovery
Abstract Large language models can synthesize biomedical knowledge, parse vast amounts of data, and generate code, positioning them as promising tools for biomarker discovery from hi...
Integrating microbial cell factory with new-to-nature photobiocatalysis for de novo biosynthesis of d-homotryptophan
Molecular regulation and physiological role of GOLPH3-mediated Golgi retention
Abstract The Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking converge. How cargo and Golgi-resident proteins travers...
Influenza coinfection inhibits control of mycobacterial infection in a human challenge model
Abstract Mycobacterium tuberculosis infection is a dynamic continuum. Clinical outcomes reflect complex host-pathogen interactions. Epidemiol...
An electron-density point-cloud framework for robust protein-ligand interaction prediction
Abstract Accurate protein-ligand affinity prediction typically depends on precise 3D coordinates, limiting robustness when structures are low-resolution or predicted. We introduce E-...
Switchable adhesion of phase-transition eutectogels with integrated machine learning-enhanced intelligent adhesion sensing
Abstract Switchable adhesion underpins emerging technologies in robotics, microelectronics, and biomedical engineering. However, achieving switchable surface adhesion that can adapt...