Journal of Clinical Oncology
Articles in this Issue
Efficacy and safety of antibody-drug conjugates in gastrointestinal malignancies: A systematic review and meta-analysis of phase I-III trials.
e15035 Background: Antibody-drug conjugates (ADCs) represent a promising targeted therapy class for GI malignancies, with...
SPECTRUM: Phase II study of tislelizumab plus pemetrexed in patients with relapsed or refractory (R/R) primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS)—The Korean Cancer Study Group LY22-07.
2009 Background: Primary DLBCL of the CNS is a rare extranodal lymphoma confined to the CNS. Despite standard high-dose me...
Rethinking risk: Disparities and genetic testing outcomes from a novel public-facing cancer prevention program.
e13607 Background: Identifying individuals at high risk for cancer is central to effective prevention and early detection....
Rezvilutamide (Rez) versus bicalutamide (Bic) plus androgen-deprivation therapy (ADT) in high-volume, metastatic, hormone-sensitive prostate cancer (mHSPC): 5-year outcomes of the phase 3 CHART trial.
5090 Background: In the CHART trial, Rez plus ADT significantly improved radiographic progression-free survival (rPFS) and...
Clinical characterization and survival of patients (pts) with <i>PIK3CA</i> -mutated metastatic colorectal cancer (mCRC): Individual patient data (IPD) meta-analysis of four randomized trials.
e15541 Background: We aimed to characterize pts with PIK3CA MUT mCRC and to estima...
Comparison of a highly sensitive, tumor-informed Illumina whole genome sequencing research assay and a tumor-informed bespoke whole exome sequencing assay for molecular residual disease detection in CheckMate-77T (NCT 04025879).
8591 Background: In CheckMate 77T (NCT 04025879), nivolumab showed clinically meaningful improvements in event free surviv...
Nodulomics: Histopathologic and genomic heterogeneity among multiple malignant pulmonary nodules sampled by robotic-assisted bronchoscopy.
8049 Background: Multiple pulmonary nodules (MPN) pose significant challenges for accurate staging of non-small cell lung...
Scalable knowledge distillation for pancreatic cancer diagnosis: Real-time ResNet-based stage stratification with global deployment feasibility.
e16412 Background: Pancreatic cancer remains one of the deadliest cancers, with a 5-year survival below 12%. Early-stage d...
MRI-derived tumor burden and growth rate as translational biomarkers: Head-to-head comparison with RECIST and ctDNA in tebentafusp-treated metastatic uveal melanoma.
e21584 Background: Tebentafusp improves survival in metastatic uveal melanoma (mUM), yet RECIST v1.1 responses are uncommo...
A matched-adjusted indirect comparison (MAIC) of nogapendekin alfa inbakicept-pmln plus bacillus Calmette–Guérin (NAI+BCG) and pembrolizumab in patients with BCG-unresponsive non–muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) ± papillary disease.
e16619 Background: Several FDA approved treatments offer bladder-sparing options for patients with BCG-unresponsive NMIBC...
A randomized controlled pilot study of aromatherapy to reduce anxiety and pain during bone marrow aspiration and biopsy.
12140 Background: Bone marrow aspiration and biopsy (BMAB) is associated with substantial anxiety and pain among patients...
Prognostic impact of cancer stem cell markers on survival outcomes in solid tumors: A systematic review and meta-analysis.
e15187 Background: Cancer stem cell (CSC) markers have been implicated in tumor aggressiveness and treatment resistance. P...
Autologous natural killer cell infusion as consolidation therapy after first-line chemoradiotherapy for limited-stage small-cell lung cancer: A randomized, controlled, open-label, single-center phase II clinical study.
8013 Background: Small-cell lung cancer (SCLC) grows rapidly, is aggressive, has a poor prognosis, and tends to recur afte...
BNT324-03: Phase 3, randomized, open-label trial of BNT324/DB-1311, a B7H3 ADC, versus docetaxel in patients with taxane-naïve metastatic castration-resistant prostate cancer (mCRPC).
TPS5137 Background: B7H3 is highly expressed in various human cancers, including mCRPC, and overexpression is associated w...
Impact of pre-existing autoimmune disease on clinical outcomes in patients treated with bispecific monoclonal antibodies for B-cell lymphomas.
e19008 Background: Bispecific antibodies (BsAbs), including glofitamab, epcoritamab, and mosunetuzumab, are FDA-approved f...
Efficacy and safety outcomes of biweekly compared with standard triweekly gemcitabine/nab-paclitaxel in advanced pancreatic cancer: A systematic review and meta-analysis.
e16405 Background: Pancreatic cancer remains one of the most lethal malignancies, with a rising incidence and persistently...
STRATOS-P clinical model for prognosis and selection of patients with metastatic hormone sensitive prostate cancer (mHSPC) for intermittent therapy.
5106 Background: Current trials use prostate-specific antigen (PSA) response of ≤0.2 ng/mL at 6-12 months as a prognostic...
The impact of high body-mass index on cancer mortality in the United States: An emerging public health challenge.
10626 Background: Obesity prevalence has increased markedly in the United States, yet the contribution of high body-mass i...
Rates of metachronous colorectal cancer or secondary Lynch syndrome–related cancers in patients with non-metastatic colorectal cancer.
3648 Background: Lynch syndrome (LS) increases metachronous colorectal cancer (CRC) risk up to 5-fold, while extended rese...
SWOG S2107: Randomized phase II trial of encorafenib and cetuximab with or without nivolumab for patients with previously treated MSS, <i> BRAF <sup>V600E</sup> </i> metastatic colorectal cancer (mCRC).
3504 Background: BRAF V600E mutation...
Enhanced financial assistance intervention for unmet essential needs: A prospective pilot study to improve timely cancer treatment completion.
11078 Background: Unmet essential needs, such as food, transportation, and housing insecurity, can create barriers to time...
PACT-chemo: Improving chemotherapy flow, safety, and value through physician–pharmacist EHR activation at SSMC, a tertiary hospital in the Middle East.
e23317 Background: Chemotherapy order activation is a major ambulatory infusion bottleneck and a key point to intercept hi...
BCG at home: A first-in-kind pilot trial of home-based intravesical Bacillus Calmette-Guérin delivery for high-risk non-muscle-invasive bladder cancer.
e13615 Background: Bacillus Calmette-Guérin (BCG) remains the standard intravesical therapy for high-risk non-muscle-invas...
Survival outcomes with modern first-line systemic therapy in advanced hepatocellular carcinoma: A systematic review and meta-analysis.
e16218 Background: First-line systemic therapy for advanced hepatocellular carcinoma (HCC) has evolved from tyrosine kinas...
Neurological adverse events related to immune checkpoint inhibitors in cancer treatment: A systematic review and meta-analysis of clinical trials.
e14569 Background: Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment with significant improvements i...