Nature Communications
Articles in this Issue
Transversely pumped laser driven particle accelerator
Abstract We present a novel acceleration scheme capable of accelerating electrons and ions in an underdense plasma. Transversely Pumped Acceleration (TPA) uses multiple arrays of cou...
Dual recognition of structurally unrelated mildew effectors underlies the broad-spectrum resistance of Pm3e in wheat
Abstract Broad-spectrum resistance genes are highly valuable for sustainable crop protection, yet the molecular basis of their activity is often unknown. The...
Cytoplasmic abundant heat-soluble proteins from tardigrades protect synthetic cells under stress
Global glacier-free topography reveals a large potential for future lakes in presently ice-covered terrain
Abstract Glacier retreat transforms landscapes in polar and mountainous regions. Yet, the topography of the emerging terrain remains poorly known. Here, we prese...
Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations
Abstract Vaults are massive ribonucleoprotein complexes, highly conserved and abundant in eukaryotic cells, yet with unclear function. Their thin-walled barrel-shape architecture is...
Single-molecule kinetic exploration of functional sub-states in an evolving phosphotriesterase
Chiral Brønsted acid-catalyzed kinetic resolution of radical additions
SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration
Abstract Recent advancements in single-cell sequencing technologies have led to the generation of vast amounts of multi-omics data, spurring the development of numerous integration t...
Sediment-modulated seafloor residence time controls efficient organic carbon burial in subduction zones
Population-based genome-wide association study of plasma complex lipid species
Abstract The human lipidome comprises numerous complex lipids, dysregulation of which can contribute to the pathogenesis of a wide range of diseases. Despite the...
In vivo imaging of central nervous system fluid spaces using synchrotron radiation-based micro computed tomography
Abstract Current intravital imaging techniques for the mouse central nervous system (CNS) do not simultaneously provide micrometer-scale spatial resolution, whole-brain coverage, and...
Genome reshaping by Helitron transposons in Fusarium oxysporum TR4 affects secondary metabolism but not virulence
Hybrid magnetic-electric actuation for enhanced motion control and multi-surface operation of Janus microrobots
Collapse and resurgence of the Iceland mantle plume
Abstract Mantle plumes are a fundamental component of the Earth’s convective regime, but their long-term behaviour remains poorly understood. The Iceland plume,...
Adaptive spatial hashing with dual-domain memristive hardware
Cell-free DNA fragmentomics for preeclampsia risk assessment
Abstract Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remain...
Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome
Abstract Bacterial genomes frequently harbor extrachromosomal replicons (ERs) that promote genome plasticity and adaptation, ranging from small plasmids to chrom...
Swimming with robots: investigating fish locomotion, sensing, and schooling behavior with robotic swimmers
Abstract Fish display remarkable locomotor and social abilities, from efficient swimming to coordinated schooling, that have inspired the design of various robotic fish. While roboti...
Reconstructing magmatic histories with 3D diffusion modeling of complex crystals
Structural basis for transport and inhibition of nucleotide sugar transport in pathogenic fungi
Abstract GDP-Mannose transporters are Golgi-localised solute carriers that are essential for the virulence of pathogenic fungi, serving as critical components of...
NELFA supports naïve pluripotency and drives 8C-like state in human embryonic stem cells
Mild-Sunlight-Activated Safe Photodynamic Therapy Using On-Off Polymer Photosensitizers in Wearable Microneedle Patch
PTPN2 inhibition unleashes response to STING agonism in head and neck squamous cell cancer
Abstract cGAS-STING signaling can promote antitumor immunity, and tumor cell STING is suppressed in a variety of cancer subtypes that resist immune checkpoint blockade. Although STIN...
Synergistic Fe/Ni catalysis for electrochemical 1,1-difunctionalization of alkenes
Abstract Alkene 1,1-difunctionalization holds significant importance in organic synthesis due to its ability to effectively enhance the complexity and functionality of molecular fram...
Multicohort analysis unveils axon guidance pathways linking small for gestational age to spirometric restriction
Abstract Children born small for gestational age (SGA) face elevated risks of metabolic, cardiovascular, respiratory, and neurodevelopmental disorders, as well a...