Nature Communications
Articles in this Issue
Desegregation of neuronal predictive processing
Abstract Neural circuits construct internal ‘world-models’ to guide behavior. The predictive processing framework posits that neural activity signaling sensory predictions and concur...
Data-driven intelligent carbonization unifies diverse biomass into high-performance hard carbon negative electrodes
Operando insights on stable Cu2+ active sites for efficient electrochemical CO2-to-C2H4 conversion
Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity
Ultrastrong and tough paper structure from densified hybrids of multiscale cellulose fibers
Abstract Replacing petrochemical plastics with sustainable materials requires strategies that combine high mechanical performance with low environmental impact. Here, we report an ul...
A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice
Machine learning assisted single-molecule sensing towards standard-free quantification of per- and polyfluoroalkyl carboxylic acids
Abstract Per- and polyfluoroalkyl carboxylic acids (PFCAs) are of global concern for their ubiquitous presence in the environment. However, precise quantificatio...
Insights into the activation patterns of 1,2-dithiolane unit in biofunctional molecules
Mechanical gating of tendon fibrogenic transcription in systemic sclerosis
Abstract Fibrosis arises from aberrant tissue repair in systemic sclerosis and is characterized by progressive stiffening across multiple tissues, including tendons. How altered tiss...
Extended valley lifetime and giant energy splitting induced by chiral plasmon-valley exciton selective coupling
Spatiotemporal visualization of long-range anisotropic plasmon polaritons in hyperbolic MoOCl2
The evolutionary consequences of behavioural plasticity
Unravelling the role of redox active sites in nitrogen doped cerium oxide for associative ammonia decomposition
Abstract The catalytic decomposition of ammonia under mild conditions is a promising route for green hydrogen production. However, conventional dissociative ammo...
Strong interplay between polar and structural topologies
Periplasmic gatekeeping of phage DNA entry by an rSAM enzyme matured effector with HxS repeats
Butyrate extends health and lifespan in mice with mitochondrial deficiency
Abstract Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. Here, to investigate strategies t...
A hydro-topological strategy enables self-regulating biofilms for sustainable wastewater treatment
Abstract The moving bed biofilm reactor (MBBR) is a cornerstone technology in modern wastewater treatment, yet its performance is often hindered by carrier clogging, which significan...
Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits
Abstract Type 1 diabetes, particularly with childhood onset, is associated with altered neurocognitive traits, yet the underlying biological mechanisms are unclear. Here, we integrat...
Room-temperature ferrimagnetism and polar phase in strained La2CoRuO6 films through 3d-4d cation engineering
4-Hydroxyphenanthrene exacerbates obesity by altering gut microbiota and bile acid metabolism
A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication
Abstract Orthoflavivirus infections represent an increasing public health burden, with several members of the genus emerging or re-emerging globally. Several pre-clinical studies ide...
Dual-metal-doped perovskite adsorbents for efficient removal of humic acid
Cortical-limbic circuit dynamics of approach-avoidance conflict in humans
Abstract Choosing to approach or avoid is common in everyday life and excessive avoidance is a cardinal feature of anxiety disorders. We use intracranial EEG to define a prefrontal-l...
Pan-tumor activity of olomorasib, a next-generation KRAS G12C inhibitor in KRAS G12C-mutant advanced solid tumors: a first-in-human study
Abstract This multicenter, first-in-human Phase 1 study (NCT04956640) evaluated olomorasib (LY3537982), a next-generation KRAS G12C inhibitor designed to enhance...