Journal of Clinical Oncology
Articles in this Issue
Recurrence modeling with electronic health records through natural language processing and machine learning techniques.
e18004 Background: Head and neck cancer patients with locally advanced disease requiring free flap reconstruction are at h...
Environmental co-benefits of WISDOM risk-based breast cancer screening: A multi-institutional pathway-based life cycle assessment.
e23224 Background: The WISDOM randomized clinical trial demonstrated that risk-based breast cancer screening incorporating...
The economic and clinical impact of lung cancer patient support programs (LC-PSP) using real-world (RW) clinical outcomes.
e23026 Background: Timely access to precision therapies is critical to improving lung cancer outcomes. Canada’s universal...
Global trends in incidence and mortality of liver cancer by etiology and sociodemographic index among adolescents and young adults, 1990–2023.
e22583 Background: Liver cancer in adolescents and young adults (AYA) is an emerging global challenge with evolving etiolo...
Safety and efficacy of ZN-A-1041, a highly blood-brain barrier (BBB)–permeable HER2 tyrosine kinase inhibitor (TKI), + trastuzumab deruxtecan (T-DXd) or pertuzumab-trastuzumab (PH) in HER2-positive metastatic breast cancer (HER2+ mBC): Phase Ic expansion results from the ZN-A-1041-101-US trial.
1055 Background: Brain metastases (BMs) are a common site of progression in HER2+ mBC due to limited BBB penetration of sy...
Glucagon-like peptide-1 receptor agonist use in lung cancer patients receiving immune checkpoint inhibitors: A real-world study.
8598 Background: Immune checkpoint inhibitors (ICI) have become a cornerstone of treatment for lung cancer. Glucagon-like...
K-ACCELERATE: A multi-center prospective trial to evaluate the utility of a ctDNA-based assay for accelerating multi-cancer diagnosis among high-risk symptomatic participants.
10555 Background: In low- and middle-income countries, most cancers are diagnosed after symptom onset, where non-specific...
Examining the relationship between social support and inflammatory markers among patients with gynecologic cancer.
5626 Background: Social support has been associated with improved health outcomes. Little research on the association betw...
A randomized, double-blind, two-arm, single-dose, parallel study to compare the pharmacokinetics, pharmacodynamics, safety, and immunogenicity of Bmab 1000 and originator denosumab in healthy male participants.
e15001 Background: Bmab 1000 has been approved as a biosimilar to originator denosumab (DENO). This study compared the pha...
Natural language processing–assisted chart review to assess documented cannabis use in electronic medical records (EMR) of adults undergoing cancer infusion therapy.
11125 Background: Patients’ consumption of cannabis for symptom management is well-documented, yet prevalence of cannabis...
An integrated population pharmacokinetic/pharmacodynamic (popPK/PD) model to select the linvoseltamab (LINVO) dosing regimen in patients with high-risk smoldering multiple myeloma (HR-SMM).
7525 Background: LINVO is a BCMA×CD3 bispecific antibody approved for triple-class exposed relapsed/refractory (RR) multip...
An NCDB analysis on the demographic, treatment, and survival of seromucinous carcinoma.
e17538 Background: Seromucinous carcinoma (SMC) is a rare subtype of ovarian cancer composed predominantly of serous and e...
Enhanced recovery after surgery (ERAS) pathways in gynecologic oncology: A systematic review and meta-regression of perioperative domains.
e17537 Background: Enhanced Recovery After Surgery (ERAS) pathways are multimodal perioperative care programs designed to...
Clinician readiness and ethical thresholds for agentic AI autonomy in oncology care: A multi-specialty survey.
e13699 Background: Artificial intelligence (AI) systems capable of autonomous reasoning areemerging in oncology. This stud...
Impact of cooking-related household air pollution (HAP) on never-smoker NSCLC risk in women: Systematic review and meta-analysis.
e20690 Background: Among pollutants, exposure to cooking-related household air pollution (HAP) is a significant environmen...
Organ-specific endocrine toxicities and serious outcomes associated with immune checkpoint inhibitors: A contemporary pharmacovigilance analysis (2020–2024).
e24197 Background: Endocrine immune-related adverse events (irAEs) are recognized complications of immune checkpoint inhib...
Real-world outcomes of 7+3 versus azacitidine/venetoclax in CML transformed to AML.
6579 Background: Although tyrosine kinase inhibitors (TKIs) have markedly improved outcomes in chronic myeloid leukemia (C...
Induction endocrine therapy in older and very old patients with breast cancer.
e12656 Background: Management of breast cancer (BC) in older adults is complicated by a high burden of comorbidity and sub...
Evaluation of the safety, efficacy and dosimetry of TRC003 in metastatic castration-resistant prostate cancer: A prospective, open-label, single-arm study.
5037 Background: TRC003 (also named as 225 Ac-PSMA-313) is a novel molecule of tar...
Applying learning science principles (LSP) in a workshop (WS) for hematology and oncology (HemOnc) trainees (HOT) about how to use artificial intelligence (AI) in medical education (MedEd) and clinical practice (CP).
9030 Background: AI use is ubiquitous among HOT and healthcare workers, but with variable base knowledge and comfort level...
Safety and efficacy of GT719, an off-the-shelf CAR-NKT therapy, in adults with relapsed or refractory CD19-positive B-cell malignancies.
7078 Background: GT719 is an off-the-shelf CAR-NKT therapy derived from umbilical cord blood hematopoietic stem cells and...
Green tea extract/catechin supplementation for secondary prevention of metachronous colorectal adenomas after polypectomy.
e15670 Background: Green tea extracts (GTE) have proposed protective effects in colorectal neoplasia, but randomized evide...
Phenotypic heterogeneity in primary tumors and brain metastases of small cell lung cancer: Insights into tumor microenvironment and metastatic behavior.
8114 Background: Small cell lung cancer (SCLC) is an aggressive malignancy with frequent brain metastases and pronounced p...
(RW) post-progression outcomes following first-line (1L) ribociclib (RIB) + aromatase inhibitor (AI) versus AI alone in African American and low socio-economic status (SES) patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2–) metastatic breast cancer (MBC) in US.
1073 Background: RIB + endocrine therapy (ET) demonstrated significant overall survival over ET alone in all three phase I...
Uncertainty-aware multimodal imaging for lung metastasis risk stratification in extremity soft-tissue sarcoma.
e23543 Background: In the field of soft-tissue sarcoma (STS), imaging-based risk prediction has been based on Radiomics an...