Journal of Clinical Oncology
Articles in this Issue
Effect of elinzanetant on sleep disturbance and aspects of quality of life in women with breast cancer experiencing vasomotor symptoms: OASIS-4 subgroup analysis by type of endocrine therapy.
512 Background: In the Phase III OASIS-4 trial, elinzanetant (EZN), a dual neurokinin (NK)-targeted therapy (NK-1 and NK-3...
Outcomes by LymphoMAP archetypes in untreated diffuse large B-cell lymphoma from the POLARIX trial.
7017 Background: Single cell multiomics helped identify three tumor microenvironment archetypes: FMAC, high tumor-associat...
A phase 2 study of androgen deprivation therapy and the androgen receptor ligand–directed degrader (BMS-986365) prior to radical prostatectomy in patients with high-risk localized prostate cancer.
TPS5152 Background: Although radical prostatectomy (RP) is a curative approach for patients (pts) with high-risk localized...
Clinical impact of succinate-dehydrogenase B protein expression in clear cell renal cell carcinoma.
e16511 Background: Succinate-deficiency renal tumors are considered a new entity since WHO 2016 classification. These tumo...
A machine learning (ML)–based six-gene signature for risk stratification and therapeutic target identification in multiple myeloma.
7558 Background: Multiple myeloma(MM) accounts for 10-15% of hematologic malignancies with significant heterogeneity. Curr...
Accelerated failure time as an alternative to Cox proportional hazards for parathyroid carcinoma in the Surveillance, Epidemiology, and End Results database.
e18139 Background: Cox proportional hazards regression is a common model for multivariate survival analysis. This model re...
Evidence implicating human papillomavirus in bladder carcinogenesis: A case-control study.
4594 Background: The etiology of high-risk oncogenic human papillomavirus (HPV) subtypes with signature cytomorphological...
A multicenter, prospective real-world study of irinotecan liposome (II)–based combination regimens in patients with pancreatic ductal adenocarcinoma.
e16399 Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited therapeutic options...
Choosing Wisely Pakistan: A call for value-based oncology practice in resource-limited settings.
e13532 Background: The Choosing Wisely initiative promotes evidence-based oncology care by reducing low-value intervention...
Association of circulating tumor cells with PD-L1 expression and clusters in confirmative tumor thrombus in selective solid cancers.
e16191 Background: Tumor thrombus (TT) is often an incidental, leading direct extension of tumor cells into a blood vein....
Characteristics of patients managed with active surveillance versus treatment for prostate cancer within a large nationwide health system.
e17129 Background: Active surveillance (AS) is broadly endorsed as preferred management for low-grade prostate cancer and...
Potential alternative dosing strategies for FDA-approved oncology biologics based on reanalysis of exposure-response data.
e15135 Background: Many modern oncology biologics were developed using historical maximum tolerated dose paradigms that ar...
Clinical characteristics, treatment patterns, and outcomes of common solid tumors in Arab American patients.
e23407 Background: Arab Americans are frequently misclassified as White in U.S. cancer registries, limiting the study of c...
circRNA signatures associated with BRCA mutation status in ovarian cancer and a RASSF8-derived candidate biomarker.
e17548 Background: Clinically actionable variants (CAVs) in BRCA1 and...
Improving clinical trial enrollment rates among patients with operable invasive breast cancers: An ASCO Quality Training Program initiative.
e23305 Background: Clinical trial participation is essential for advancing cancer care and recommended in National Compreh...
Efficacy and safety of SPH4336 plus endocrine therapy in HR-positive/HER2-negative metastatic breast cancer with brain metastases: A multicenter, single-arm, phase II study.
1076 Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors plus endocrine therapy are standard first-line treatment...
Knowledge-distilled EfficientNets for peripheral blood smear classification.
e14083 Background: Leukemias represent the most common malignancies in children and remain a major source of cancer-relate...
Use of knowledge-distilled EfficientNet to enable rapid, scalable glioma diagnosis.
2040 Background: Accurate preoperative classification of gliomas on MRI according to WHO 2021 integrated diagnosis is esse...
Understanding the role of large language models in cancer mortality prediction: A real-world study.
e23177 Background: Although mortality risk prediction is essential in oncology, risk determinants vary widely across cance...
Trends and disparities in prostate cancer mortality among men with hypertension in the United States: A CDC WONDER analysis (1999–2020).
e17064 Background: Prostate cancer is a major cause of cancer-related mortality among older men in the United States. Hype...
Impact of systemic delays in targeted therapy (TT) access for advanced NSCLC (aNCSLC) with actionable genomic alterations (AGA+) in Alberta, Canada.
e23028 Background: Approval and funding timelines for precision oncology drugs in Canada lag those of other OECD nations....
A randomized phase Ib/II study of enzalutamide (Enza) with and without ribociclib (Rib) in patients with metastatic castrate-resistant prostate cancer (mCRPC) that retains RB expression: RiboX study.
5057 Background: RB function is often attenuated in tumors through hyperphosphorylation; thus, RB activity can be “re-awak...
Impact of transplant on <i>TP53</i> <sup>MT</sup> configurational dynamics in myeloid neoplasms.
6537 Background: Multihit TP53 clonal configurations in myeloid neoplasms (MN) con...
Efficacy and safety of neoadjuvant ICI-based regimens in resectable gastric and GEJ cancer: Updated systematic review and meta-analysis.
e16124 Background: Gastric and gastroesophageal junction (GEJ) cancers remain highly lethal, and durable cure relies on cu...
Impact of chemotherapy on gonadal function in pubertal children with Hodgkin lymphoma.
e22001 Background: Hodgkin lymphoma (HL) in pubertal children carries a high risk of reproductive dysfunction, both due to...