Journal of Clinical Oncology
Articles in this Issue
Non-invasive characterization of intratumoral CD8+ T cells using standard-of-care (SOC) CT and ⁸⁹Zr-crefmirlimab berdoxam PET (CD8-PET) radiomic signature in solid tumors.
2614 Background: Noninvasive estimation of intratumoral CD8+ T-cell density using radiomics may enhance comprehensive immu...
Reproductive and pregnancy-related outcomes among adolescent and young adult female cancer survivors (15–39 years): A nationwide population-based study in South Korea.
12104 Background: As survival rates among adolescent and young adult (AYA) female cancer patients improve, increasing numb...
Trends and burden of retinoblastoma incidence, prevalence, and mortality in the United States, 1990–2023: A retrospective analysis with machine learning projections to 2050.
e22609 Background: Retinoblastoma, a rare intraocular malignancy primarily affecting children, has seen declining age-stan...
Efficacy and safety of engineered TCR-T cell therapy (afami-cel, lete-cel) in pediatric synovial sarcoma.
11569 Background: Synovial sarcoma (SyS) represents ~ 5% of adult soft tissue sarcomas, however, SyS is the most common no...
Inflammatory markers as predictors of pathological complete response in patients with breast cancer after neoadjuvant chemotherapy.
e12653 Background: Breast cancer is the most common cancer and the leading cause of cancer-related death in women. Patholo...
Integrated AI-informed morphologic and spatial transcriptomics features from H&E slides to enable risk stratification of primary melanoma patients.
9559 Background: Tumor proliferative activity and the tumor-stroma microenvironment are key determinants of melanoma aggre...
Barriers to integrating obesity management into cancer survivorship care: Results from a single-institution survey.
e13783 Background: Cancer survivors with obesity are at increased risk of cancer recurrence, cancer-related mortality, and...
Prospective evaluation of AI-assisted documentation and summarization in virtual multidisciplinary cancer conferences.
1614 Background: Multidisciplinary cancer conferences (MCCs) are central to high-quality oncologic decision-making but are...
Rare germline heterozygous pathogenic BLM variants and correlations with co-occurring pathogenic variants and severe treatment-related adverse events in breast cancer.
e12603 Background: The BLM gene encodes a RecQ family DNA helicase. Biallelic pathogenic mutations in BLM cause Bloom synd...
Tele-nutritional collaborative care in patients with stage IV gastrointestinal cancer receiving chemotherapy: A randomized clinical trial.
12043 Background: Cancer cachexia is characterized by systemic inflammation and progressive muscle loss, fundamentally com...
RP2 oncolytic immunotherapy alone and in combination with nivolumab (nivo) in patients with advanced solid tumors: Final safety, efficacy, and biomarker results from the phase 1 first-in-human (FIH) study.
2504 Background: RP2 is an HSV-1-based oncolytic immunotherapy expressing a fusogenic glycoprotein (GALV-GP-R...
High-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplant (PBSCT) for relapsed seminoma: A single-center cohort.
e17013 Background: The optimal salvage therapy for patients with relapsed seminoma remains unsettled. We evaluated clinica...
Phase 1 study of venetoclax combined with a 10-day regimen of decitabine in subjects with high-risk acute myeloid leukemia.
6547 Background: We and others have reported the antileukemic activity of a 10-day regimen of the hypomethylating agent (H...
Efficacy and safety by tumor location in the phase 3 PANOVA-3 trial of Tumor Treating Fields (TTFields) with gemcitabine/nab-paclitaxel in locally advanced pancreatic adenocarcinoma.
e16367 Background: Outcomes of unresectable, locally advanced pancreatic adenocarcinoma (LAPAC) remain poor, with therapy...
Systematic evaluation of machine learning optimization strategies for uveal melanoma detection using ultra-widefield photography.
9560 Background: Early differentiation of uveal melanoma (UM) from benign intraocular lesions remains clinically challengi...
Multi-modal molecular profiling of CDH1 and CLDN18.2 to identify predictive biomarkers for zolbetuximab efficacy in patients with advanced gastric adenocarcinoma: The ZOL-C3 study.
3148 Background: Zolbetuximab is a chimeric monoclonal antibody designed to bind to claudin 18.2 (CLDN18.2) and induce ant...
Mutational signatures as potential predictors of HIPEC response and recurrence in ovarian cancer.
e17577 Background: While Hyperthermic intraperitoneal chemotherapy (HIPEC) has demonstrated overall survival benefit in ad...
Temporal trends in intensive care unit outcomes for lung cancer patients: A 15-year analysis of the MIMIC-IV database.
e20693 Background: Lung cancer care has been transformed over the past decade. Targeted therapies and immunotherapy have e...
Effects of genome-wide modifiers of response to next-generation FGFR inhibitors in solid tumors—An Indian multicentric study.
e23422 Background: FGFR alterations are established actionable drivers in solid tumors, with particular clinical relevance...
Efficacy of immunotherapy-based regimens in Russian patients with <i>EGFR</i> -mutated metastatic NSCLC after EGFR TKI failure: A multi-institution real-world analysis.
e20628 Background: Patients with EGFR-mutated (EGFRm) metastatic non-small cell lung cancer (mNSCLC) generally derive limi...
Myelodysplasia-related mutation dynamics and outcomes in newly diagnosed (ND) acute myeloid leukemia (AML) treated with low-intensity therapy (LIT).
6531 Background: Outcomes of patients (pts) with ND AML with myelodysplasia related gene mutations (MRMs), while tradition...
Outcomes following CAR-T therapy in adults with relapsed/refractory B-ALL according to prior inotuzumab exposure.
e18626 Background: Chimeric antigen receptor T-cell (CAR-T) therapy represents a novel approach to relapsed and refractory...
Women’s perceptions and preferences regarding liquid biopsy for breast cancer screening.
e22548 Background: Liquid biopsy is a potential new noninvasive tool for cancer detection and may address barriers to curr...
Time-restricted eating and metformin (TEAM) in invasive breast cancer or DCIS: A randomized, phase IIb, window-of-opportunity presurgical trial.
10524 Background: Preclinical studies indicate that metformin administered during fasting synergizes with feeding–fasting...
Risk of checkpoint inhibitor pneumonitis associated with anti-angiogenic agents in non–small cell lung cancer: An integrated analysis of meta-analysis of randomized controlled trials, FAERS, and real-world data.
e24163 Background: Immunotherapy with immune checkpoint inhibitors (ICIs) and antiangiogenic treatment represent the stand...