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Neonatal intensive care admissions and exposure to satellite-derived air pollutants in the United States, 2018
Self-assembled materials with an ordered hydrophilic bilayer for high performance inverted Perovskite solar cells
When Blurry Vision Clouds the Bigger Picture
Association between the Chinese Visceral Adiposity Index and the risk of Benign Prostatic Hyperplasia: a national prospective cohort study
Analysis of the mediating role of life style in the relationship between health literacy and self-rated health employing structural equation modeling
The anticancer activity of fucoidan coated selenium nanoparticles and curcumin nanoparticles against colorectal cancer lines
Reversible multivalent carrier redox exceeding intercalation capacity boundary
Chronic Myeloid Leukemia with Hyperleukocytosis
Association between transcription factors expression and growth patterns of nonfunctioning pituitary adenomas
Renal impairment as a risk factor for chemotherapy induced neutropenia in the treatment of trifluridine/thymidine phosphorylase inhibitor plus bevacizumab
Analysis of precancerous lesion-related microRNAs for early diagnosis of cervical cancer in the Thai population
Dissipative Landau-Zener tunneling in the crossover regime from weak to strong environment coupling
AbstractLandau-Zener tunneling, which describes the transition in a two-level system during a sweep through an anti-crossing, is a model applicable to a wide range of physical phenomena. Realistic quantum systems are affected by dissipation due to coupling to their environments. An important aspect of understanding such open quantum systems is the relative energy scales of the system itself and the system-environment coupling, which distinguishes the weak- and strong-coupling regimes. Using a tunable superconducting flux qubit, we observe the crossover from weak to strong coupling to the environment in Landau-Zener tunneling. Our results confirm previous theoretical studies of dissipative Landau-Zener tunneling in the weak and strong coupling limits. We devise a spin bath model that effectively captures the crossover regime. This work is relevant for understanding the role of dissipation in quantum annealing, where the system is expected to go through a cascade of Landau-Zener transitions before reaching the target state.
NEJM at ESMO — Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma
Chaos-enhanced manganese electrolysis: nodule suppression and improved efficiency using controllable chaotic electrical signals
ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma
Identification model of mine water inrush source based on XGBoost and SHAP
Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy
Abstract Eicosanoids are key players in inflammatory diseases and cancer. Targeting their production by inhibiting Group IVA cytosolic phospholipase A 2 (cPLA 2 α) offers a promising approach for cancer therapy. In this study, we synthesize a second generation of thiazolyl ketone inhibitors of cPLA 2 α starting with compound GK470 (AVX235) and test their in vitro and cellular activities. We identify a more potent and selective lead molecule, GK420 (AVX420), which we test in parallel with AVX235 and a structurally unrelated compound, AVX002 for inhibition of cell viability across a panel of cancer cell lines. From this, we show that activity of polycomb group repressive complex 2 is a key molecular determinant of sensitivity to cPLA 2 α inhibition, while resistance depends on antioxidant response pathways. Consistent with these results, we show that elevated intracellular reactive oxygen species and activating transcription factor 4 target gene expression precede cell death in AVX420-sensitive T-cell acute lymphoblastic leukemia cells. Our findings imply cPLA 2 α may support cancer by mitigating oxidative stress and inhibiting tumor suppressor expression and suggest that AVX420 has potential for treating acute leukemias and other cancers that are susceptible to oxidative cell death.