Journal of Clinical Oncology
Articles in this Issue
Impact of AI-based risk stratification integrating routine laboratory data with age on screening volume and multi-cancer early detection yield.
10538 Background: Early cancer detection improves survival, yet population-wide screening remains costly and logistically...
A single-arm, phase 2 study of neoadjuvant mirvetuximab soravtansine and carboplatin for FRα-expressing advanced-stage serous epithelial ovarian, fallopian tube, or primary peritoneal cancer (M25-231; NCT06890338; GOG-3115).
TPS5633 Background: Folate receptor alpha (FRα) has limited expression on normal tissues but is highly expressed in most h...
Clinicopathologic profile and comparative performance of limited next-generation sequencing and qPCR for detection of <i>RAS/RAF</i> mutations in stage IV colorectal cancer (mCRC).
e15576 Background: The implications of limited next-generation sequencing (NGS) compared with quantitative/real-time PCR (...
Treatment of localized pulmonary pleomorphic adenocarcinoma: A systematic review and meta-analysis.
e20040 Background: Pulmonary pleomorphic adenocarcinoma (PPADC) is a rare, aggressive subtype of non-small cell lung cance...
Safety, efficacy, and immunogenicity of adjuvant therapy with personalized cancer vaccine (PCV) RGL-270 in combination with adebrelimab and mFOLFIRINOX in resectable pancreatic ductal adenocarcinoma (PDAC).
4231 Background: Tumor specific neoantigens are peptides carrying somatic mutations presented by HLA molecules and recogni...
Proglumide, gemcitabine (GEM), and nab-paclitaxel (NAB-P) in patients (pts) with pancreatic ductal adenocarcinoma (PDAC): Results of the phase 1 PROGEM trial.
4202 Background: PDAC has a poor prognosis and resistance to therapy due to its desmoplastic and immunosuppressive tumor m...
Failure-to-rescue following acute hepatic decompensation in hospitalized patients with hepatocellular carcinoma in the United States, 2018–2022.
e23119 Background: In hospitalized oncology populations, mortality may be influenced by failure to rescue after acute dete...
Don’t ask, don’t tell: Missing ECOGS and anticancer treatment, neutrophil-to-lymphocyte ratios, and outcomes in hospitalized patients with solid tumors.
e24071 Background: ASCO’s Choosing Wisely campaign has recommended avoiding cancer-directed therapy for patients with ECOG...
Temporal and demographic trends in mortality from multiple myeloma with coexisting mental and behavioral disorders in U.S. adults, 1999–2023.
e22592 Background: Multiple myeloma is a plasma cell malignancy with a persistently high mortality rate; when it occurs in...
EU-OPEN: A novel approach for generating European oncology real-world evidence at scale.
11161 Background: The European Oncology Platform for Evidence Needs (EU-OPEN) is a strategic initiative to generate high-q...
The prognostic impact of epilepsy in glioblastoma: Insights from a systematic review and meta-analysis.
e14038 Background: Epilepsy is a common comorbidity in patients with glioblastoma (GBM) and significantly impacts quality...
Frameworks for improving comprehensive biomarker testing in NSCLC: A multi-stakeholder consensus.
e23121 Background: Despite the availability of numerous targeted therapies for NSCLC, significant barriers persist in ensu...
The effects of specialized сardio-oncological care on the duration of TKI therapy.
e24030 Background: tyrosine kinase inhibitors (TKIs) often cause arterial hypertension (AH) that leads to dose reduction/w...
Spatial mapping of human colorectal cancer cell states to identify co-targeting opportunities and determinants of drug response.
3140 Background: Colorectal cancer (CRC) progression relies on multiple mechanistically distinct proliferative and surviva...
Apatinib combined with adebrelimab and GEMOX regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: A multicenter, open-label, single-arm, phase II trial.
e16202 Background: Immune checkpoint inhibitor combined with chemotherapy have shown improved prognosis compared with chem...
Operationalizing bispecific antibody therapy in community oncology: Capturing insights on clinician preparedness for using off-the-shelf immunotherapy in lymphoma and multiple myeloma.
e23221 Background: The emergence of bispecific antibodies as off-the-shelf immunotherapy for diffuse large B-cell lymphoma...
Indirect treatment comparison of cabozantinib vs sunitinib in the treatment of pancreatic neuroendocrine tumors.
e16327 Background: Pancreatic neuroendocrine tumors vary widely in grade, functionality, growth rate and aggressiveness. P...
First-in-human study of DM005, an anti-EGFR/c-MET bispecific antibody-drug conjugate, in patients with advanced solid tumors.
8530 Background: DM005 is a bispecific ADC (BsADC) conjugated to BLD1102, a linker/payload system composed of a linker and...
Characterization of genomic alterations between local breast cancers and cutaneous metastases.
1038 Background: Cutaneous metastases (CM) are a distinct manifestation of advanced breast cancer (BC), yet their genomic...
Scrambler therapy for painful chemotherapy-induced peripheral neuropathy: Extending the evidence base.
e24147 Background: Chemotherapy-induced peripheral neuropathy (CIPN) burdens patients. Six months after treatment, the inc...
Development and multicenter validation of a machine learning framework for predicting severe myelosuppression in nasopharyngeal carcinoma: Evidence from large-scale real-world data and prospective clinical trials.
6023 Background: Severe treatment-related myelosuppression (Tr-MS) in nasopharyngeal carcinoma (NPC) necessitates dose red...
Urinary creatine riboside for risk stratification of clinically significant prostate cancer.
e17149 Background: Distinguishing clinically significant prostate cancer from indolent disease remains a major challenge i...
National analysis of cancer care for refugees in Moldova during the war in Ukraine (2022–2025).
1602 Background: Following Russia's invasion of Ukraine in February 2022, Moldova, a non-EU country of 2.3 million, had on...
Prognostic stratification of early-stage NSCLC patients using preoperative circulating tumor DNA (ctDNA).
8031 Background: Curative-intent surgery for early-stage non-small-cell lung cancer (NSCLC) is followed by relapse in appr...
Dual-microbial signature as a predictor of postoperative colorectal cancer recurrence.
3611 Background: Current surveillance strategies for postoperative recurrence in colorectal cancer predominantly depend on...