Journal of Clinical Oncology
Articles in this Issue
Beyond convolution: Vision transformer–based modeling for histopathological classification of colorectal carcinoma.
e15671 Background: Colorectal carcinoma (CRC) is a major contributor to global cancer morbidity and mortality, with histop...
Once unthinkable: Population-level changes in five-year survival for metastatic non–small cell lung cancer in the immunotherapy era.
e20696 Background: Five-year survival in metastatic non–small cell lung cancer (NSCLC) was historically rare. The introduc...
Who receives CAR-T therapy? A national examination of racial and ethnic differences in hospitalized adults.
e18576 Background: CAR-T therapy has improved outcomes in hematologic malignancies but remains resource-intensive and larg...
Cancer risk and screening-preventable malignancies in transgender populations: A systematic review and meta-analysis.
e22522 Background: Transgender people experience health vulnerabilities shaped by structural barriers to care and differen...
Clinical utility of MRI in breast cancer diagnosed over age 70.
e12689 Background: Previous observational studies evaluating the role of MRI in the management of breast cancer patients h...
Interpretable machine learning to identify health system levers for survival outcomes of patients with breast cancer.
1594 Background: Breast cancer is the most commonly diagnosed cancer and a leading cause of cancer death among women world...
Neuroprotective potential of BOLD-100 when utilized in combination with FOLFOX for the treatment of advanced gastrointestinal cancers.
e15029 Background: BOLD-100 is a ruthenium-based anticancer agent in Phase 2 development for gastrointestinal (GI) cancers...
Safety and efficacy of puxitatug samrotecan (Puxi-Sam, AZD8205) in patients with biliary tract cancer (BTC): A first-in-human phase 1/2a study (BLUESTAR).
4106 Background: B7-H4 is a transmembrane glycoprotein that negatively regulates T-cell function and is highly expressed i...
Home-based palliative care delivery by a freelancing palliative care specialist to terminally ill cancer patients in Kolkata, India: An audit of the service model.
e24045 Background: Home-based palliative care (HBPC) can provide continuity of care, symptom-management and end-of-life-ca...
Can a simple pre-mobilization complete blood count predict stem cell yield? Low-cost predictors of CD34⁺ mobilization in multiple myeloma.
e19513 Background: Autologous hematopoietic stem cell transplantation (ASCT) remains a critical component of consolidation...
Temporal trends in oncology clinical trial complexity and duration: A retrospective analysis of 5,261 industry-sponsored trials.
11018 Background: Clinical trial complexity has been cited as a contributor to rising drug development costs and increasin...
Adherence to lower endoscopic surveillance in high-risk colorectal cancer populations: A meta-analysis of U.S. studies.
e22536 Background: High-risk individuals, including those with a history of colorectal cancer (CRC), advanced adenomas, or...
Genomic characterization and clinical associations of rare co-mutations in <i>RAS</i> and <i>RAF</i> genes in colorectal cancer.
e15581 Background: In colorectal cancer (CRC), mutations in RAS family genes and BRAF are typically mutually exclusive. Ho...
Feasibility and implementation of remote geriatric assessment–guided supportive care (GAIN-S) in public oncology settings.
1582 Background: The ASCO Global Guideline recommends routine geriatric assessment (GA) for adults aged ≥65 years with can...
Dual BRAF/MEK inhibition in <i>BRAF</i> <sup>V600E</sup> –mutated biliary tract cancer with exploratory histology-dependent response: A systematic review and meta-analysis.
4108 Background: The BRAF V600E mutation defines an actionable subset of rare cancers. Metastatic BTC carries a poor progn...
Determinants of pathologic complete response in early-stage triple-negative breast cancer at a single institution.
e12664 Background: Triple-negative breast cancer (TNBC) has been widely reported as having worse outcomes among Black wome...
Real-world efficacy and safety of darolutamide-based triplet therapy in Chinese patients with metastatic hormone-sensitive prostate cancer (mHSPC): A multicenter analysis from Zhejiang province (YHCG-006 study).
e17090 Background: The ARASENS trial established that androgen deprivation therapy (ADT) combined with Darolutamide and Do...
Stromal remodeling and neoantigen clonality as used to evaluate benefit from SIRT–nivolumab in HCC.
e16285 Background: The combination of selective internal radiation therapy (SIRT) and nivolumab has shown encouraging clin...
AI-driven RNA-based homologous recombination deficiency algorithm to predict first-line platinum response in metastatic pancreatic cancer.
4210 Background: Developing predictive diagnostics for metastatic pancreatic cancer remains an unmet clinical need. Here,...
Standardized mean differences of primary outcomes found in randomized controlled trials of wellness interventions among medical trainees: A systematic review and meta-analysis.
9011 Background: In the era of physician shortages, wellness interventions among medical trainees is an area of ongoing re...
Clinical outcomes for patients (pts) with synchronous versus metachronous metastatic urothelial cancer (mUC) treated with enfortumab vedotin and pembrolizumab (EV-P).
4587 Background: Synchronous versus metachronous metastases in mUC has prognostic significance, and EV-P has emerged as st...
Real-world post-APT trial adoption of de-escalated systemic therapy and outcomes in small HER2-positive breast cancer: An NCDB analysis.
539 Background: The APT trial shifted adjuvant management of small HER2-positive breast cancer towards paclitaxel-trastuzu...
RATIONALE-315: Post hoc analysis of event-free survival by surgically relevant subgroups treated with perioperative tislelizumab and neoadjuvant chemotherapy vs neoadjuvant chemotherapy.
8059 Background: RATIONALE-315 (NCT04379635) compared the efficacy and safety of perioperative tislelizumab (TIS) or place...
Allogeneic CD19-targeted CAR-T therapy (BRL-301) for relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL).
e14518 Background: Despite advances in treatment, outcomes for adults with relapsed or refractory B-cell acute lymphoblast...
A multi-omic analysis of EOCRC: Divergent methylation and gene expression signatures in young patients.
3582 Background: The incidence of early-onset colorectal cancer (EOCRC; diagnosis < 50 years) is rising at an alarming...