Nature Communications
Articles in this Issue
Exploring the feasible net-zero transition pathway in China considering energy system flexibility
Abstract Net-zero energy transition is projected to accelerate the replacement of fossil fuels with renewables, leaving system flexibility resources increasingly scarce. Here, we pre...
VGLL4-driven TEAD4 multimerization orchestrates DNA binding and YAP recruitment
Water-based UV-ozone activation enables aggregation-free processing of MFI nanosheets for membrane fabrication
Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM
Abstract ALECT2 amyloidosis is a rare systemic disease characterized by the pathological deposition of leukocyte cell-derived chemotaxin-2 (LECT2) as amyloid fibrils, primarily affec...
Skeletal editing of tetrahydrofurans to pyrrolidines through O-to-N single atom swap
Metabolic adaptation drives self-organization during skin organoid morphogenesis
Hybrid physics-machine learning models for quantitative electron diffraction refinements
Abstract High accuracy electron microscopy simulations required for quantitative crystal structure refinements face a fundamental challenge: while physical interactions are well-desc...
Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy
Abstract Bispecific immune cell engagers, particularly bispecific T-cell engagers, show limited efficacy in solid tumors such as glioblastoma (GBM) due to systemic toxicities, poor T...
Learning lessons from over-crediting to ensure additionality in forest carbon credits
Abstract Independent evaluations have shown substantial over-issuance of REDD+ (Reducing Emissions from Deforestation and Degradation) credits traded on the voluntary carbon market....
Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepatic steatosis in high fat diet-fed male mice
Proline-promoted electrophilic dichloromethylation of α-enaminones via stereochemically gated resolution
Characterizing gene perturbations in single cells via network divergence analysis
Interactions across hemispheres in prefrontal cortex reflect global cognitive processing
Intrinsic topological Weyl phase transition induced by a magnetostructural transformation in a kagome magnet
Abstract Topological phase transitions provide a unique window into the interplay between structure, magnetism, and Weyl physics in magnetic Weyl semimetals. How...
Sex distorter male drive for resistance-resilient population control of the human malaria vector Anopheles gambiae
Abstract Progress in malaria control has plateaued, prompting the exploration of additional tools. Here, we characterise two germline-specific promoters,...
A synthetic angiotensin II/ACE2-based hormone shunt controlling experimental hypertension
Abstract Arterial hypertension is the leading preventable cause of various life-threatening medical conditions and comorbidities that affect over 1.3 billion adu...
PDK4 drives abdominal aortic aneurysm by promoting smooth muscle cell metabolic reprogramming and NLRP3-mediated pyroptosis
Abstract Abdominal aortic aneurysm (AAA) is a progressive dilation of the abdominal aorta that can rupture and cause catastrophic internal bleeding, yet the mech...
LaMGen: LLM-based 3D molecular generation for multi-target drug design
Inboard advance of arc magmatism regulates mountain building in the Andes
Abstract Debate continues over the mechanisms that govern the tempo and style of arc magmatism and retroarc deformation along ocean-continent plate boundaries. Here we integrate detr...
Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity
Equatorward upper-ocean heat transport from the Southern Ocean boosted interglacial warming
Broadband comb spectroscopy through spectral envelope shaping
Selective membrane wetting of phase-separated giant unilamellar vesicles by coacervate droplets
Interfacial Ru/RuOx heterostructures on carbon support regulate selectivity in lignin hydrodeoxygenation
Abstract Constructing well-defined heterostructure interfaces in catalysts provides an approach to modulate scaling constraints and steer reaction pathways in bi...
Deep visual proteomics uncovers nociceptor diversity and pain targets
Abstract The richness of our somatosensory experience is reflected in the functional diversity of somatic sensory neurons. Single-cell RNA sequencing of sensory...