Nature Communications
Articles in this Issue
Energy, power, and infrastructure demands from electrifying airport ground support equipment at United States airports
Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability
Interchain supramolecular interactions drive nearly 21% efficiency organic solar cells
Abstract A small-molecule acceptor, S-Cb, substituted with a cyclobutyl group that introduces high ring strain, was designed and synthesized. Thanks to the rigid and planar structure...
Exploring how deep learning decodes anomalous diffusion via Grad-CAM
Phosphorylation of SF3B1 by CDK11 orchestrates spliceosome activation via SNIP1-dependent RES complex recruitment
Cardiomyocyte-derived GPX4 stabilizes BNIP3 to facilitate mitophagy and mitigate myocardial ischemia/reperfusion injury
Multi-field coupling enhanced plasmonic Moδ+ active site to efficiently hydrolyze ammonia borane
Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/A2 AMPA receptor core
Abstract AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate the fast component of excitatory neurotransmission. They govern synaptic plasticity that underlies learning and...
Electromagnetic imaging reveals insufficient fluids to explain shallow megathrust creep at the Shumagin Gap
Abstract The Shumagin Gap, a creeping segment of the Alaska subduction zone characterized by tsunamigenic structures, experienced a deep rupture during the July 2020 M7.8 earthquake....
FOXA1 loss drives basal/squamous de-differentiation of prostate cancer and induces an immunosuppressive tumor microenvironment
Abstract FOXA1 is a prostate lineage-specifying transcription factor that is frequently dysregulated or mutated in prostate cancer (PCa). While FOXA1 has been re...
In-situ growth of biomimetic ion-selective membranes via confined molecular encapsulation for superior fluoride/chloride separation
NEK8 kinase-mediated lactate increase impairs antitumor immunity decreasing radiotherapy sensitivity in colorectal cancer
Accumulation of virtual tokens towards a jackpot reward enhances performance and value encoding in dorsal anterior cingulate cortex
The role of the Helmholtz potential on electrocatalytic activity
Abstract The electrification of the chemical industry is required for a rapid reduction of its carbon footprint and necessitates sustainable and highly active el...
Dbf4-dependent kinase finetunes Ino80 function at chromosome replication origins
Abstract The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role during S phase. It phosphorylates the replicative helicase (minichromosome maintenance, MCM complex), w...
Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness
Abstract Disabling hearing impairment is a common human sensory deficit. OTOF is a major deafness gene. It codes for the...
Modulating nuclear stiffness and envelope barrier facilitates AAV nuclear entry and reduces immunogenicity
Metal-dependent and metal-free mechanisms of peptide condensate catalysts
Abstract Condensates formed via liquid-liquid phase separation (LLPS) provide a chemically versatile environment for catalysis through dynamic molecular interact...
Oriented diffusion tailors interfacial strain-polarization coupling for broadband electromagnetic absorption
Small-molecule binding and sensing with a designed protein family
Abstract The de novo design of small-molecule–binding proteins holds great promise as a potential tool to develop sensors on-demand for arbitrary small molecules. Here we combine dee...
Zanubrutinib-rituximab followed by shortened chemoimmunotherapy as frontline treatment for mantle cell lymphoma (CHESS): a phase II trial
Neoantigen evolution and response to checkpoint inhibitor immunotherapy in colorectal cancer
Structural basis for pH-responsive amino acid transport via SLC7A4.
Abstract The transport of amino acids across cell membranes is essential for metabolism, neuronal signalling, and immune system function. The amino acid polyamine organocation (APC)...
IL-22 induces Paneth cell metaplasia in the colonic epithelium of ulcerative colitis, promoting wound healing via REG3A
Role of the primate ventral striatum as a neural hub bridging option valuation and action selection
Abstract Making appropriate decisions relies on the brain’s capacity to evaluate the expected outcomes of available options and select the most rewarding action. The ventral striatum...