Journal of Clinical Oncology
Articles in this Issue
Development and evaluation of a novel digital pathology image analysis pipeline for prediction of clinical outcomes with the TROP2-directed antibody-drug conjugate (ADC) sacituzumab tirumotecan (sac-TMT) in triple-negative breast cancer (TNBC).
1026 Background: Digital pathology (DP), including artificial intelligence (AI)-based image analysis methods, enables IHC...
Spatially organized immune niches in high-grade primary prostate cancer.
5118 Background: Prostate cancer (PC) has historically been considered immunologically “cold” due to low immune infiltrati...
Disruption of the ATAD3A-VDAC1 complex to enhance anti-tumor immunity and response to immune checkpoint blockade in lung adenocarcinoma.
e20623 Background: Elucidating the role of mitochondrial function in anti-tumor immunity is crucial for improving the effi...
Tuning CAR-T cell response with <i>TNFAIP3</i> variants.
e14527 Background: The clinical success of Chimeric Antigen Receptor (CAR)-T cell therapy is frequently limited by two maj...
Impact of diabetes on respiratory infection risk and hospitalization following immune checkpoint inhibitor initiation in non–small cell lung cancer: A propensity-matched retrospective cohort analysis.
11187 Background: Immune checkpoint inhibitors (ICIs) are a cornerstone of treatment for non-small cell lung cancer (NSCLC...
Variations in ambient airborne carcinogen concentrations (particulate matter; PM <sub>2.5</sub> ) in urban neighborhoods in Rhode Island.
e22514 Background: Fine particulate matter smaller than 2.5 μm in diameter (PM 2.5...
A translational approach for in vitro monitoring of patient-derived tumor organoid responses to anti-cancer treatments.
e15610 Background: Patient-derived organoids are often considered the 3D in vitro...
Real-world inpatient outcomes in Hispanic patients with primary HCC/biliary tract cancer: A retrospective cohort study of admission MELD-Na and hospital mortality, ICU use, and length of stay (2019–2025).
e16303 Background: Hepatic reserve is a key determinant of outcomes in hospitalized hepatocellular carcinoma (HCC) and bil...
Relationship between GLP-1 receptor agonists on cancer recurrence and survival of patients with stage I-III colorectal cancer: A retrospective cohort study using the TriNetX database.
3636 Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, and obesity is...
CCL3 <sup>+</sup> neutrophil signature as a predictor of response to neoadjuvant toripalimab plus chemotherapy in hypopharyngeal squamous cell carcinoma: A phase II trial.
6116 Background: Hypopharyngeal squamous cell carcinoma (HPSCC) has a poor prognosis. Although neoadjuvant chemoimmunother...
The role of adjuvant chemotherapy in high-risk stage II colon cancer with microsatellite instability-high or DNA mismatch repair deficiencies: A multicenter pooled analysis (KCSG-CO24-03).
3622 Background: The benefit of adjuvant chemotherapy (CTx) for high-risk stage II MSI-H/dMMR colon cancer remains controv...
Real-world clinical utility of comprehensive genomic and transcriptomic profiling in metastatic breast cancer (mBC).
e13080 Background: Integrated DNA/RNA comprehensive genomic profiling (CGP) may expand therapeutic opportunities and suppo...
Association of thymic epithelial tumors (TETs) with Lynch syndrome (LS) per germline genetic testing and molecular tumor analysis.
10615 Background: LS is a hereditary cancer syndrome that increases risk for gastrointestinal, gynecologic, genitourinary,...
Overall survival and treatment-related outcomes with FOLFIRINOX compared with gemcitabine/nab-paclitaxel in metastatic pancreatic cancer.
e16436 Background: FOLFIRINOX and gemcitabine plus nab-paclitaxel are commonly used first-line regimens for metastatic pan...
Clinical decision impact of 18F-PSMA-1007 PET/CT for prostate cancer staging: Avoiding over- and under-treatment versus bone scintigraphy.
e15088 Background: For medical oncologists and multidisciplinary teams, staging is not descriptive - it determines treatme...
Expression of CXCR4 in gastric NENs.
e16312 Background: Gastric neuroendocrine neoplasms (gNENs) are a rare and heterogeneous group of tumors that include well...
Stage-specific survival trends in small cell lung cancer in the United States: A population-based analysis.
e20129 Background: Small cell lung cancer (SCLC) is an aggressive malignancy with historically poor survival outcomes. Whi...
Tumor shrinkage and depth of response with fruquintinib in patients with metastatic colorectal cancer: Results from FRESCO and FRESCO-2.
3555 Background: In metastatic colorectal cancer (mCRC), early tumor shrinkage (ETS) and depth of response (DpR) are predi...
Racial and geographic disparities in Hodgkin lymphoma mortality among adolescents and young adults in the United States, 1999-2023.
e13738 Background: Hodgkin lymphoma (HL) in adolescents and young adults (AYAs) is highly curable, and population-level mo...
Malnutrition as a hidden driver of inpatient mortality in gastrointestinal cancer: A national analysis of the U.S. National Inpatient Sample, 2016–2023.
e23235 Background: Inpatient mortality among patients with gastrointestinal (GI) malignancies remains high, yet risk strat...
Proactive response initiative for symptom management (PRISM): A multi-institutional symptom monitoring program for veterans receiving systemic cancer therapy.
11115 Background: Symptom assessment and management in cancer care are challenging. Within the Veterans Health Administrat...
Single-cell multi-omics and TCR sequencing to identify early tumor cavity homing and phenotypic evolution of CAR-T cells in glioblastoma.
2554 Background: Chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable efficacy in hematological malignanc...
From pixel to precision: A systematic review of CT radiomics in the diagnosis of the <i>EGFR</i> mutation in non–small cell lung carcinoma.
e20001 Background: Lung cancer is the leading cause of cancer mortality, with non-small cell lung cancer being more common...
Real-world challenges in the adoption of emerging therapies for extensive-stage small cell lung cancer in community settings.
8113 Background: Despite advances in the treatment of extensive-stage small cell lung cancer (ES-SCLC), outcomes remain po...
Effect of gut microbiota–derived testosterone on distant metastasis in non–small cell lung cancer.
8548 Background: Distant metastasis is the major cause of poor prognosis in non–small cell lung cancer (NSCLC). Emerging e...