Journal of Clinical Oncology
Articles in this Issue
Patterns of recurrence after perioperative FLOT for resectable gastric cancer: A systematic review and meta-analysis.
e16094 Background: Despite curative-intent resection and perioperative chemotherapy, gastric and gastroesophageal cancer (...
Spatial transcriptomics–guided computational pathology model to stratify docetaxel benefit in metastatic hormone-sensitive prostate cancer: CHAARTED trial (ECOG-ACRIN E3805).
5002 Background: The CHAARTED trial demonstrated improved overall survival (OS) with the addition of docetaxel (DTX) to an...
Rural-urban disparities in chemotherapy administration and quality certifications in Minnesota.
e13563 Background: Rural cancer patients experience disparities in access and outcomes compared to their urban counterpart...
Restoring form, rethinking function: The dual-edged impact of maxillofacial prostheses on survival and complication outcomes in head and neck cancer—A propensity matched analysis.
e18125 Background: Maxillofacial prosthetic rehabilitation restores form and function in patients with head and neck cance...
OncoSphere AI: An agentic AI multidisciplinary clinical workflow support tool.
e13656 Background: Effective multidisciplinary cancer care is bottlenecked by the cognitive burden of synthesizing fragmen...
The characterization and management of immune checkpoint inhibitor–induced pruritus: A retrospective review.
e24167 Background: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies widely used in cancer treatment to block...
Surgical outcomes of sleeve versus standard lobectomy in patients with non–small cell lung cancer: A systematic review and meta-analysis.
e20084 Background: Sleeve lobectomy is a parenchyma-preserving alternative to standard lobectomy for centrally located non...
Defining when and how to support palliative care communication: International consensus on timing and clinician training priorities for adolescents and young adults with cancer.
12103 Background: Early, developmentally appropriate palliative care communication is an international standard for adoles...
Molecular circulating tumor DNA (ctDNA) profiling from patients (pts) treated with zanidatamab + chemotherapy (CT) in first-line (1L) HER2-positive (HER2+) advanced or metastatic gastroesophageal adenocarcinoma (mGEA).
4050 Background: Zanidatamab is a dual HER2-targeted bispecific antibody that binds to HER2 extracellular domains 2 and 4....
From awareness to action: A mixed-method community study on uptake of population-based breast cancer screening in an urban slum of Delhi.
e13574 Background: Delayed diagnosis contributes to poor breast cancer outcomes in low-resource settings. We evaluated the...
Early burden reduction after two doses of cemiplimab in advanced non-melanoma skin cancer.
9583 Background: Advanced non-melanoma skin cancers (NMSC) frequently impose a high disease-related burden—severe pain, ul...
A phase I, open-label, dose-escalation study of CAR001 (mRNA-engineered Nb-CAR.BiTE-γδ T cells) in patients with relapsed or refractory solid tumors.
TPS2674 Background: Solid tumors are characterized by a highly immunosuppressive tumor microenvironment (TME). Key immune...
Determinants of cervical cancer awareness, procedural knowledge, and information sources among Nepali women undergoing HPV screening.
11110 Background: Successful implementation of cervical cancer screening in low- and middle-income countries (LMICs) depen...
Phase II randomised controlled trial on postoperative radiotherapy, in high-risk, resected, non-medullary, non-anaplastic thyroid cancers (THYRO-RT).
6082 Background: Locally advanced thyroid cancers have high rates of locoregional recurrence after standard treatment with...
Biomarker study of BND-22 in combination with cemiplimab in solid tumors.
TPS2676 Background: Immune checkpoint inhibitors benefit only a subset of patients, indicating a need to identify other th...
Immune checkpoint inhibitor–induced autoimmune type 1 diabetes: Clinical characteristics and management outcomes from a multicenter retrospective study.
e23330 Background: Immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L1, and CTLA-4 pathways have significantly impro...
Adebrelimab in combination with anlotinib and chemotherapy as neoadjuvant therapy for resectable stage II-III non–small cell lung cancer (NSCLC): A prospective, single-arm, phase II trial.
e20073 Background: Immunotherapy combined with chemotherapy as neoadjuvant treatment for NSCLC has demonstrated significan...
Longitudinal analysis of PD-1 receptor occupancy in spleen and tumor-infiltrating lymphocytes in a murine model.
e14580 Background: Anti-PD-1 antibodies restore T-cell-mediated anti-tumor immune responses by blocking the interaction be...
Comparative real-world survival outcomes of ribociclib and abemaciclib in breast cancer.
11167 Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i), including ribociclib and abemaciclib, are widely used...
Tumor recurrence or treatment effect? Large multi-institutional evaluation of an AI risk assessment model in glioma and brain metastases.
2080 Background: Distinguishing true tumor recurrence (TuR) from radiation necrosis (RN) on post-treatment MRI scans remai...
First-line GemCis ± immunotherapy vs FGFR inhibition in ctDNA-detected <i>FGFR2</i> fusion–positive advanced cholangiocarcinoma: A real-world analysis.
4159 Background: Advanced cholangiocarcinoma (aCCA) carries a poor prognosis. Approximately 40% of aCCA harbor targetable...
AI-driven TILs spatial analysis to identify high-density hot spots as a superior prognostic marker in triple-negative breast cancer.
e12562 Background: Tumor-infiltrating lymphocytes (TILs) are a robust prognostic biomarker in triple-negative breast cance...
Phase 1/2 study of CLIO-8221, a HER2-targeted, dual-payload exatecan and ATR inhibitor antibody-drug conjugate (ADC) in patients with advanced HER2-expressing solid tumors.
TPS3162 Background: CLIO-8221 is a novel anti-HER2 ADC designed to overcome topoisomerase 1 inhibitor (Topo1i) resistance...
Clinical significance of the preoperative cachexia index as a prognostic predictor in patients with extrahepatic cholangiocarcinoma undergoing radical surgery.
e16336 Background: The cachexia index (CXI) has been proven to have prognostic value in various tumors. Extrahepatic chola...
Oral mucin expression in the early diagnosis of esophagogastric cancer.
e16099 Background: Challenges in early diagnosis of esophagogastric carcinoma (EGC) may partly explain its poor long-term...