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Microstructure and mechanical properties of highly porous Hastelloy-X nickel superalloy produced by a space holder approach
Abstract Highly porous nickel-based superalloys appear as attractive candidates to be applied e.g. as seals in gas turbine engines instead of honeycomb structures. Among various methods of producing open-porous materials, a space holder approach provides number of benefits regarding economic and ecological aspects of production. In this work, the pioneering results of microstructure and mechanical properties analyses of highly porous Hastelloy-X nickel superalloy produced by the space holder approach, are presented. The materials were fabricated by using spherical fine Hastelloy-X powders and carbamide particles as batch materials. A multi-step powder metallurgy and thermomechanical processing was applied to produce open porous samples having a total volumetric porosity of 50, 60 and 70%. The produced materials were subjected to non-destructive (X-ray computed tomography) and metallographic inspections. Mechanical properties of the porous Hastelloy-X samples were examined in static room temperature compression tests, to discuss the effect of obtained porosity on compressive response.
Supervised multi-frame dual-channel denoising enables long-term single-molecule FRET under extremely low photon budget
Miles to Go and Nowhere to Sleep
Identification of the CaCRT gene family and function of CaCRT1 under low-temperature stress in pepper (Capsicum annuum L.)
Cuproptosis related lncRNA signature as a prognostic and therapeutic biomarker in osteosarcoma immunity
Presence of liver metastasis correlated with high tumor abundance and indicated adverse prognostic feature in EGFR mutation non-small-cell lung cancer patients
Improved silicon solar cells by tuning angular response to solar trajectory
Congenital Spinal Meningocele
Deficiency in NPC2 results in disruption of mitochondria-late endosome/lysosomes contact sites and endo-lysosomal lipid dyshomeostasis
Arctiin alleviates the progression of osteoarthritis by regulating the cholesterol metabolic pathway
Elevated GGT to HDL ratio as a marker for the risk of NAFLD and liver fibrosis
A new-to-nature photosynthesis system enhances utilization of one-carbon substrates in Escherichia coli
Westermark’s Sign and Palla’s Sign in Pulmonary Embolism
Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis
A recent large-scale intraspecific IR expansion and evolutionary dynamics of the plastome of Peucedanum japonicum
The predictive value of combined insulin resistance and β-cell secretion in Yemeni school-aged children for type 2 diabetes mellitus
Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation
AbstractGlucose deprivation, a hallmark of the tumor microenvironment, compels tumor cells to seek alternative energy sources for survival and growth. Here, we show that glucose deprivation upregulates the expression of mitochondrial-cytochrome c oxidase II (MT-CO2), a subunit essential for the respiratory chain complex IV, in facilitating glutaminolysis and sustaining tumor cell survival. Mechanistically, glucose deprivation activates Ras signaling to enhance MT-CO2 transcription and inhibits IGF2BP3, an RNA-binding protein, to stabilize MT-CO2 mRNA. Elevated MT-CO2 increases flavin adenosine dinucleotide (FAD) levels in activating lysine-specific demethylase 1 (LSD1) to epigenetically upregulate JUN transcription, consequently promoting glutaminase-1 (GLS1) and glutaminolysis for tumor cell survival. Furthermore, MT-CO2 is indispensable for oncogenic Ras-induced glutaminolysis and tumor growth, and elevated expression of MT-CO2 is associated with poor prognosis in lung cancer patients. Together, these findings reveal a role for MT-CO2 in adapting to metabolic stress and highlight MT-CO2 as a putative therapeutic target for Ras-driven cancers.