Browse Articles
Discover research articles across all indexed journals
A tale of two planets: Disparate evolutionary models for Mars inferred from radiogenic isotope compositions of Martian meteorites
The radiogenic isotopic compositions of basaltic Martian meteorites (shergottites) and clinopyroxene/olivine cumulate meteorites (nakhlite/chassignites) are used to define the global evolution of Mars. However, the two main groups of meteorites demonstrate that their sources underwent divergent styles of magmatic evolution. The shergottites portray a planet that differentiated ~4.52 billion years ago via solidification of a magma ocean, producing incompatible element-depleted and -enriched reservoirs that remained isolated until melt production. In contrast, the reservoir from which the nakhlite/chassignites derive may have formed earlier, produced melts that fractionated Sm/Nd and Hf/W differently, was compositionally less variable, and experienced a significantly more complex history following primordial differentiation than the shergottite sources. The disparate histories recorded by these two groups of meteorites elucidate important questions that could be addressed by acquiring additional samples. Obtaining samples that shared the isotopic systematics of the shergottites would provide confidence that extrapolating the primordial differentiation history of Mars from shergottite radiogenic isotope systematics is reasonable. Returned samples from Mars will also constrain the physical locations of the meteorite source regions, providing insights into the general structure of the Martian mantle. In addition, they will help constrain the phases present in the martian mantle during melting and the conditions under which they are stable. Finally, identifying an evolved lithology that satisfies the geochemical and isotopic constraints placed on the incompatible element-enriched endmember observed in the shergottites would define the nature of magmatic evolution on Mars and whether it is more akin to processes on the Earth or the Moon.
Metagenome-guided culturomics for the targeted enrichment of gut microbes
Abstract The gut microbiome significantly impacts human health, yet cultivation challenges hinder its exploration. Here, we combine deep whole-metagenome sequencing with culturomics to selectively enrich for taxa and functional capabilities of interest. Using a modified commercial base medium, 50 growth modifications were evaluated, spanning antibiotics, physico-chemical conditions, and bioactive compounds. Whole-metagenome sequencing identified medium additives, like caffeine, that enhance taxa often associated with healthier subjects (e.g., Lachnospiraceae, Oscillospiraceae, Ruminococcaceae). We also explore the impact of modifications on the composition of cultured communities and establish a link between medium preference and microbial phylogeny. Leveraging these insights, we demonstrate that combinations of media modifications can further enhance the targeted enrichment of taxa and metabolic functions, such as Collinsella aerofaciens, or strains harboring biochemical pathways involved in dopamine metabolism. This streamlined, scalable approach unlocks the potential for selective enrichment, advancing microbiome research by understanding the impact of different cultivation parameters on gut microbes.
Impact of irrelevant speech and non-speech sounds on serial recall of verbal and spatial items in children and adults
Abstract Short-term memory for sequences of verbal items such as written words is reliably impaired by task-irrelevant background sounds, a phenomenon known as the “Irrelevant Sound Effect” (ISE). Different theoretical accounts have been proposed to explain the mechanisms underlying the ISE. Some of these assume specific interference between obligatory sound processing and phonological or serial order representations generated during task performance, whereas other posit that background sounds involuntarily divert attention away from the focal task. To explore the roles of phonological processing, serial order retention, and attention control, we analyzed the effects of environmental non-speech sounds and unfamiliar speech on serial recall of verbal items (pictures representing German nouns) and spatial items (dot locations) in children (n = 137) and adults (n = 98). In the verbal task, both age groups were equally affected by background sounds, with speech impairing recall more than environmental sounds. In the spatial task, no ISE was found in adults and fourth graders, but third graders exhibited significant performance impairment from both sounds. There was no habituation to the sound effects across the experimental trials. The findings indicate that both specific interference and attention capture may contribute to the ISE, with the impact of attention capture potentially decreasing with age.
What we can learn about Mars from the magnetism of returned samples
The Red Planet is a magnetic planet. The Martian crust contains strong magnetization from a core dynamo that likely was active during the Noachian period when the surface may have been habitable. The evolution of the dynamo may have played a central role in the evolution of the early atmosphere and the planet’s transition to the current cold and dry state. However, the nature and history of the dynamo and crustal magnetization are poorly understood given the lack of well-preserved, oriented, ancient samples with geologic context available for laboratory study. Here, we describe how magnetic measurements of returned samples could transform our understanding of six key unknowns about Mars’ planetary evolution and habitability. Such measurements could i) determine the history of the Martian dynamo field’s intensity; ii) determine the history of the Martian dynamo field’s direction; iii) test the hypothesis that Mars experienced plate tectonics or true polar wander; iv) constrain the thermal and aqueous alteration history of the samples; v) identify sources of Martian crustal magnetization and vi) characterize sedimentary and magmatic processes on Mars. We discuss how these goals can be achieved using future laboratory analyses of samples acquired by the Perseverance rover.
Vialess heterogeneous skin patch for multimodal monitoring and stimulation
Abstract System-level wearable electronics require to be flexible to ensure conformal contact with the skin, but they also need to integrate rigid and bulky functional components to achieve system-level functionality. As one of integration methods, folding integration offers simplified processing and enhanced functionality through rigid-soft region separation, but so far, it has mainly been applied to modality of electrical sensing and stimulation. This paper introduces a vialess heterogeneous skin patch with multi modalities that separates the soft region and strain-robust region through folded structure. Our system includes electrical and optical modalities for hemodynamic and cardiovascular monitoring, and a force-electrically driven micropump for drug delivery. Each modality is demonstrated through on-demand drug delivery, flexible waveguide-based PPG monitoring, and ECG and body movement monitoring. Wireless data transmission and real-time measurement validate the feedback operation for multi-modalities. This engineered closed-loop platform offers the possibility for broad applications, including cardiovascular monitoring and chronic disease management.
Research on coordination mechanism between agricultural green and land ecosystem in Yellow River Basin
Constraining the history of water and climate on Mars through light element stable isotope analysis of volatiles in returned martian samples
Much has been learned about Mars through data returned from space missions and analyses of martian meteorites. There are, however, many questions still outstanding which cannot currently be answered—including the issue of whether there is, or was, life on Mars. The return of a cache of samples—including of the atmosphere—from separate locations in Jezero Crater and with differing petrogeneses will provide the international community with the opportunity to explore part of the evolutionary history of Mars in great detail. Specifically, measurements of the isotopic compositions of the light elements H, C, N, O, Cl, and S can be used to follow how volatile species cycle through the different martian volatile reservoirs (atmosphere, lithosphere, cryosphere, and hydrosphere). Measurement of isotopic fractionation enables inference of the environmental conditions (e.g., temperature, water/rock ratio) under which fractionation occurred. Knowing the contextual relationship of the materials to their geological settings, coupled with precise compositional measurements will enable a more thorough understanding of martian volatile history and allow a picture to be constructed of water and climate on Mars as represented at Jezero Crater.
Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT
Abstract Conjugation plays a major role in dissemination of antimicrobial resistance genes. Following transfer of IncF-like plasmids, recipients become refractory to a second wave of conjugation with the same plasmid via entry (TraS) and surface (TraT) exclusion mechanisms. Here, we show that TraT from the pKpQIL and F plasmids (TraT pKpQIL and TraT F ) exhibits plasmid surface exclusion specificity. The cryo-EM structures of TraT pKpQIL and TraT F reveal that they oligomerise into decameric champagne bottle cork-like structures, which are anchored to the outer membrane via a diacylglycerol and palmitic acid modified α-helical barrel domain. Unexpectedly, we identify chromosomal TraT homologues from multiple Gram-negative phyla which form numerous divergent lineages in a phylogenetic tree of TraT sequences. Plasmid-associated TraT sequences are found in multiple distinct lineages, including two separate clades incorporating TraT from Enterobacteriaceae IncF/F-like and Legionellaceae F-like plasmids. These findings suggest that different plasmid backbones have acquired and co-opted TraT on independent occasions.
The modulating effect of circulating carbohydrate antigen 125 on ST2 and long-term recurrent morbidity burden
Evolution of the iodine cycle and the late stabilization of the Earth’s ozone layer
The origin of complex life and the evolution of terrestrial ecosystems are fundamental aspects of the natural history on Earth. Here, we present evidence for a protracted stabilization of the Earth’s ozone layer. The destruction of atmospheric ozone today is inherently linked to the cycling of marine and atmospheric iodine. Supported by multiple independent lines of geological evidence and examined through an iodine mass balance model, we find that elevated marine iodide content prevailed through most of Earth’s history. Since the rise of oxygen ~2.4 billion years ago, high marine iodide concentrations would have led to significant inorganic iodine emissions to the atmosphere, facilitating catalytic ozone destruction and resulting in atmospheric ozone instability with periodic or persistently lower ozone levels. At a global scale, unstable and low ozone levels likely persisted for about two billion years until the early Phanerozoic, roughly 0.5 billion years ago. The delayed stabilization of the Earth’s ozone layer holds significant implications for the tempo and direction of the evolution of life, in particular life on land.
Early life microbial succession in the gut follows common patterns in humans across the globe
Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study
Abstract Skin cancer is one of the most common types of cancer worldwide, with exposure to UVB radiation being a significant risk factor for its development. To prevent skin cancer, continuous research efforts have focused on finding suitable photoprotective ingredients from natural sources that are also environmentally friendly. This study aimed to develop oil-in-water photoprotective nanoemulsions containing marine macroalgae extract. A Box–Behnken experimental design was used to identify the most promising formulation composition, resulting in optimal physical properties. These properties, including droplet size, polydispersity index (PDI), and zeta potential, were evaluated using dynamic light scattering (DLS). To assess the photoprotection capacity of the formulations, electrical impedance spectroscopy (EIS) was employed to evaluate alterations in the electrical characteristics of excised pig skin membranes placed in Franz cells equipped with a 4-electrode set-up. The final composition of the nanoemulsion was caprylic/capric triglycerides 4%, Macrogolglycerol ricinoleate 30%, and algae extract 1%. The nanoemulsions had an average droplet size of 128.5 ± 8.6 nm, a PDI of 0.25 ± 0.06, and a zeta potential of 45.14 ± 0.02 mV. Compared to the control group, the photoprotective capacity of the oil-in-water nanoemulsions was statistically significant. Specifically, only a 15% reduction in the skin membrane electrical resistance following UVB exposure was observed when the formulation containing algae extract was used, whereas a 50% reduction was observed for the vehicle. In conclusion, this work demonstrates that the developed nanoemulsions based on natural ingredients show promising protective capacity against UVB exposure of the skin.
All-angle unidirectional flat-band acoustic metasurfaces
An intrusion detection model based on Convolutional Kolmogorov-Arnold Networks
Sampling Mars: Geologic context and preliminary characterization of samples collected by the NASA Mars 2020 Perseverance Rover Mission
The NASA Mars 2020 Perseverance Rover Mission has collected samples of rock, regolith, and atmosphere within the Noachian-aged Jezero Crater, once the site of a delta-lake system with a high potential for habitability and biosignature preservation. Between sols 109 and 1,088 of the mission, 27 sample tubes have been sealed, including witness tubes. Each sealed sample tube has been collected along with detailed documentation provided by the Perseverance instrument payload, preserving geological and environmental context. Samples representative of the stratigraphy within each of four campaigns have been collected: samples from the Crater Floor Campaign represent a suite of potentially petrogenetically related igneous rocks displaying variable degrees of aqueous alteration; samples from the Fan Front record fluvial to deltaic sediments formed by the transport and deposition of materials from the Jezero watershed; regolith samples from the Fan Front preserve material possibly representative of global dust as well as diverse, locally derived clasts; Upper Fan samples record the latest stages of aqueous activity within Jezero; and samples from the Margin Campaign preserve lacustrine, littoral, or possibly igneous processes that may have occurred early in the history of the crater. Along with anticipated samples from the older rocks within the rim of Jezero Crater, Perseverance promises to deliver a suite of samples preserving a diversity of formation environments and ages. Upon return to Earth and analysis in terrestrial laboratories, these samples would address longstanding questions pertaining to the geologic evolution of Mars, its habitability, and the potential for life outside the Earth.
White light-emitting electrochemical cells based on metal-free TADF emitters
Abstract The attainment of white emission from a light-emitting electrochemical cell (LEC) is important, since it enables illumination and facile color conversion from devices that can be cost-efficient and sustainable. However, a drawback with current white LECs is that they either employ non-sustainable metals as an emitter constituent or are intrinsically efficiency limited by that the emitter only converts singlet excitons to photons. Organic compounds that emit by thermally activated delayed fluorescence (TADF) can address these issues since they can harvest all excitons for light emission while being metal free. Here, we report on the first white LEC based on solely metal-free TADF emitters, as accomplished through careful tuning of the energy-transfer processes and the electrochemically formed doping structure in the single-layer active material. The designed TADF-LEC emits angle-invariant white light (color rendering index = 88) with an external quantum efficiency of 2.1 % at a luminance of 350 cd/m 2 .
Influencing factors and quantitative prediction of gas content of deep marine shale in Luzhou block
Transforming literature screening: The emerging role of large language models in systematic reviews
Systematic reviews (SR) synthesize evidence-based medical literature, but they involve labor-intensive manual article screening. Large language models (LLMs) can select relevant literature, but their quality and efficacy are still being determined compared to humans. We evaluated the overlap between title- and abstract-based selected articles of 18 different LLMs and human-selected articles for three SR. In the three SRs, 185/4,662, 122/1,741, and 45/66 articles have been selected and considered for full-text screening by two independent reviewers. Due to technical variations and the inability of the LLMs to classify all records, the LLM’s considered sample sizes were smaller. However, on average, the 18 LLMs classified 4,294 (min 4,130; max 4,329), 1,539 (min 1,449; max 1,574), and 27 (min 22; max 37) of the titles and abstracts correctly as either included or excluded for the three SRs, respectively. Additional analysis revealed that the definitions of the inclusion criteria and conceptual designs significantly influenced the LLM performances. In conclusion, LLMs can reduce one reviewer´s workload between 33% and 93% during title and abstract screening. However, the exact formulation of the inclusion and exclusion criteria should be refined beforehand for ideal support of the LLMs.