Browse Articles

One-year epidemiological patterns of respiratory pathogens across age, gender, and seasons in Chengdu during the post-COVID era

Enhanced non-classical electrostriction in strained tetragonal ceria

Predictive markers of rapid disease progression and chemotherapy resistance in triple-negative breast cancer patients following postoperative adjuvant therapy

Guadua angustifolia biochar/TiO2 composite and biochar as bio-based materials with environmental and agricultural application

Interface-engineered non-volatile visible-blind photodetector for in-sensor computing

Prognosis of patients with breast cancer who underwent breast-conserving surgery using a 3D-printed surgical guide after neoadjuvant chemotherapy

Comparative diagnostic performance of recombinant Tams1 protein based dot-ELISA in detecting tropical theileriosis in naturally infected cattle

Highly stable perovskite solar cells with 0.30 voltage deficit enabled by a multi-functional asynchronous cross-linking

Hyperspectral inversion of heavy metal content in farmland soil under conservation tillage of black soils

A novel and efficient digital image steganography technique using least significant bit substitution

Carbene-catalyzed chirality-controlled site-selective acylation of saccharides

Enhanced photovoltaic panel diagnostics through AI integration with experimental DC to DC Buck Boost converter implementation

Clinical predictive model of new-onset atrial fibrillation in patients with acute myocardial infarction after percutaneous coronary intervention

Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging

A systematic review and meta-analysis on light therapy for sleep disorders in shift workers

Post-myocardial infarction ventricular septal defects: incidence and treatment trends during and after the COVID-19 pandemic

Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function

AbstractDissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary metabolite profiling, as widely applied for blood biomarker studies. Here we report a genome-wide association study meta-analysed for 3 European cohorts comprising 8,011 individuals, covering both people with type 1 diabetes and general population settings. We identify 54 associations (p < 9.3 × 10−10) for 19 of 54 studied metabolite concentrations. Out of these, 33 were not reported previously for relevant urinary or blood metabolite traits. Subsequent two-sample Mendelian randomization analysis suggests that estimated glomerular filtration rate causally affects 13 urinary metabolite concentrations whereas urinary ethanolamine, an initial precursor for phosphatidylcholine and phosphatidylethanolamine, was associated with higher eGFR lending support for a potential protective role. Our study provides a catalogue of genetic associations for 53 metabolites, enabling further investigation on how urinary metabolites are linked to human health.

Global stability boundary analysis and verification of aviation pressure servo-controlled actuator system

Identification of deposits from modern and ancient large tsunamis by means of environmental DNA

AbstractWe examined the potential of environmental DNA (eDNA) for identifying tsunami deposits in the geological record using lake-bottom sediments in the Tohoku region, Japan. The presence of eDNA from marine organisms in a lacustrine event deposit provides very strong evidence that the deposit was formed by an influx of water from the ocean. The diverse DNA assemblage in the deposit formed by the 2011 Tohoku-oki tsunami included DNA of marine origin indicating that eDNA has potential as an identifying proxy for tsunami deposits. Subsequently, we examined the applicability of eDNA for recognizing paleo-tsunami events using the deposits formed by the 869 CE Jogan tsunami and a prehistoric event (2400–2900 cal year BP). The taxa detected in the tsunami deposits were markedly different from those of the background sediments. Many taxa that were represented in the Jogan tsunami deposit were also detected in the layer immediately above the tsunami deposit. This layer was indistinguishable from the overlying peat by visual observation, but the eDNA results suggest that it is likely to be a muddy tsunami deposit. The results of this study indicate that eDNA has the potential to elucidate the origin of event deposits that have been difficult to identify.

Automatic feature selection and weighting in molecular systems using Differentiable Information Imbalance