Nature Communications
Articles in this Issue
Cation-inhibitor and metal–support synergy for efficient and durable hydrogen evolution in natural seawater
Physical mechanisms governing generalization and hallucination in deep learning for imaging through scattering media
Abstract Deep learning has revolutionized computational imaging, yet its real-world deployment remains constrained by two critical challenges: poor generalizatio...
Fault-mediated magma propagation and triggered seismicity revealed by the 2022 São Jorge Azores unrest
Abstract Understanding failed volcanic eruptions is key to mapping magma plumbing and forecasting hazards. Faults and fractures guide magma, but their mechanisms remain unclear due t...
The role of hydration in the removal of glyphosate (GLY) and aminomethylphosphonic acid (AMPA) by nanofiltration membranes
Abstract Nanofiltration can remove glyphosate (GLY) and aminomethylphosphonic acid (AMPA) from water via steric, Donnan, and dielectric exclusions, although the significance of diele...
Ketogenic diet exacerbates DSS-induced colitis through a β-hydroxybutyrate-Thomasclavelia spiroformis-γδ17 T cell axis in mice
Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting
Superstrong and supertough biomimetic nanocellulose composites with gradient bouligand architecture
Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors
Abstract Activation of G protein-coupled receptors (GPCRs) by extracellular ligands is crucial for cellular communication and modulates numerous physiological pr...
Discovery of a novel envelope protein derived from simian retrovirus 2 for pseudotyping retroviral vectors used for production of CAR immune cells
Abstract In this study, we develop a simian retrovirus 2 pseudotyped retrovirus (SRV2 RV) for the generation of CAR-based immune cells. The SRV2 RV exhibits superior gene transductio...
RNA-induced PRC2 inhibition depends on the sequence of bound RNA
Abstract Methyltransferase PRC2 (Polycomb Repressive Complex 2) deposits histone H3K27 trimethylation to establish and maintain epigenetic gene silencing. PRC2 is precisely regulated...
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22
Abstract Targeted protein degradation (TPD) through the ubiquitin-proteasome system is driven by compound-mediated polyubiquitination of a protein-of-interest by...
MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes
Parametrically upscaled model-based predictive platform for fatigue with location-specific microstructural linkages
DxDirector: an agentic large language model driving the full-process clinical diagnosis
Abstract Clinical diagnosis in the real world often begins with ambiguous patient complaints that require iterative reasoning and testing. While large language models (LLMs) increasi...
Neoadjuvant toripalimab plus CapeOX in locally advanced Epstein-Barr virus-associated gastric or gastroesophageal junction adenocarcinoma: a phase Ⅱ trial
The structure of the Vibrio alginolyticus flagellar filament suggests molecular mechanism for the rotation of sheathed flagella
Abstract In several pathogenic bacteria, including Vibrio species, the filament of the bacterial flagellum is encased by...
Machine learning-driven alignment architecture of heterogeneous data with transient varying semantics
Abstract Via cross-correlation algorithms or synchronized acquisition of signals, the alignment of heterogeneous data with unknown semantic time shifts and intermittent semantic vari...
In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Abstract Antibodies are central mediators of the adaptive immune response, and they are powerful research tools and therapeutics. Antibody discovery requires substantial experimental...
The network structure of cross-feeding impacts microbial community diversity under growth-inhibiting stresses
Necking of the active Turkana Rift Zone and the priming of eastern Africa for continental breakup
Multiomics immune profiling of a patient-relevant orthotopic lung cancer model using SEPARATE-Seq
High-throughput single-vesicle imaging platform for direct extracellular vesicle profiling of human plasma
Type I interferon drives T cell responses to amyloid beta in the central nervous system
Abstract Amyloid beta (Aβ) plaque deposition in the central nervous system (CNS) is a hallmark of Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA), triggering robust in...